Pancreatic Neoplasms Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

431 genes associated with the Pancreatic Neoplasms phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACE angiotensin I converting enzyme
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADCY5 adenylate cyclase 5
ADGRB3 adhesion G protein-coupled receptor B3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
AFP alpha-fetoprotein
AGER advanced glycosylation end product-specific receptor
AGMO alkylglycerol monooxygenase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMER1 APC membrane recruitment protein 1
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARID1A AT rich interactive domain 1A (SWI-like)
ARID1B AT rich interactive domain 1B (SWI1-like)
ARID2 AT rich interactive domain 2 (ARID, RFX-like)
ARNT aryl hydrocarbon receptor nuclear translocator
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATXN2 ataxin 2
AURKA aurora kinase A
AXIN2 axin 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCAR1 breast cancer anti-estrogen resistance 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCRP1 breakpoint cluster region pseudogene 1
BICD1 bicaudal D homolog 1 (Drosophila)
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CA11 carbonic anhydrase XI
CABLES2 Cdk5 and Abl enzyme substrate 2
CAPN10 calpain 10
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAT catalase
CCKBR cholecystokinin B receptor
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD86 CD86 molecule
CDA cytidine deaminase
CDC123 cell division cycle 123
CDC16 cell division cycle 16
CDC37 cell division cycle 37
CDC73 cell division cycle 73
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHCHD2P9 coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CLPTM1L CLPTM1-like
CLSTN1 calsyntenin 1
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
COL18A1 collagen, type XVIII, alpha 1
CSF1R colony stimulating factor 1 receptor
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTRB1 chymotrypsinogen B1
CTRB2 chymotrypsinogen B2
CUBN cubilin (intrinsic factor-cobalamin receptor)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCK deoxycytidine kinase
DCLK1 doublecortin-like kinase 1
DCTD dCMP deaminase
DGKB diacylglycerol kinase, beta 90kDa
DGKH diacylglycerol kinase, eta
DOCK7 dedicator of cytokinesis 7
DPP6 dipeptidyl-peptidase 6
DPYD dihydropyrimidine dehydrogenase
DUSP9 dual specificity phosphatase 9
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF3A eukaryotic translation initiation factor 3, subunit A
EPC1 enhancer of polycomb homolog 1 (Drosophila)
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
ETAA1 Ewing tumor-associated antigen 1
EVC Ellis van Creveld protein
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F5 coagulation factor V (proaccelerin, labile factor)
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
FAM3B family with sequence similarity 3, member B
FANCA Fanconi anemia, complementation group A
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FANCE Fanconi anemia, complementation group E
FANCF Fanconi anemia, complementation group F
FANCG Fanconi anemia, complementation group G
FANCL Fanconi anemia, complementation group L
FANCM Fanconi anemia, complementation group M
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FAT2 FAT atypical cadherin 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FKBP5 FK506 binding protein 5
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FTO fat mass and obesity associated
FUT2 fucosyltransferase 2 (secretor status included)
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FYN FYN proto-oncogene, Src family tyrosine kinase
GAA glucosidase, alpha; acid
GATA1 GATA binding protein 1 (globin transcription factor 1)
GC group-specific component (vitamin D binding protein)
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GGT1 gamma-glutamyltransferase 1
GLO1 glyoxalase I
GNAS GNAS complex locus
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
GPI glucose-6-phosphate isomerase
GPSM2 G-protein signaling modulator 2
GPX1 glutathione peroxidase 1
GSTA4 glutathione S-transferase alpha 4
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GUCY2F guanylate cyclase 2F, retinal
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HAVCR2 hepatitis A virus cellular receptor 2
HFE hemochromatosis
HHEX hematopoietically expressed homeobox
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HK2 hexokinase 2
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HNF4G hepatocyte nuclear factor 4, gamma
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA1B heat shock 70kDa protein 1B
HYKK hydroxylysine kinase
IDE insulin-degrading enzyme
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO2 indoleamine 2,3-dioxygenase 2
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGF2R insulin-like growth factor 2 receptor
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL10 interleukin 10
IL10RB interleukin 10 receptor, beta
IL17F interleukin 17F
IL18 interleukin 18
IL1B interleukin 1, beta
IL2 interleukin 2
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
INS insulin
IQGAP2 IQ motif containing GTPase activating protein 2
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAZF1 JAZF zinc finger 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNIP4 Kv channel interacting protein 4
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF14 Kruppel-like factor 14
KMT2C lysine (K)-specific methyltransferase 2C
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMA3 laminin, alpha 3
