PNU-0251126-7388 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the PNU-0251126-7388 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGAP35 Rho GTPase activating protein 35
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARSB arylsulfatase B
ASTN2 astrotactin 2
ATAD5 ATPase family, AAA domain containing 5
ATP10A ATPase, class V, type 10A
C14ORF105 chromosome 14 open reading frame 105
C9ORF40 chromosome 9 open reading frame 40
CALML4 calmodulin-like 4
CASS4 Cas scaffolding protein family member 4
CD33 CD33 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CES2 carboxylesterase 2
CLDN11 claudin 11
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DENND2A DENN/MADD domain containing 2A
DFNB31 deafness, autosomal recessive 31
DPP4 dipeptidyl-peptidase 4
EED embryonic ectoderm development
EMID1 EMI domain containing 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ESRRG estrogen-related receptor gamma
ETV5 ets variant 5
EXOG endo/exonuclease (5'-3'), endonuclease G-like
FAM134B family with sequence similarity 134, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FOXN3 forkhead box N3
GLRB glycine receptor, beta
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPR137 G protein-coupled receptor 137
GTPBP1 GTP binding protein 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOXA4 homeobox A4
HOXC4 homeobox C4
IL17RA interleukin 17 receptor A
IL36RN interleukin 36 receptor antagonist
ING4 inhibitor of growth family, member 4
IQSEC2 IQ motif and Sec7 domain 2
KAZN kazrin, periplakin interacting protein
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA1644 KIAA1644
KLF4 Kruppel-like factor 4 (gut)
KRT6B keratin 6B, type II
LIMD2 LIM domain containing 2
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MIIP migration and invasion inhibitory protein
MUC3A mucin 3A, cell surface associated
NAIP NLR family, apoptosis inhibitory protein
NAT6 N-acetyltransferase 6 (GCN5-related)
NDOR1 NADPH dependent diflavin oxidoreductase 1
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PCOLCE procollagen C-endopeptidase enhancer
PDZK1 PDZ domain containing 1
PER3 period circadian clock 3
PGM5 phosphoglucomutase 5
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RNGTT RNA guanylyltransferase and 5'-phosphatase
RUSC2 RUN and SH3 domain containing 2
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SENP5 SUMO1/sentrin specific peptidase 5
SETD8 SET domain containing (lysine methyltransferase) 8
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC16A4 solute carrier family 16, member 4
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SYNGR1 synaptogyrin 1
TAOK2 TAO kinase 2
TAOK3 TAO kinase 3
TBCD tubulin folding cofactor D
TBX1 T-box 1
TK2 thymidine kinase 2, mitochondrial
TMEM242 transmembrane protein 242
TMEM70 transmembrane protein 70
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAF2 TNF receptor-associated factor 2
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TSNAXIP1 translin-associated factor X interacting protein 1
TTLL4 tubulin tyrosine ligase-like family member 4
UBE3B ubiquitin protein ligase E3B
WIPF1 WAS/WASL interacting protein family, member 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZNF197 zinc finger protein 197
ZNF276 zinc finger protein 276
ZNF428 zinc finger protein 428
ZNF606 zinc finger protein 606

decreased expression

Symbol Name
ADGRF1 adhesion G protein-coupled receptor F1
APH1B APH1B gamma secretase subunit
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATF7IP2 activating transcription factor 7 interacting protein 2
BAK1 BCL2-antagonist/killer 1
BDNF brain-derived neurotrophic factor
BIRC3 baculoviral IAP repeat containing 3
BORA bora, aurora kinase A activator
C1ORF159 chromosome 1 open reading frame 159
C1QTNF1 C1q and tumor necrosis factor related protein 1
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAPN5 calpain 5
CARD8 caspase recruitment domain family, member 8
CCNB1 cyclin B1
CDK3 cyclin-dependent kinase 3
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDON cell adhesion associated, oncogene regulated
CENPE centromere protein E, 312kDa
CEP112 centrosomal protein 112kDa
CFAP44 cilia and flagella associated protein 44
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN15 claudin 15
CLEC10A C-type lectin domain family 10, member A
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DEPDC1 DEP domain containing 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
ECM1 extracellular matrix protein 1
ELP6 elongator acetyltransferase complex subunit 6
EML4 echinoderm microtubule associated protein like 4
EN2 engrailed homeobox 2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EVPL envoplakin
F3 coagulation factor III (thromboplastin, tissue factor)
FAIM Fas apoptotic inhibitory molecule
FAM13B family with sequence similarity 13, member B
FLCN folliculin
FLRT3 fibronectin leucine rich transmembrane protein 3
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GAREM GRB2 associated, regulator of MAPK1
GLDC glycine dehydrogenase (decarboxylating)
HIST1H2AG histone cluster 1, H2ag
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BC histone cluster 1, H2bc
HMMR hyaluronan-mediated motility receptor (RHAMM)
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
IPO8 importin 8
IRF9 interferon regulatory factor 9
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD15 potassium channel tetramerization domain containing 15
KIF14 kinesin family member 14
KIF16B kinesin family member 16B
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
LNPEP leucyl/cystinyl aminopeptidase
LOC730101 uncharacterized LOC730101
LRRC61 leucine rich repeat containing 61
MEIS1 Meis homeobox 1
MGC12488
MOCS3 molybdenum cofactor synthesis 3
MTERF4 mitochondrial transcription termination factor 4
MYO1D myosin ID
NDE1 nudE neurodevelopment protein 1
NT5M 5',3'-nucleotidase, mitochondrial
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PLCD1 phospholipase C, delta 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLK1 polo-like kinase 1
PSRC1 proline/serine-rich coiled-coil 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RIN1 Ras and Rab interactor 1
RPGR retinitis pigmentosa GTPase regulator
RUNX1-IT1 RUNX1 intronic transcript 1
S100A3 S100 calcium binding protein A3
SCAMP5 secretory carrier membrane protein 5
SCARA3 scavenger receptor class A, member 3
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SPC25 SPC25, NDC80 kinetochore complex component
SPEG SPEG complex locus
SPRY2 sprouty homolog 2 (Drosophila)
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
TEP1 telomerase-associated protein 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM212 transmembrane protein 212
TMEM51 transmembrane protein 51
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM52 tripartite motif containing 52
URM1 ubiquitin related modifier 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZNF586 zinc finger protein 586
ZNF668 zinc finger protein 668
ZNF675 zinc finger protein 675