Panic Disorder Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress. (Human Disease Ontology, DOID_594)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D016584
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Genes

281 genes/proteins associated with the disease Panic Disorder from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
PAND2 panic disorder 2 2.88009
CCKBR cholecystokinin B receptor 2.88009
INS insulin 2.88009
PAND3 panic disorder 3 2.88009
COMT catechol-O-methyltransferase 2.88009
ADORA2A adenosine A2a receptor 2.88009
PAND1 Panic disorder 1 2.88009
ADRA2A adrenoceptor alpha 2A 2.88009
PRL prolactin 2.31557
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.30958
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.27436
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.2062
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.19922
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.13069
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 2.12968
FOS FBJ murine osteosarcoma viral oncogene homolog 2.11447
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.10774
CRH corticotropin releasing hormone 2.05845
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.05483
BDNF brain-derived neurotrophic factor 2.05093
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.03728
TH tyrosine hydroxylase 1.98224
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.96147
CAT catalase 1.95888
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.95133
EGR1 early growth response 1 1.90259
MAPK1 mitogen-activated protein kinase 1 1.88753
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.88671
TNF tumor necrosis factor 1.87908
PENK proenkephalin 1.87376
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.87194
POMC proopiomelanocortin 1.85764
MAPK3 mitogen-activated protein kinase 3 1.84605
ARC activity-regulated cytoskeleton-associated protein 1.8306
CREB1 cAMP responsive element binding protein 1 1.79216
BCL2 B-cell CLL/lymphoma 2 1.78568
NPY neuropeptide Y 1.75738
GAL galanin/GMAP prepropeptide 1.74421
DRD2 dopamine receptor D2 1.74341
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.74119
BAX BCL2-associated X protein 1.72509
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.7014
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.66446
MAOA monoamine oxidase A 1.66231
IL6 interleukin 6 1.65797
NUPR1 nuclear protein, transcriptional regulator, 1 1.65489
IL10 interleukin 10 1.65445
SREBF1 sterol regulatory element binding transcription factor 1 1.6296
FAS Fas cell surface death receptor 1.61506
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.61342
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.61295
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.58795
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.57759
VEGFA vascular endothelial growth factor A 1.55182
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.54937
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.54888
TAGLN transgelin 1.54693
IL1A interleukin 1, alpha 1.52718
NOS2 nitric oxide synthase 2, inducible 1.52489
LEP leptin 1.52313
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.50928
LHB luteinizing hormone beta polypeptide 1.50827
SOD1 superoxide dismutase 1, soluble 1.50524
ADRB1 adrenoceptor beta 1 1.49711
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.48505
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 1.48454
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.48454
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.48248
EGFR epidermal growth factor receptor 1.48222
FSHB follicle stimulating hormone, beta polypeptide 1.4753
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.46986
HOMER1 homer scaffolding protein 1 1.46986
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 1.45115
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.44029
GSK3B glycogen synthase kinase 3 beta 1.43374
IL1B interleukin 1, beta 1.43266
TAC1 tachykinin, precursor 1 1.41748
INHA inhibin, alpha 1.41119
GFAP glial fibrillary acidic protein 1.4076
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.40732
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.39897
MAOB monoamine oxidase B 1.39535
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.3931
JUN jun proto-oncogene 1.3917
COL1A1 collagen, type I, alpha 1 1.38584
VCAM1 vascular cell adhesion molecule 1 1.38355
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.38015
