Parkinson Disease, Secondary Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D010302
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Genes

315 genes/proteins associated with the disease Parkinson Disease, Secondary from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
SHH sonic hedgehog 2.88009
RGS2 regulator of G-protein signaling 2 2.88009
GDNF glial cell derived neurotrophic factor 2.88009
ATP13A2 ATPase type 13A2 2.88009
PARK2 parkin RBR E3 ubiquitin protein ligase 2.88009
DRD2 dopamine receptor D2 2.51736
PRL prolactin 2.5
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.34297
DRD1 dopamine receptor D1 2.33926
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.26235
TH tyrosine hydroxylase 2.21567
FOS FBJ murine osteosarcoma viral oncogene homolog 2.1934
BCL2 B-cell CLL/lymphoma 2 2.17019
BDNF brain-derived neurotrophic factor 2.13425
BAX BCL2-associated X protein 2.11955
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.10941
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.10653
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.10553
TNF tumor necrosis factor 2.09533
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.08989
CAT catalase 2.05595
EGR1 early growth response 1 1.99596
MAPK1 mitogen-activated protein kinase 1 1.97082
NOS2 nitric oxide synthase 2, inducible 1.96269
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.94658
MAPK3 mitogen-activated protein kinase 3 1.93891
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.93582
MAPK8 mitogen-activated protein kinase 8 1.9296
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.92833
IL6 interleukin 6 1.92359
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.89423
TP53 tumor protein p53 1.88671
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.87393
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.86532
DDIT3 DNA-damage-inducible transcript 3 1.85344
PENK proenkephalin 1.84341
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.83895
JUN jun proto-oncogene 1.83396
SOD1 superoxide dismutase 1, soluble 1.83361
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.82954
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.80378
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.76092
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.73089
CCND1 cyclin D1 1.71091
GSK3B glycogen synthase kinase 3 beta 1.70906
SOD2 superoxide dismutase 2, mitochondrial 1.70471
FAS Fas cell surface death receptor 1.69167
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.68485
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.6789
CDK5 cyclin-dependent kinase 5 1.67633
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.67072
HMOX1 heme oxygenase 1 1.66986
IFNG interferon, gamma 1.66598
DRD3 dopamine receptor D3 1.66231
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.65643
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.64933
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.64595
BCL2L1 BCL2-like 1 1.64551
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.64033
GSTP1 glutathione S-transferase pi 1 1.63339
ACHE acetylcholinesterase (Yt blood group) 1.62848
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.62669
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.61575
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.61201
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.60734
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.58912
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.57971
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.57924
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.57594
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.57571
GFAP glial fibrillary acidic protein 1.57546
ADORA2A adenosine A2a receptor 1.57162
COMT catechol-O-methyltransferase 1.55329
IL1B interleukin 1, beta 1.5501
CNR1 cannabinoid receptor 1 (brain) 1.53699
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.53603
NUPR1 nuclear protein, transcriptional regulator, 1 1.53481
CTSL cathepsin L 1.53332
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.52036
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.5138
ERN1 endoplasmic reticulum to nucleus signaling 1 1.50423
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.50398
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.50069
CCL2 chemokine (C-C motif) ligand 2 1.49381
CREB1 cAMP responsive element binding protein 1 1.49356
MAOB monoamine oxidase B 1.49356
INS insulin 1.49356
TGFB1 transforming growth factor, beta 1 1.48916
GSTM1 glutathione S-transferase mu 1 1.48505
DUSP1 dual specificity phosphatase 1 1.48505
CYCS cytochrome c, somatic 1.48376
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.48196
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.46986
GSR glutathione reductase 1.46909
MAPK9 mitogen-activated protein kinase 9 1.45194
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.44872
VEGFA vascular endothelial growth factor A 1.44763
MAOA monoamine oxidase A 1.44626
UBC ubiquitin C 1.437
