Pain Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. (Human Phenotype Ontology, HP_0012531)
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Genes

146 genes associated with the Pain phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABLIM3 actin binding LIM protein family, member 3
ADRA1A adrenoceptor alpha 1A
ADRA2A adrenoceptor alpha 2A
ADRA2C adrenoceptor alpha 2C
ADRB2 adrenoceptor beta 2, surface
ARRB2 arrestin, beta 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BDNF brain-derived neurotrophic factor
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCL2 chemokine (C-C motif) ligand 2
CCNJL cyclin J-like
CDA cytidine deaminase
CES2 carboxylesterase 2
CHRM1 cholinergic receptor, muscarinic 1
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CRH corticotropin releasing hormone
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDAH1 dimethylarginine dimethylaminohydrolase 1
DLD dihydrolipoamide dehydrogenase
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
EDN1 endothelin 1
FAAH fatty acid amide hydrolase
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GCH1 GTP cyclohydrolase 1
GLRA1 glycine receptor, alpha 1
GLT1D1 glycosyltransferase 1 domain containing 1
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GZMM granzyme M (lymphocyte met-ase 1)
HBB hemoglobin, beta
HBG2 hemoglobin, gamma G
HBS1L HBS1-like translational GTPase
HINT1 histidine triad nucleotide binding protein 1
HMOX1 heme oxygenase 1
HRH1 histamine receptor H1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGF2-AS IGF2 antisense RNA
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL13 interleukin 13
IL16 interleukin 16
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL6 interleukin 6
IL6R interleukin 6 receptor
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
LAMA4 laminin, alpha 4
LTA lymphotoxin alpha
MAOA monoamine oxidase A
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MECP2 methyl CpG binding protein 2
MEFV Mediterranean fever
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MVK mevalonate kinase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYPN myopalladin
NCALD neurocalcin delta
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRM1 opioid receptor, mu 1
OR5F1 olfactory receptor, family 5, subfamily F, member 1
OXT oxytocin/neurophysin I prepropeptide
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
POMC proopiomelanocortin
PON1 paraoxonase 1
PRIMPOL primase and polymerase (DNA-directed)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHEB Ras homolog enriched in brain
SCN9A sodium channel, voltage gated, type IX alpha subunit
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TAGAP T-cell activation RhoGTPase activating protein
TBK1 TANK-binding kinase 1
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TYMP thymidine phosphorylase
TYMS thymidylate synthetase
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZNF767P zinc finger family member 767, pseudogene