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.38015
FABP1 fatty acid binding protein 1, liver 1.37817
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.37561
CYCS cytochrome c, somatic 1.36876
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.36791
OPRM1 opioid receptor, mu 1 1.3556
DRD1 dopamine receptor D1 1.35386
CNR1 cannabinoid receptor 1 (brain) 1.34606
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.34285
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.33791
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.33642
MSMO1 methylsterol monooxygenase 1 1.33523
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.32756
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.32547
DUSP1 dual specificity phosphatase 1 1.32458
EGR3 early growth response 3 1.31897
GNAS GNAS complex locus 1.31536
EGR2 early growth response 2 1.3036
LOX lysyl oxidase 1.30117
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.30117
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.29875
HDC histidine decarboxylase 1.29225
CST3 cystatin C 1.29194
REN renin 1.2895
MAP2 microtubule-associated protein 2 1.28241
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.2818
ADRB2 adrenoceptor beta 2, surface 1.28119
RGS2 regulator of G-protein signaling 2 1.28058
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 1.27936
MAPK8 mitogen-activated protein kinase 8 1.27875
PRKCE protein kinase C, epsilon 1.27845
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.27751
PKM pyruvate kinase, muscle 1.27626
PRKCB protein kinase C, beta 1.27626
LDLR low density lipoprotein receptor 1.27286
MAPK14 mitogen-activated protein kinase 14 1.27039
CALCA calcitonin-related polypeptide alpha 1.26825
HPCA hippocalcin 1.26638
NPPB natriuretic peptide B 1.25929
PLCD4 phospholipase C, delta 4 1.25899
EFNB3 ephrin-B3 1.25868
INHBE inhibin, beta E 1.25838
PHGDH phosphoglycerate dehydrogenase 1.25557
DCAF8 DDB1 and CUL4 associated factor 8 1.25152
MAP1A microtubule-associated protein 1A 1.25121
JUNB jun B proto-oncogene 1.24935
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.24781
GAP43 growth associated protein 43 1.24718
BCL2L1 BCL2-like 1 1.23993
DRD4 dopamine receptor D4 1.23962
XDH xanthine dehydrogenase 1.23424
NPPA natriuretic peptide A 1.23424
FGF2 fibroblast growth factor 2 (basic) 1.23265
GSTP1 glutathione S-transferase pi 1 1.22853
TFRC transferrin receptor 1.22821
OPRK1 opioid receptor, kappa 1 1.2279
C10ORF10 chromosome 10 open reading frame 10 1.22758
IGF1 insulin-like growth factor 1 (somatomedin C) 1.22727
FNDC4 fibronectin type III domain containing 4 1.22404
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.22339
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.22274
SPP1 secreted phosphoprotein 1 1.22209
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.21173
GRIK2 glutamate receptor, ionotropic, kainate 2 1.21108
CCND1 cyclin D1 1.21011
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.20816
WFS1 Wolfram syndrome 1 (wolframin) 1.2046
SOD2 superoxide dismutase 2, mitochondrial 1.20427
IGF1R insulin-like growth factor 1 receptor 1.19933
ADRBK1 adrenergic, beta, receptor kinase 1 1.199
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.19704
CTSD cathepsin D 1.19412
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.18751
CTSL cathepsin L 1.18521
TRH thyrotropin-releasing hormone 1.18293
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.18193
CCL3 chemokine (C-C motif) ligand 3 1.18093
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.18059
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.17827
AVP arginine vasopressin 1.17827
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 1.17563
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.17268
OPRD1 opioid receptor, delta 1 1.17268
TPH2 tryptophan hydroxylase 2 1.17202
S100A9 S100 calcium binding protein A9 1.17134
NOS1 nitric oxide synthase 1 (neuronal) 1.17
CHGA chromogranin A 1.165
PLXND1 plexin D1 1.16104
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.15797
RGS4 regulator of G-protein signaling 4 1.15627
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.1556
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.15526
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.15156
PTGDS prostaglandin D2 synthase 21kDa (brain) 1.15022
GFRA2 GDNF family receptor alpha 2 1.14954
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.14816
NFE2L1 nuclear factor, erythroid 2-like 1 1.14473
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.14234