IGF1 insulin-like growth factor 1 (somatomedin C) 1.43673
TAGLN transgelin 1.4351
XBP1 X-box binding protein 1 1.4313
BMP4 bone morphogenetic protein 4 1.42723
MAPK14 mitogen-activated protein kinase 14 1.42589
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.42293
AVP arginine vasopressin 1.42211
DRD4 dopamine receptor D4 1.41368
GPX1 glutathione peroxidase 1 1.4026
ICAM1 intercellular adhesion molecule 1 1.39869
ODC1 ornithine decarboxylase 1 1.39422
APP amyloid beta (A4) precursor protein 1.39254
PDYN prodynorphin 1.39058
GCLC glutamate-cysteine ligase, catalytic subunit 1.38807
GAP43 growth associated protein 43 1.38752
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.38724
ADRB1 adrenoceptor beta 1 1.38043
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.37902
NOS1 nitric oxide synthase 1 (neuronal) 1.37619
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.37561
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.37475
RELN reelin 1.37075
PARK7 parkinson protein 7 1.36677
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.36447
CRH corticotropin releasing hormone 1.36418
RRM2 ribonucleotide reductase M2 1.3619
PF4 platelet factor 4 1.35877
PARP1 poly (ADP-ribose) polymerase 1 1.35127
CXCL8 chemokine (C-X-C motif) ligand 8 1.34343
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.34227
HSPA8 heat shock 70kDa protein 8 1.33909
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.3388
ATF3 activating transcription factor 3 1.33434
CASP12 caspase 12 (gene/pseudogene) 1.32192
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.30421
NFE2L2 nuclear factor, erythroid 2-like 2 1.29966
PTK2B protein tyrosine kinase 2 beta 1.28765
LEP leptin 1.28549
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.28456
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.28364
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.28364
FASN fatty acid synthase 1.28333
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 1.28149
CALM1 calmodulin 1 (phosphorylase kinase, delta) 1.28119
IL2 interleukin 2 1.28027
F2 coagulation factor II (thrombin) 1.27782
GSTO1 glutathione S-transferase omega 1 1.27782
ANXA2 annexin A2 1.27193
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 1.27162
MAP2K6 mitogen-activated protein kinase kinase 6 1.27162
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.26825
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.267
NQO1 NAD(P)H dehydrogenase, quinone 1 1.26267
ACO2 aconitase 2, mitochondrial 1.26236
PPARG peroxisome proliferator-activated receptor gamma 1.26175
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 1.25557
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.25557
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.25494
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.25338
GCLM glutamate-cysteine ligase, modifier subunit 1.24781
IL10 interleukin 10 1.24465
PDE4B phosphodiesterase 4B, cAMP-specific 1.24181
FSHB follicle stimulating hormone, beta polypeptide 1.24181
NPY neuropeptide Y 1.23837
OPRM1 opioid receptor, mu 1 1.23616
NOS3 nitric oxide synthase 3 (endothelial cell) 1.23392
BAK1 BCL2-antagonist/killer 1 1.23392
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.23265
JUNB jun B proto-oncogene 1.23011
HRH1 histamine receptor H1 1.2279
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.22664
PDE1B phosphodiesterase 1B, calmodulin-dependent 1.22145
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.21951
ENO1 enolase 1, (alpha) 1.21695
HSPE1 heat shock 10kDa protein 1 1.21695
E2F1 E2F transcription factor 1 1.21501
EFNB1 ephrin-B1 1.21435
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.21141
VGF VGF nerve growth factor inducible 1.20913
MAPT microtubule-associated protein tau 1.20881
BCHE butyrylcholinesterase 1.20848
ATF4 activating transcription factor 4 1.20687
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.20493
GNAS GNAS complex locus 1.20361
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.20262
DDIT4 DNA-damage-inducible transcript 4 1.19477
MMP9 matrix metallopeptidase 9 1.19412
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.19379
STAT4 signal transducer and activator of transcription 4 1.19312
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.19279
IL1A interleukin 1, alpha 1.19179
PDK4 pyruvate dehydrogenase kinase, isozyme 4 1.19047
SQSTM1 sequestosome 1 1.18685
S100A9 S100 calcium binding protein A9 1.18554
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.18326
TAC1 tachykinin, precursor 1 1.1786
UBB ubiquitin B 1.17827
EFNB3 ephrin-B3 1.17827
PRKCD protein kinase C, delta 1.17728
ARC activity-regulated cytoskeleton-associated protein 1.17662
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.16967
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.16866
GSTA4 glutathione S-transferase alpha 4 1.16633
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.166
GADD45A growth arrest and DNA-damage-inducible, alpha 1.1617
S100A8 S100 calcium binding protein A8 1.16137
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.15458
