Panic Disorder Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress. (Human Disease Ontology, DOID_594)
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Genes

78 genes associated with the Panic Disorder phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADORA2A adenosine A2a receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
ANO2 anoctamin 2, calcium activated chloride channel
APOE apolipoprotein E
AR androgen receptor
AVP arginine vasopressin
AVPR1A arginine vasopressin receptor 1A
AVPR1B arginine vasopressin receptor 1B
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
CALCOCO1 calcium binding and coiled-coil domain 1
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CCK cholecystokinin
CCKAR cholecystokinin A receptor
CCKBR cholecystokinin B receptor
CLU clusterin
COMT catechol-O-methyltransferase
CREB1 cAMP responsive element binding protein 1
CREM cAMP responsive element modulator
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DISC1 disrupted in schizophrenia 1
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD5 dopamine receptor D5
FAAH fatty acid amide hydrolase
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAL galanin/GMAP prepropeptide
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GLO1 glyoxalase I
GRP gastrin-releasing peptide
GRPR gastrin-releasing peptide receptor
HCRTR1 hypocretin (orexin) receptor 1
HCRTR2 hypocretin (orexin) receptor 2
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL10 interleukin 10
IL19 interleukin 19
LDHA lactate dehydrogenase A
LDHB lactate dehydrogenase B
LSAMP limbic system-associated membrane protein
MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
MAOA monoamine oxidase A
NPSR1 neuropeptide S receptor 1
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NPY5R neuropeptide Y receptor Y5
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PDE4B phosphodiesterase 4B, cAMP-specific
PER2 period circadian clock 2
PGR progesterone receptor
PKP1 plakophilin 1
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
RGS2 regulator of G-protein signaling 2
RGS7 regulator of G-protein signaling 7
SDK2 sidekick cell adhesion molecule 2
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
TACR1 tachykinin receptor 1
TMEM132D transmembrane protein 132D
TMEM132E transmembrane protein 132E
TMEM98 transmembrane protein 98
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TSPO translocator protein (18kDa)