NGF nerve growth factor (beta polypeptide) 1.14098
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.13518
ADRB3 adrenoceptor beta 3 1.13484
EIF4E eukaryotic translation initiation factor 4E 1.13484
DUSP8 dual specificity phosphatase 8 1.13041
CCL2 chemokine (C-C motif) ligand 2 1.13007
PLAT plasminogen activator, tissue 1.12737
BAD BCL2-associated agonist of cell death 1.12599
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 1.12599
TEX261 testis expressed 261 1.1253
HPN hepsin 1.12151
NPY1R neuropeptide Y receptor Y1 1.12117
SIGMAR1 sigma non-opioid intracellular receptor 1 1.12048
GJA1 gap junction protein, alpha 1, 43kDa 1.1198
DLAT dihydrolipoamide S-acetyltransferase 1.11707
CXCL2 chemokine (C-X-C motif) ligand 2 1.11466
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.11466
COL3A1 collagen, type III, alpha 1 1.11466
TP53 tumor protein p53 1.1136
GPX3 glutathione peroxidase 3 1.11255
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 1.11186
PDYN prodynorphin 1.11186
TIMP1 TIMP metallopeptidase inhibitor 1 1.11116
FABP3 fatty acid binding protein 3, muscle and heart 1.10631
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.10388
SYT4 synaptotagmin IV 1.10104
ADIPOQ adiponectin, C1Q and collagen domain containing 1.09963
SGK1 serum/glucocorticoid regulated kinase 1 1.09927
ODC1 ornithine decarboxylase 1 1.09822
NOS3 nitric oxide synthase 3 (endothelial cell) 1.09822
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 1.09576
TTR transthyretin 1.09541
OXTR oxytocin receptor 1.09541
ENO1 enolase 1, (alpha) 1.09366
RYR2 ryanodine receptor 2 (cardiac) 1.09154
ENC1 ectodermal-neural cortex 1 (with BTB domain) 1.09047
MMP9 matrix metallopeptidase 9 1.08655
LPL lipoprotein lipase 1.08584
CKB creatine kinase, brain 1.08513
NEFH neurofilament, heavy polypeptide 1.08513
CREM cAMP responsive element modulator 1.08266
ARRB2 arrestin, beta 2 1.07947
CXCL10 chemokine (C-X-C motif) ligand 10 1.07911
EPHA7 EPH receptor A7 1.07875
DRD3 dopamine receptor D3 1.07768
IFNG interferon, gamma 1.07447
HRH1 histamine receptor H1 1.07269
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.07199
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.07128
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.06844
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.06808
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.06552
HPCAL4 hippocalcin like 4 1.06515
SIVA1 SIVA1, apoptosis-inducing factor 1.06515
TUBB2A tubulin, beta 2A class IIa 1.06044
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.05972
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 1.059
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 1.05864
TSC22D1 TSC22 domain family, member 1 1.05828
MBP myelin basic protein 1.05828
OXT oxytocin/neurophysin I prepropeptide 1.05573
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 1.05349
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 1.05312
HCRT hypocretin (orexin) neuropeptide precursor 1.05274
H2AFY H2A histone family, member Y 1.05274
GRIA3 glutamate receptor, ionotropic, AMPA 3 1.04978
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.04868
THY1 Thy-1 cell surface antigen 1.04574
FN1 fibronectin 1 1.04538
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.04314
SREBF2 sterol regulatory element binding transcription factor 2 1.04276
RASD1 RAS, dexamethasone-induced 1 1.04239
SOCS1 suppressor of cytokine signaling 1 1.04239
SQLE squalene epoxidase 1.04163
ADORA1 adenosine A1 receptor 1.03939
PF4 platelet factor 4 1.03901
IGFBP3 insulin-like growth factor binding protein 3 1.03827
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 1.03382
IL2 interleukin 2 1.03046
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.02971
PRKCA protein kinase C, alpha 1.02522
EDN1 endothelin 1 1.02373
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.02299
SYP synaptophysin 1.02225
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.01966
MPO myeloperoxidase 1.01701
MAP2K7 mitogen-activated protein kinase kinase 7 1.01701
MAP2K1 mitogen-activated protein kinase kinase 1 1.01625
PER1 period circadian clock 1 1.01549
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.01399
STMN1 stathmin 1 1.01324
TIMP3 TIMP metallopeptidase inhibitor 3 1.01324
S100A8 S100 calcium binding protein A8 1.01324
DHRS3 dehydrogenase/reductase (SDR family) member 3 1.01249
HSPA8 heat shock 70kDa protein 8 1.01137
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 1.01099