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.15357
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.13862
RET ret proto-oncogene 1.13862
TPI1 triosephosphate isomerase 1 1.13279
CCND3 cyclin D3 1.12973
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.12906
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.12838
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 1.12771
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.12391
CD36 CD36 molecule (thrombospondin receptor) 1.11911
HSPA1B heat shock 70kDa protein 1B 1.11911
FADS2 fatty acid desaturase 2 1.11843
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.11741
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.11606
GDF15 growth differentiation factor 15 1.11571
BAD BCL2-associated agonist of cell death 1.11396
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.11255
PCNA proliferating cell nuclear antigen 1.11255
MFGE8 milk fat globule-EGF factor 8 protein 1.10803
POMC proopiomelanocortin 1.10493
VIM vimentin 1.10424
ALB albumin 1.10175
NAMPT nicotinamide phosphoribosyltransferase 1.09892
TPH2 tryptophan hydroxylase 2 1.09857
HRAS Harvey rat sarcoma viral oncogene homolog 1.09786
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 1.09646
MCL1 myeloid cell leukemia 1 1.09611
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.09471
CTSB cathepsin B 1.09436
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.09366
ENO3 enolase 3 (beta, muscle) 1.09262
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.08584
ADIPOQ adiponectin, C1Q and collagen domain containing 1.08513
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 1.08478
MAG myelin associated glycoprotein 1.08442
OXT oxytocin/neurophysin I prepropeptide 1.08301
NRG1 neuregulin 1 1.08301
CHGA chromogranin A 1.07911
GMFB glia maturation factor, beta 1.07911
FKBP5 FK506 binding protein 5 1.07804
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 1.07696
MPO myeloperoxidase 1.07553
MEF2C myocyte enhancer factor 2C 1.07447
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 1.0734
CTSD cathepsin D 1.07269
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.07093
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.07057
BIRC5 baculoviral IAP repeat containing 5 1.07057
LPL lipoprotein lipase 1.06987
FOLR1 folate receptor 1 (adult) 1.06734
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.06698
ADORA1 adenosine A1 receptor 1.06552
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.06515
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit 1.06261
LHB luteinizing hormone beta polypeptide 1.06261
PRNP prion protein 1.06044
CHAT choline O-acetyltransferase 1.06044
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 1.05721
PNOC prepronociceptin 1.05237
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 1.05237
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.052
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.05052
EFNA1 ephrin-A1 1.05015
EIF2A eukaryotic translation initiation factor 2A, 65kDa 1.05015
TUBB tubulin, beta class I 1.05015
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 1.04904
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.04831
GAL galanin/GMAP prepropeptide 1.04684
WEE1 WEE1 G2 checkpoint kinase 1.04684
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.04684
CALR calreticulin 1.04574
MAP2 microtubule-associated protein 2 1.04352
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.04352
MMP2 matrix metallopeptidase 2 1.04276
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.04126
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 1.04051
ADRB2 adrenoceptor beta 2, surface 1.03939
CCNB1 cyclin B1 1.03901
GSK3A glycogen synthase kinase 3 alpha 1.03715
CRIP1 cysteine-rich protein 1 (intestinal) 1.03678
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.03678
COL1A1 collagen, type I, alpha 1 1.03678
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.03604
SIRT1 sirtuin 1 1.03567
CCK cholecystokinin 1.03382
CALM2 calmodulin 2 (phosphorylase kinase, delta) 1.03197
EPO erythropoietin 1.03197
ACSL6 acyl-CoA synthetase long-chain family member 6 1.03197
CDK2 cyclin-dependent kinase 2 1.03046
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.03046
LDLR low density lipoprotein receptor 1.03046
CYBB cytochrome b-245, beta polypeptide 1.02485
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.02485
TTL tubulin tyrosine ligase 1.02336
ANXA5 annexin A5 1.02262
PCDH7 protocadherin 7 1.02262
SRGN serglycin 1.02225
GSTA3 glutathione S-transferase alpha 3 1.02188
NR1D1 nuclear receptor subfamily 1, group D, member 1 1.02114
INHBE inhibin, beta E 1.01814
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 1.01814
NBN nibrin 1.01776
PRDX1 peroxiredoxin 1 1.01587
MAP2K1 mitogen-activated protein kinase kinase 1 1.01512
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) 1.01512
TXN thioredoxin 1.01399
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.01399
COX5A cytochrome c oxidase subunit Va 1.01324
S100B S100 calcium binding protein B 1.01212