Platelet degranulation Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. (Gene Ontology, GO_0002576)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-114608
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Genes

79 proteins participating in the Platelet degranulation pathway from the Reactome Pathways dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTN1 actinin, alpha 1
ACTN2 actinin, alpha 2
ACTN4 actinin, alpha 4
ALB albumin
ALDOA aldolase A, fructose-bisphosphate
APOA1 apolipoprotein A-I
APP amyloid beta (A4) precursor protein
BRPF3 bromodomain and PHD finger containing, 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALU calumenin
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CD36 CD36 molecule (thrombospondin receptor)
CD63 CD63 molecule
CD9 CD9 molecule
CFD complement factor D (adipsin)
CFL1 cofilin 1 (non-muscle)
CLU clusterin
EGF epidermal growth factor
F13A1 coagulation factor XIII, A1 polypeptide
F5 coagulation factor V (proaccelerin, labile factor)
F8 coagulation factor VIII, procoagulant component
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FLNA filamin A, alpha
FN1 fibronectin 1
GAS6 growth arrest-specific 6
HABP4 hyaluronan binding protein 4
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HRG histidine-rich glycoprotein
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KNG1 kininogen 1
LAMP2 lysosomal-associated membrane protein 2
LEFTY2 left-right determination factor 2
MMRN1 multimerin 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PF4 platelet factor 4
PFN1 profilin 1
PLEK pleckstrin
PLG plasminogen
POTEKP POTE ankyrin domain family, member K, pseudogene
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIA peptidylprolyl isomerase A (cyclophilin A)
PROS1 protein S (alpha)
PSAP prosaposin
SCG3 secretogranin III
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SOD1 superoxide dismutase 1, soluble
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
TF transferrin
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLN1 talin 1
TMSB4X thymosin beta 4, X-linked
TTN titin
TUBA4A tubulin, alpha 4a
VCL vinculin
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
VEGFC vascular endothelial growth factor C
VWF von Willebrand factor
WDR1 WD repeat domain 1