LIG3 ligase III, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LINC-PINT long intergenic non-protein coding RNA, p53 induced transcript
LINC00964 long intergenic non-protein coding RNA 964
LOC154449 uncharacterized LOC154449
LOC285593 uncharacterized LOC285593
LRP2 low density lipoprotein receptor-related protein 2
LSP1 lymphocyte-specific protein 1
LUM lumican
MADD MAP-kinase activating death domain
MAGEA6 melanoma antigen family A6
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK8 mitogen-activated protein kinase 8
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAT1A methionine adenosyltransferase I, alpha
MCPH1 microcephalin 1
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIPEPP2 mitochondrial intermediate peptidase pseudogene 2
MIR146A microRNA 146a
MIR196A2 microRNA 196a-2
MLH1 mutL homolog 1
MLH3 mutL homolog 3
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MPL MPL proto-oncogene, thrombopoietin receptor
MPO myeloperoxidase
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTHFSD methenyltetrahydrofolate synthetase domain containing
MTNR1B melatonin receptor 1B
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MUTYH mutY homolog
NALCN sodium leak channel, non selective
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NBN nibrin
NEK7 NIMA-related kinase 7
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NIN ninein (GSK3B interacting protein)
NOP14 NOP14 nucleolar protein
NOTCH1 notch 1
NOTCH2 notch 2
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR5A2 nuclear receptor subfamily 5, group A, member 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OGG1 8-oxoguanine DNA glycosylase
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OR13C4 olfactory receptor, family 13, subfamily C, member 4
PALB2 partner and localizer of BRCA2
PALLD palladin, cytoskeletal associated protein
PARP1 poly (ADP-ribose) polymerase 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDX1 pancreatic and duodenal homeobox 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLK2 polo-like kinase 2
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POLB polymerase (DNA directed), beta
PON1 paraoxonase 1
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRC1 protein regulator of cytokinesis 1
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCA protein kinase C, alpha
PRLHR prolactin releasing hormone receptor
PROX1 prospero homeobox 1
PRSS1 protease, serine, 1 (trypsin 1)
PRSS2 protease, serine, 2 (trypsin 2)
PSG2 pregnancy specific beta-1-glycoprotein 2
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRT protein tyrosine phosphatase, receptor type, T
PVT1 Pvt1 oncogene (non-protein coding)
PWAR1 Prader Willi/Angelman region RNA 1
RAB8A RAB8A, member RAS oncogene family
RAD21 RAD21 homolog (S. pombe)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD51D RAD51 paralog D
RAD54B RAD54 homolog B (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RB1 retinoblastoma 1
RBBP8 retinoblastoma binding protein 8
RBMX RNA binding motif protein, X-linked
RECQL RecQ helicase-like
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF43 ring finger protein 43
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RUNX1 runt-related transcription factor 1
RXRA retinoid X receptor, alpha
RYK receptor-like tyrosine kinase
SART1 squamous cell carcinoma antigen recognized by T cells
SBF2 SET binding factor 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SELE selectin E
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SF3B1 splicing factor 3b, subunit 1, 155kDa
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SHH sonic hedgehog
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIK3 SIK family kinase 3
SLC16A4 solute carrier family 16, member 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMC6 structural maintenance of chromosomes 6
SMO smoothened, frizzled class receptor
SNW1 SNW domain containing 1
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK7 serine peptidase inhibitor, Kazal type 7 (putative)
SSTR5 somatostatin receptor 5
STK11 serine/threonine kinase 11
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SUMO3 small ubiquitin-like modifier 3
SYT9 synaptotagmin IX
TACC3 transforming, acidic coiled-coil containing protein 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERT telomerase reverse transcriptase
TEX14 testis expressed 14
TFF1 trefoil factor 1
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THADA thyroid adenoma associated
TIAM1 T-cell lymphoma invasion and metastasis 1
TLE4 transducin-like enhancer of split 4
TLK2 tousled-like kinase 2
TNF tumor necrosis factor
TOPBP1 topoisomerase (DNA) II binding protein 1
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP53INP1 tumor protein p53 inducible nuclear protein 1
TP73 tumor protein p73
TREX1 three prime repair exonuclease 1
TSHR thyroid stimulating hormone receptor
TSPAN8 tetraspanin 8
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
U2AF2 U2 small nuclear RNA auxiliary factor 2
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
USP1 ubiquitin specific peptidase 1
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WFS1 Wolfram syndrome 1 (wolframin)
WT1 Wilms tumor 1
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YPEL2 yippee-like 2 (Drosophila)
YTHDC2 YTH domain containing 2
ZBED2 zinc finger, BED-type containing 2
ZBED3 zinc finger, BED-type containing 3
ZC3H7A zinc finger CCCH-type containing 7A
ZFAND6 zinc finger, AN1-type domain 6
ZIM2 zinc finger, imprinted 2
ZNF678 zinc finger protein 678
ZNRF3 zinc and ring finger 3