Personality Disorders Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D010554
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Genes

268 genes/proteins associated with the disease Personality Disorders from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.88009
DRD2 dopamine receptor D2 2.42534
FOS FBJ murine osteosarcoma viral oncogene homolog 2.37572
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.34276
DRD1 dopamine receptor D1 2.31721
BDNF brain-derived neurotrophic factor 2.26963
PRL prolactin 2.25305
MAPK1 mitogen-activated protein kinase 1 2.21403
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.20886
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.1973
MAPK3 mitogen-activated protein kinase 3 2.18999
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 2.18399
EGR1 early growth response 1 2.16402
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.15812
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.15781
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 2.13227
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.10929
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.1023
CAT catalase 2.0973
POMC proopiomelanocortin 2.04476
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.01814
TNF tumor necrosis factor 2.01677
CRH corticotropin releasing hormone 1.99921
BCL2 B-cell CLL/lymphoma 2 1.99719
TAC1 tachykinin, precursor 1 1.98439
PENK proenkephalin 1.95117
DRD3 dopamine receptor D3 1.93643
CREB1 cAMP responsive element binding protein 1 1.93261
NPY neuropeptide Y 1.91814
JUNB jun B proto-oncogene 1.89327
PDYN prodynorphin 1.88995
JUN jun proto-oncogene 1.88917
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.88523
GFAP glial fibrillary acidic protein 1.86392
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.85573
TH tyrosine hydroxylase 1.85309
BAX BCL2-associated X protein 1.84853
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 1.81866
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.80849
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.80038
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.79846
MAPK8 mitogen-activated protein kinase 8 1.77724
OPRM1 opioid receptor, mu 1 1.75875
GAL galanin/GMAP prepropeptide 1.74721
ARC activity-regulated cytoskeleton-associated protein 1.74119
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.73495
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.73455
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.71193
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.68527
TRH thyrotropin-releasing hormone 1.68253
SOD1 superoxide dismutase 1, soluble 1.66684
MAOA monoamine oxidase A 1.66576
CDK5 cyclin-dependent kinase 5 1.66167
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.65797
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.61713
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.6146
MAOB monoamine oxidase B 1.61248
ADRA1B adrenoceptor alpha 1B 1.59943
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.59497
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.59288
COMT catechol-O-methyltransferase 1.59218
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.59125
HOMER1 homer scaffolding protein 1 1.59125
ADORA2A adenosine A2a receptor 1.58065
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.58065
CREM cAMP responsive element modulator 1.58065
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.57735
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.56971
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.56263
VEGFA vascular endothelial growth factor A 1.55698
GNAS GNAS complex locus 1.5479
GSK3B glycogen synthase kinase 3 beta 1.53061
DUSP1 dual specificity phosphatase 1 1.53036
FNDC4 fibronectin type III domain containing 4 1.52515
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.52061
PRKCD protein kinase C, delta 1.51986
GRM1 glutamate receptor, metabotropic 1 1.51632
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.51506
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.51205
PRKCB protein kinase C, beta 1.50928
S100B S100 calcium binding protein B 1.50323
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.50043
C10ORF10 chromosome 10 open reading frame 10 1.49967
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.49558
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.49558
GRM5 glutamate receptor, metabotropic 5 1.49174
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.4871
CALCA calcitonin-related polypeptide alpha 1.48684
PRKCA protein kinase C, alpha 1.48684
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.46986
IL6 interleukin 6 1.46595
NUPR1 nuclear protein, transcriptional regulator, 1 1.45857
NOS2 nitric oxide synthase 2, inducible 1.45803
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.44517
OXT oxytocin/neurophysin I prepropeptide 1.44246
IL1B interleukin 1, beta 1.43892
BCL2L1 BCL2-like 1 1.4275
RGS4 regulator of G-protein signaling 4 1.42723
EGR2 early growth response 2 1.42562
ADORA1 adenosine A1 receptor 1.42562
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.42347
DDIT3 DNA-damage-inducible transcript 3 1.41559
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.41451
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 1.41146
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 1.40486
ADRA1A adrenoceptor alpha 1A 1.40232
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.40204
FOSL2 FOS-like antigen 2 1.39924
INHBE inhibin, beta E 1.3903
SOD2 superoxide dismutase 2, mitochondrial 1.38469
DRD4 dopamine receptor D4 1.38298
MAPK14 mitogen-activated protein kinase 14 1.37874
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.37733
DLG4 discs, large homolog 4 (Drosophila) 1.36961
CCND3 cyclin D3 1.36905
HSPA8 heat shock 70kDa protein 8 1.36848
INS insulin 1.35991
TGFB2 transforming growth factor, beta 2 1.35906
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.35041
CNR1 cannabinoid receptor 1 (brain) 1.34955
IFNG interferon, gamma 1.34811
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.33612
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 1.33375
GSTP1 glutathione S-transferase pi 1 1.32696
EGR3 early growth response 3 1.32192
TAGLN transgelin 1.32103
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.31506
LHB luteinizing hormone beta polypeptide 1.3103
AVP arginine vasopressin 1.30911
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.30238
CES2 carboxylesterase 2 1.2975
JUND jun D proto-oncogene 1.2975
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 1.29657
