PNU-0293363-6573 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the PNU-0293363-6573 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTB actin, beta
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
APLP2 amyloid beta (A4) precursor-like protein 2
APP amyloid beta (A4) precursor protein
ARF1 ADP-ribosylation factor 1
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C14ORF1 chromosome 14 open reading frame 1
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CAPN7 calpain 7
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CDC6 cell division cycle 6
CDK16 cyclin-dependent kinase 16
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDYL chromodomain protein, Y-like
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLDN3 claudin 3
CLDND1 claudin domain containing 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DVL3 dishevelled segment polarity protein 3
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FAM179B family with sequence similarity 179, member B
FKBP1A FK506 binding protein 1A, 12kDa
FLII flightless I homolog (Drosophila)
FUS FUS RNA binding protein
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GDI2 GDP dissociation inhibitor 2
GLE1 GLE1 RNA export mediator
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HMG20B high mobility group 20B
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HPCAL1 hippocalcin-like 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0125 KIAA0125
KIAA1033 KIAA1033
LAMP1 lysosomal-associated membrane protein 1
LPAR2 lysophosphatidic acid receptor 2
MARK2 MAP/microtubule affinity-regulating kinase 2
MCM4 minichromosome maintenance complex component 4
MED6 mediator complex subunit 6
MPDU1 mannose-P-dolichol utilization defect 1
MSH6 mutS homolog 6
MTMR2 myotubularin related protein 2
MUC1 mucin 1, cell surface associated
MXD4 MAX dimerization protein 4
NFYC nuclear transcription factor Y, gamma
NNT nicotinamide nucleotide transhydrogenase
NUCB1 nucleobindin 1
PDAP1 PDGFA associated protein 1
PGD phosphogluconate dehydrogenase
PGRMC1 progesterone receptor membrane component 1
PHLDB1 pleckstrin homology-like domain, family B, member 1
PICALM phosphatidylinositol binding clathrin assembly protein
POGK pogo transposable element with KRAB domain
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPIF peptidylprolyl isomerase F
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF4B pre-mRNA processing factor 4B
PRUNE prune exopolyphosphatase
PTBP1 polypyrimidine tract binding protein 1
RAB5C RAB5C, member RAS oncogene family
RANBP9 RAN binding protein 9
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFC3 replication factor C (activator 1) 3, 38kDa
RHOBTB3 Rho-related BTB domain containing 3
RRM1 ribonucleotide reductase M1
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEC23A Sec23 homolog A (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SGPP1 sphingosine-1-phosphate phosphatase 1
SIGMAR1 sigma non-opioid intracellular receptor 1
SNX3 sorting nexin 3
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SQLE squalene epoxidase
SRPK2 SRSF protein kinase 2
STIP1 stress-induced phosphoprotein 1
TAGLN2 transgelin 2
TANK TRAF family member-associated NFKB activator
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast)
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM183A transmembrane protein 183A
TMEM230 transmembrane protein 230
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRRAP transformation/transcription domain-associated protein
TSPAN3 tetraspanin 3
VAMP3 vesicle-associated membrane protein 3
WDR1 WD repeat domain 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YIPF5 Yip1 domain family, member 5
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZFYVE21 zinc finger, FYVE domain containing 21
ZNF654 zinc finger protein 654
ZNF665 zinc finger protein 665

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
APH1A APH1A gamma secretase subunit
APOLD1 apolipoprotein L domain containing 1
ARL4A ADP-ribosylation factor-like 4A
ARPIN actin-related protein 2/3 complex inhibitor
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAX BCL2-associated X protein
BCORL1 BCL6 corepressor-like 1
BMS1 BMS1 ribosome biogenesis factor
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CCDC69 coiled-coil domain containing 69
CDC20 cell division cycle 20
CFAP44 cilia and flagella associated protein 44
CHMP6 charged multivesicular body protein 6
CHMP7 charged multivesicular body protein 7
CORO7 coronin 7
DEPDC1 DEP domain containing 1
DET1 de-etiolated homolog 1 (Arabidopsis)
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EMID1 EMI domain containing 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAAH fatty acid amide hydrolase
FBXO46 F-box protein 46
FGL1 fibrinogen-like 1
FLJ22184
FOXC1 forkhead box C1
FPGS folylpolyglutamate synthase
FZD2 frizzled class receptor 2
GALE UDP-galactose-4-epimerase
GRTP1 growth hormone regulated TBC protein 1
HIRA histone cell cycle regulator
HIRIP3 HIRA interacting protein 3
HIST1H1D histone cluster 1, H1d
HIST1H4C histone cluster 1, H4c
HMHA1 histocompatibility (minor) HA-1
HMOX1 heme oxygenase 1
IRX4 iroquois homeobox 4
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCTD7 potassium channel tetramerization domain containing 7
KIAA1324 KIAA1324
KIF20B kinesin family member 20B
KIFC1 kinesin family member C1
LAGE3 L antigen family, member 3
LDB1 LIM domain binding 1
LHX6 LIM homeobox 6
LIME1 Lck interacting transmembrane adaptor 1
LINC00115 long intergenic non-protein coding RNA 115
LMNB1 lamin B1
LOC100287590 uncharacterized LOC100287590
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRP3 low density lipoprotein receptor-related protein 3
LY6D lymphocyte antigen 6 complex, locus D
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
METTL1 methyltransferase like 1
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MYO1F myosin IF
NARFL nuclear prelamin A recognition factor-like
NDRG4 NDRG family member 4
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OGFRL1 opioid growth factor receptor-like 1
PACS1 phosphofurin acidic cluster sorting protein 1
PADI1 peptidyl arginine deiminase, type I
PAGR1 PAXIP1 associated glutamate-rich protein 1
PC pyruvate carboxylase
PLAC8 placenta-specific 8
PLTP phospholipid transfer protein
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRR11 proline rich 11
PYCRL pyrroline-5-carboxylate reductase-like
RBM4B RNA binding motif protein 4B
RFPL3 ret finger protein-like 3
RNF126P1 ring finger protein 126 pseudogene 1
S100A2 S100 calcium binding protein A2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SNHG3 small nucleolar RNA host gene 3
SSBP3 single stranded DNA binding protein 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBX19 T-box 19
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TMEM121 transmembrane protein 121
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TUBG2 tubulin, gamma 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBTD1 ubiquitin domain containing 1
USP20 ubiquitin specific peptidase 20
VIPR1 vasoactive intestinal peptide receptor 1
VSIG10 V-set and immunoglobulin domain containing 10
ZBTB48 zinc finger and BTB domain containing 48
ZNF16 zinc finger protein 16
ZNF211 zinc finger protein 211
ZNF324 zinc finger protein 324
ZNF574 zinc finger protein 574