PML Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description promyelocytic leukemia|The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5371)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_PML
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Genes

143 co-expressed genes for PML from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACR acrosin
ADAM15 ADAM metallopeptidase domain 15
ADAMTSL2 ADAMTS-like 2
AGER advanced glycosylation end product-specific receptor
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD12 ankyrin repeat domain 12
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AQP5 aquaporin 5
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARC activity-regulated cytoskeleton-associated protein
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ARSE arylsulfatase E (chondrodysplasia punctata 1)
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
BAHD1 bromo adjacent homology domain containing 1
BCL2 B-cell CLL/lymphoma 2
BTD biotinidase
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CARD10 caspase recruitment domain family, member 10
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD40 CD40 molecule, TNF receptor superfamily member 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CNOT4 CCR4-NOT transcription complex, subunit 4
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CNTN2 contactin 2 (axonal)
CRCP CGRP receptor component
CRHR2 corticotropin releasing hormone receptor 2
CRYBA4 crystallin, beta A4
CSNK1D casein kinase 1, delta
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHRS1 dehydrogenase/reductase (SDR family) member 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DRG2 developmentally regulated GTP binding protein 2
EML3 echinoderm microtubule associated protein like 3
EPOR erythropoietin receptor
EXTL3 exostosin-like glycosyltransferase 3
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FAM189A2 family with sequence similarity 189, member A2
FAM189B family with sequence similarity 189, member B
FAM214B family with sequence similarity 214, member B
FANCG Fanconi anemia, complementation group G
FDXR ferredoxin reductase
FKBP15 FK506 binding protein 15, 133kDa
GGT5 gamma-glutamyltransferase 5
GHITM growth hormone inducible transmembrane protein
GPR161 G protein-coupled receptor 161
GPR35 G protein-coupled receptor 35
GRIK5 glutamate receptor, ionotropic, kainate 5
HAUS5 HAUS augmin-like complex, subunit 5
HMG20B high mobility group 20B
HMGXB3 HMG box domain containing 3
HSF4 heat shock transcription factor 4
HSPB2 heat shock 27kDa protein 2
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IFT140 intraflagellar transport 140
IGHMBP2 immunoglobulin mu binding protein 2
IGSF9B immunoglobulin superfamily, member 9B
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRF2 interferon regulatory factor 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGAV integrin, alpha V
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JAK3 Janus kinase 3
KAT8 K(lysine) acetyltransferase 8
KHNYN KH and NYN domain containing
KIAA0195 KIAA0195
KIFC3 kinesin family member C3
KLHL18 kelch-like family member 18
LBP lipopolysaccharide binding protein
LPAR2 lysophosphatidic acid receptor 2
LSM12 LSM12 homolog (S. cerevisiae)
LTK leukocyte receptor tyrosine kinase
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCM3AP minichromosome maintenance complex component 3 associated protein
MCRS1 microspherule protein 1
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MMP25 matrix metallopeptidase 25
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MR1 major histocompatibility complex, class I-related
MSX1 msh homeobox 1
MT4 metallothionein 4
MTX1 metaxin 1
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYO9B myosin IXB
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEURL1 neuralized E3 ubiquitin protein ligase 1
NFRKB nuclear factor related to kappaB binding protein
NTSR2 neurotensin receptor 2
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
PAX8 paired box 8
PCBP3 poly(rC) binding protein 3
PCGF1 polycomb group ring finger 1
PCGF2 polycomb group ring finger 2
PFDN1 prefoldin subunit 1
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLIN3 perilipin 3
PLK3 polo-like kinase 3
PMF1 polyamine-modulated factor 1
PML promyelocytic leukemia
PNMT phenylethanolamine N-methyltransferase
PPP1R10 protein phosphatase 1, regulatory subunit 10
PRKCSH protein kinase C substrate 80K-H
PRPH peripherin
PRSS16 protease, serine, 16 (thymus)
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PVT1 Pvt1 oncogene (non-protein coding)
RABAC1 Rab acceptor 1 (prenylated)
RABGGTA Rab geranylgeranyltransferase, alpha subunit
RBBP8 retinoblastoma binding protein 8
RBM8A RNA binding motif protein 8A
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SDC3 syndecan 3
SH2B1 SH2B adaptor protein 1
SIK3 SIK family kinase 3
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC22A24 solute carrier family 22, member 24
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SPEF1 sperm flagellar 1
SPTB spectrin, beta, erythrocytic
SSTR5 somatostatin receptor 5
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNP1 transition protein 1 (during histone to protamine replacement)
TPMT thiopurine S-methyltransferase
TRA2A transformer 2 alpha homolog (Drosophila)
TSPO2 translocator protein 2
TUB tubby bipartite transcription factor
TUBGCP2 tubulin, gamma complex associated protein 2
USP19 ubiquitin specific peptidase 19
WDR62 WD repeat domain 62
WWOX WW domain containing oxidoreductase
ZBED1 zinc finger, BED-type containing 1
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF592 zinc finger protein 592