PLC/PRF/5 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Human malignant liver hepatoma cell line; established from a 24-years-old human male. The line was originally contaminated with mycoplasma, and was cured by treatment with BM-cycline. The cells secrete HBsAg. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003492)
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Genes

309 genes mutated in the PLC/PRF/5 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AARS2 alanyl-tRNA synthetase 2, mitochondrial
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABR active BCR-related
ACIN1 apoptotic chromatin condensation inducer 1
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional)
AFTPH aftiphilin
AHDC1 AT hook, DNA binding motif, containing 1
AHNAK AHNAK nucleoprotein
AKAP1 A kinase (PRKA) anchor protein 1
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ANGEL1 angel homolog 1 (Drosophila)
ANGPTL6 angiopoietin-like 6
ANO8 anoctamin 8
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ARPC4-TTLL3 ARPC4-TTLL3 readthrough
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP11A ATPase, class VI, type 11A
ATP9B ATPase, class II, type 9B
ATR ATR serine/threonine kinase
BACE1 beta-site APP-cleaving enzyme 1
BAGE2 B melanoma antigen family, member 2
BAGE3 B melanoma antigen family, member 3
BAIAP3 BAI1-associated protein 3
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL2L1 BCL2-like 1
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
C11ORF96 chromosome 11 open reading frame 96
C17ORF80 chromosome 17 open reading frame 80
C1ORF105 chromosome 1 open reading frame 105
C1ORF106 chromosome 1 open reading frame 106
C2ORF42 chromosome 2 open reading frame 42
C2ORF69 chromosome 2 open reading frame 69
C9ORF69 chromosome 9 open reading frame 69
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCDC50 coiled-coil domain containing 50
CDC73 cell division cycle 73
CDH24 cadherin 24, type 2
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CEP192 centrosomal protein 192kDa
CEP250 centrosomal protein 250kDa
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGN cingulin
CHD1 chromodomain helicase DNA binding protein 1
CNBD2 cyclic nucleotide binding domain containing 2
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3
COL12A1 collagen, type XII, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A3 collagen, type V, alpha 3
COPS2 COP9 signalosome subunit 2
CTPS2 CTP synthase 2
CYFIP1 cytoplasmic FMR1 interacting protein 1
DCTN1 dynactin 1
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
DGCR6 DiGeorge syndrome critical region gene 6
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DLG1 discs, large homolog 1 (Drosophila)
DPYSL2 dihydropyrimidinase-like 2
DSCR4 Down syndrome critical region 4
DYM dymeclin
DYX1C1 dyslexia susceptibility 1 candidate 1
E2F2 E2F transcription factor 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELMO3 engulfment and cell motility 3
EMC7 ER membrane protein complex subunit 7
ETFA electron-transfer-flavoprotein, alpha polypeptide
ETV2 ets variant 2
EXT1 exostosin glycosyltransferase 1
FAM171B family with sequence similarity 171, member B
FAM193B family with sequence similarity 193, member B
FAM46B family with sequence similarity 46, member B
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FAT1 FAT atypical cadherin 1
FBXO10 F-box protein 10
FBXO27 F-box protein 27
FBXO34 F-box protein 34
FBXO41 F-box protein 41
FIBP fibroblast growth factor (acidic) intracellular binding protein
FMNL2 formin-like 2
FOXJ1 forkhead box J1
FOXK2 forkhead box K2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GAS2L1 growth arrest-specific 2 like 1
GIGYF2 GRB10 interacting GYF protein 2
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GOLIM4 golgi integral membrane protein 4
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GRB7 growth factor receptor-bound protein 7
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa
HDAC4 histone deacetylase 4
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPF heterogeneous nuclear ribonucleoprotein F
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSPG2 heparan sulfate proteoglycan 2
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IDUA iduronidase, alpha-L-
IER5 immediate early response 5
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1
INF2 inverted formin, FH2 and WH2 domain containing
INHBE inhibin, beta E
INTS9 integrator complex subunit 9
INTU inturned planar cell polarity protein
IQGAP3 IQ motif containing GTPase activating protein 3
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KAT2B K(lysine) acetyltransferase 2B
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KIAA0141 KIAA0141
KIAA0226 KIAA0226
KIF13B kinesin family member 13B
KIF18B kinesin family member 18B
KIRREL kin of IRRE like (Drosophila)
KMT2D lysine (K)-specific methyltransferase 2D
KRI1 KRI1 homolog (S. cerevisiae)
KRT20 keratin 20, type I
KSR2 kinase suppressor of ras 2
LARP1 La ribonucleoprotein domain family, member 1
LATS2 large tumor suppressor kinase 2
LMAN2 lectin, mannose-binding 2
LTA4H leukotriene A4 hydrolase
LTBP1 latent transforming growth factor beta binding protein 1
LYST lysosomal trafficking regulator
MAN2A1 mannosidase, alpha, class 2A, member 1
MCOLN3 mucolipin 3
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIPEP mitochondrial intermediate peptidase
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MRC2 mannose receptor, C type 2
MRPL22 mitochondrial ribosomal protein L22
MSANTD3 Myb/SANT-like DNA-binding domain containing 3
MTCL1 microtubule crosslinking factor 1
MTSS1L metastasis suppressor 1-like
MUC16 mucin 16, cell surface associated