ACHE acetylcholinesterase (Yt blood group) 1.2941
ELK1 ELK1, member of ETS oncogene family 1.29194
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.2898
PRKCG protein kinase C, gamma 1.28672
NTS neurotensin 1.28549
CALM2 calmodulin 2 (phosphorylase kinase, delta) 1.2772
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.27626
ADAM1A ADAM metallopeptidase domain 1A (pseudogene) 1.2596
PER2 period circadian clock 2 1.25868
FAS Fas cell surface death receptor 1.25525
PVALB parvalbumin 1.25494
DCAF8 DDB1 and CUL4 associated factor 8 1.254
GAP43 growth associated protein 43 1.25028
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.24718
GJA1 gap junction protein, alpha 1, 43kDa 1.24087
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.23042
SGK1 serum/glucocorticoid regulated kinase 1 1.22884
GRIK5 glutamate receptor, ionotropic, kainate 5 1.22632
CCL2 chemokine (C-C motif) ligand 2 1.22469
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.22306
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.22242
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.21855
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.21823
CXCL8 chemokine (C-X-C motif) ligand 8 1.21823
CCND1 cyclin D1 1.21534
CSNK2A1 casein kinase 2, alpha 1 polypeptide 1.21468
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 1.2137
GRIK2 glutamate receptor, ionotropic, kainate 2 1.2137
HRH1 histamine receptor H1 1.21304
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.21271
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.20526
GRK6 G protein-coupled receptor kinase 6 1.2013
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 1.1977
SREBF2 sterol regulatory element binding transcription factor 2 1.19639
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.19542
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.18424
NCAN neurocan 1.18359
DCAF6 DDB1 and CUL4 associated factor 6 1.173
PLXND1 plexin D1 1.16335
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.16269
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 1.16269
LDLR low density lipoprotein receptor 1.15899
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.15899
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.15458
PRKCE protein kinase C, epsilon 1.15458
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.15357
S100A8 S100 calcium binding protein A8 1.15256
ADCY5 adenylate cyclase 5 1.15223
HPCAL1 hippocalcin-like 1 1.14747
MAP2 microtubule-associated protein 2 1.14678
PRKCZ protein kinase C, zeta 1.14678
NGF nerve growth factor (beta polypeptide) 1.14473
ADRB1 adrenoceptor beta 1 1.14404
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 1.1437
NGFR nerve growth factor receptor 1.1437
DUSP6 dual specificity phosphatase 6 1.13793
OPRL1 opiate receptor-like 1 1.13793
CCK cholecystokinin 1.13793
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.13758
FABP1 fatty acid binding protein 1, liver 1.13586
PLCG1 phospholipase C, gamma 1 1.13484
GH1 growth hormone 1 1.13177
GDNF glial cell derived neurotrophic factor 1.12906
IGF1 insulin-like growth factor 1 (somatomedin C) 1.12838
HPN hepsin 1.12426
NPPA natriuretic peptide A 1.12082
HIGD1A HIG1 hypoxia inducible domain family, member 1A 1.11945
INHA inhibin, alpha 1.11945
FGF2 fibroblast growth factor 2 (basic) 1.11911
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.11571
EYA2 EYA transcriptional coactivator and phosphatase 2 1.11081
SYT11 synaptotagmin XI 1.11081
PARP1 poly (ADP-ribose) polymerase 1 1.11046
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.10872
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.10353
EGFR epidermal growth factor receptor 1.10282
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.10246
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.10211
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.10175
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 1.09822
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 1.09822
STX1B syntaxin 1B 1.09611
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.09541
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.09506
CDK4 cyclin-dependent kinase 4 1.09226
MMP9 matrix metallopeptidase 9 1.09154
TSHB thyroid stimulating hormone, beta 1.08833
CRHR1 corticotropin releasing hormone receptor 1 1.08619
CAMK2D calcium/calmodulin-dependent protein kinase II delta 1.08231
CCKBR cholecystokinin B receptor 1.08231
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 1.07093
TGFB1 transforming growth factor, beta 1 1.06917
THRA thyroid hormone receptor, alpha 1.06844
HPCAL4 hippocalcin like 4 1.06808
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.06698
CAMK2B calcium/calmodulin-dependent protein kinase II beta 1.06698
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1.06625
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.06333
TP53 tumor protein p53 1.06333
HMOX1 heme oxygenase 1 1.06225
EFNA3 ephrin-A3 1.06152
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 1.05972
GCLM glutamate-cysteine ligase, modifier subunit 1.05936
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 1.05535
GIPC1 GIPC PDZ domain containing family, member 1 1.05498
NCL nucleolin 1.05237
NCAM1 neural cell adhesion molecule 1 1.05237
RELN reelin 1.05237
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.05052
REN renin 1.05015
ALPP alkaline phosphatase, placental 1.04904
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 1.04904
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.04868
PDE10A phosphodiesterase 10A 1.04868
NOS1 nitric oxide synthase 1 (neuronal) 1.04831
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.04721
EIF5A eukaryotic translation initiation factor 5A 1.04538
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.04389
SCG2 secretogranin II 1.04389
SC5D sterol-C5-desaturase 1.04201
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.03939
S100A9 S100 calcium binding protein A9 1.03827
NPTX2 neuronal pentraxin II 1.03678
RGS9 regulator of G-protein signaling 9 1.03678
IL2 interleukin 2 1.03493
EDN1 endothelin 1 1.02821
OPRD1 opioid receptor, delta 1 1.02522
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.02188
FSHB follicle stimulating hormone, beta polypeptide 1.02114
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 1.01966
PER1 period circadian clock 1 1.01852
PKM pyruvate kinase, muscle 1.01625
ATRX alpha thalassemia/mental retardation syndrome X-linked 1.01549
STXBP1 syntaxin binding protein 1 1.01437
CTSK cathepsin K 1.01249