MXRA7 matrix-remodelling associated 7
MYLK myosin light chain kinase
MYO1A myosin IA
N4BP2 NEDD4 binding protein 2
NCAM2 neural cell adhesion molecule 2
NDOR1 NADPH dependent diflavin oxidoreductase 1
NDRG2 NDRG family member 2
NEFH neurofilament, heavy polypeptide
NEURL4 neuralized E3 ubiquitin protein ligase 4
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NOA1 nitric oxide associated 1
NPHP3 nephronophthisis 3 (adolescent)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRG3 neuregulin 3
NSUN6 NOP2/Sun domain family, member 6
NUAK1 NUAK family, SNF1-like kinase, 1
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19
ORAI2 ORAI calcium release-activated calcium modulator 2
OTUD1 OTU deubiquitinase 1
PADI2 peptidyl arginine deiminase, type II
PAQR4 progestin and adipoQ receptor family member IV
PARP10 poly (ADP-ribose) polymerase family, member 10
PCDH10 protocadherin 10
PCLO piccolo presynaptic cytomatrix protein
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
PDE7B phosphodiesterase 7B
PDZD7 PDZ domain containing 7
PER1 period circadian clock 1
PES1 pescadillo ribosomal biogenesis factor 1
PHF20L1 PHD finger protein 20-like 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLEC plectin
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLSCR1 phospholipid scramblase 1
PLXNA4 plexin A4
PLXND1 plexin D1
PODXL podocalyxin-like
POLQ polymerase (DNA directed), theta
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POLR2D polymerase (RNA) II (DNA directed) polypeptide D
PPP1R37 protein phosphatase 1, regulatory subunit 37
PPT1 palmitoyl-protein thioesterase 1
PRC1 protein regulator of cytokinesis 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKD3 protein kinase D3
PRODH2 proline dehydrogenase (oxidase) 2
PRR12 proline rich 12
PRR19 proline rich 19
PRRC2B proline-rich coiled-coil 2B
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAD51AP1 RAD51 associated protein 1
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae)
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RIN1 Ras and Rab interactor 1
RNF114 ring finger protein 114
RNF213 ring finger protein 213
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRP1 ribosomal RNA processing 1
RUNX1 runt-related transcription factor 1
SACS sacsin molecular chaperone
SBF2 SET binding factor 2
SC5D sterol-C5-desaturase
SCAF1 SR-related CTD-associated factor 1
SDPR serum deprivation response
SEC31B SEC31 homolog B (S. cerevisiae)
SEPT10 septin 10
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHB Src homology 2 domain containing adaptor protein B
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SLC25A45 solute carrier family 25, member 45
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3
SLC35F5 solute carrier family 35, member F5
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC4A11 solute carrier family 4, sodium borate transporter, member 11
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLMO1 slowmo homolog 1 (Drosophila)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNX1 sorting nexin 1
SNX22 sorting nexin 22
SON SON DNA binding protein
SOS1 son of sevenless homolog 1 (Drosophila)
SPIDR scaffolding protein involved in DNA repair
SPTBN2 spectrin, beta, non-erythrocytic 2
STAG1 stromal antigen 1
STAG2 stromal antigen 2
STIL SCL/TAL1 interrupting locus
STK11 serine/threonine kinase 11
STOX2 storkhead box 2
STYK1 serine/threonine/tyrosine kinase 1
STYXL1 serine/threonine/tyrosine interacting-like 1
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SVIL supervillin
SYNM synemin, intermediate filament protein
SYT8 synaptotagmin VIII
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TACC2 transforming, acidic coiled-coil containing protein 2
TADA2A transcriptional adaptor 2A
TAOK2 TAO kinase 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBX2 T-box 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THAP4 THAP domain containing 4
THOC5 THO complex 5
TICAM1 toll-like receptor adaptor molecule 1
TLX3 T-cell leukemia homeobox 3
TM9SF3 transmembrane 9 superfamily member 3
TMBIM4 transmembrane BAX inhibitor motif containing 4
TMCC1 transmembrane and coiled-coil domain family 1
TNK2 tyrosine kinase, non-receptor, 2
TOE1 target of EGR1, member 1 (nuclear)
TP53 tumor protein p53
TRAPPC12 trafficking protein particle complex 12
TRIM58 tripartite motif containing 58
TRIP10 thyroid hormone receptor interactor 10
TRIP11 thyroid hormone receptor interactor 11
TRIP4 thyroid hormone receptor interactor 4
TSPAN12 tetraspanin 12
TSPAN15 tetraspanin 15
TSPYL2 TSPY-like 2
TTC25 tetratricopeptide repeat domain 25
TTYH3 tweety family member 3
TUFT1 tuftelin 1
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
TXNRD2 thioredoxin reductase 2
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP46 ubiquitin specific peptidase 46
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
UTRN utrophin
VARS valyl-tRNA synthetase
VIL1 villin 1
VIPR1 vasoactive intestinal peptide receptor 1
VWA8 von Willebrand factor A domain containing 8
WBSCR16 Williams-Beuren syndrome chromosome region 16
WDR54 WD repeat domain 54
WDR7 WD repeat domain 7
WDTC1 WD and tetratricopeptide repeats 1
WSCD1 WSC domain containing 1
ZBED4 zinc finger, BED-type containing 4
ZBTB44 zinc finger and BTB domain containing 44
ZC3H18 zinc finger CCCH-type containing 18
ZC3H4 zinc finger CCCH-type containing 4
ZFP62 ZFP62 zinc finger protein
ZFPM1 zinc finger protein, FOG family member 1
ZNF214 zinc finger protein 214
ZNF282 zinc finger protein 282
ZNF445 zinc finger protein 445
ZNF460 zinc finger protein 460
ZNF628 zinc finger protein 628
ZNF641 zinc finger protein 641
ZNF77 zinc finger protein 77
ZSWIM1 zinc finger, SWIM-type containing 1