PHA-00851261E-4333 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the PHA-00851261E-4333 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AADAC arylacetamide deacetylase
ACTN2 actinin, alpha 2
ACVR1B activin A receptor, type IB
ADAM28 ADAM metallopeptidase domain 28
ADD2 adducin 2 (beta)
AKAP8L A kinase (PRKA) anchor protein 8-like
ANGPT1 angiopoietin 1
ANKRD12 ankyrin repeat domain 12
APLP2 amyloid beta (A4) precursor-like protein 2
ASAP1-IT1 ASAP1 intronic transcript 1
ASPH aspartate beta-hydroxylase
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATXN7L3B ataxin 7-like 3B
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C1ORF95 chromosome 1 open reading frame 95
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CD52 CD52 molecule
CLEC4E C-type lectin domain family 4, member E
CLTCL1 clathrin, heavy chain-like 1
CNGA1 cyclic nucleotide gated channel alpha 1
CNTNAP2 contactin associated protein-like 2
CXXC4 CXXC finger protein 4
DLX2 distal-less homeobox 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DOC2B double C2-like domains, beta
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
ERN2 endoplasmic reticulum to nucleus signaling 2
ESR1 estrogen receptor 1
EZR ezrin
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXN2 forkhead box N2
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GGT1 gamma-glutamyltransferase 1
GJA4 gap junction protein, alpha 4, 37kDa
GPM6B glycoprotein M6B
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H3E histone cluster 1, H3e
HIST1H4C histone cluster 1, H4c
HIST1H4F histone cluster 1, H4f
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HPX hemopexin
IGFBP5 insulin-like growth factor binding protein 5
IL1RN interleukin 1 receptor antagonist
INO80D INO80 complex subunit D
KAT6A K(lysine) acetyltransferase 6A
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIAA0100 KIAA0100
KIRREL kin of IRRE like (Drosophila)
LMNB1 lamin B1
LOC157562 uncharacterized LOC157562
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAPK8 mitogen-activated protein kinase 8
MED1 mediator complex subunit 1
MED18 mediator complex subunit 18
MED25 mediator complex subunit 25
MET MET proto-oncogene, receptor tyrosine kinase
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NOP14-AS1 NOP14 antisense RNA 1
NOVA2 neuro-oncological ventral antigen 2
NPTX1 neuronal pentraxin I
NUMA1 nuclear mitotic apparatus protein 1
OLFML2B olfactomedin-like 2B
ONECUT2 one cut homeobox 2
PBX1 pre-B-cell leukemia homeobox 1
PHF3 PHD finger protein 3
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
RAB36 RAB36, member RAS oncogene family
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
REST RE1-silencing transcription factor
RET ret proto-oncogene
RNF122 ring finger protein 122
RNF43 ring finger protein 43
RPL13P5 ribosomal protein L13 pseudogene 5
SAYSD1 SAYSVFN motif domain containing 1
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SF1 splicing factor 1
SLC17A2 solute carrier family 17, member 2
SMC1A structural maintenance of chromosomes 1A
SP110 SP110 nuclear body protein
SRPK3 SRSF protein kinase 3
STAT4 signal transducer and activator of transcription 4
TBXA2R thromboxane A2 receptor
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
THRA thyroid hormone receptor, alpha
TM4SF4 transmembrane 4 L six family member 4
TM6SF1 transmembrane 6 superfamily member 1
UGCG UDP-glucose ceramide glucosyltransferase
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
WIZ widely interspaced zinc finger motifs
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
AFF4 AF4/FMR2 family, member 4
AHDC1 AT hook, DNA binding motif, containing 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
AXIN1 axin 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BTF3P12 basic transcription factor 3 pseudogene 12
C17ORF80 chromosome 17 open reading frame 80
CAPN15 calpain 15
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX4 chromobox homolog 4
CCDC106 coiled-coil domain containing 106
CCDC88C coiled-coil domain containing 88C
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD53 CD53 molecule
CES3 carboxylesterase 3
CGREF1 cell growth regulator with EF-hand domain 1
CISH cytokine inducible SH2-containing protein
DBF4B DBF4 zinc finger B
DEF6 differentially expressed in FDCP 6 homolog (mouse)
EFNB1 ephrin-B1
EN1 engrailed homeobox 1
ERCC2 excision repair cross-complementation group 2
EXOC5 exocyst complex component 5
FZD10 frizzled class receptor 10
GBX2 gastrulation brain homeobox 2
GDAP1 ganglioside induced differentiation associated protein 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GTF2I general transcription factor IIi
HOXC10 homeobox C10
HOXC11 homeobox C11
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNA17 interferon, alpha 17
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL22 interleukin 22
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLC2 kinesin light chain 2
LINC00115 long intergenic non-protein coding RNA 115
LRRC61 leucine rich repeat containing 61
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAPK3 mitogen-activated protein kinase 3
MATN3 matrilin 3
MBTPS2 membrane-bound transcription factor peptidase, site 2
MFGE8 milk fat globule-EGF factor 8 protein
MYO1D myosin ID
NPIPB3 nuclear pore complex interacting protein family, member B3
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OSBP2 oxysterol binding protein 2
PCOLCE procollagen C-endopeptidase enhancer
PDE8B phosphodiesterase 8B
PILRB paired immunoglobin-like type 2 receptor beta
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRSS53 protease, serine, 53
PSAT1 phosphoserine aminotransferase 1
PTPRS protein tyrosine phosphatase, receptor type, S
R3HCC1L R3H domain and coiled-coil containing 1-like
RHOBTB2 Rho-related BTB domain containing 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF146 ring finger protein 146
RUSC2 RUN and SH3 domain containing 2
S1PR1 sphingosine-1-phosphate receptor 1
SAMD9 sterile alpha motif domain containing 9
SERGEF secretion regulating guanine nucleotide exchange factor
SETBP1 SET binding protein 1
SETD1A SET domain containing 1A
SETD8 SET domain containing (lysine methyltransferase) 8
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SSBP3 single stranded DNA binding protein 3
STRA6 stimulated by retinoic acid 6
STRN4 striatin, calmodulin binding protein 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYCP2 synaptonemal complex protein 2
SYTL2 synaptotagmin-like 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THRAP3 thyroid hormone receptor associated protein 3
TMEM8A transmembrane protein 8A
TMEM8B transmembrane protein 8B
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRABD TraB domain containing
TSC22D4 TSC22 domain family, member 4
TTC30A tetratricopeptide repeat domain 30A
TWSG1 twisted gastrulation BMP signaling modulator 1
USP6 ubiquitin specific peptidase 6
UTRN utrophin
VEGFB vascular endothelial growth factor B
WDR25 WD repeat domain 25
ZNF10 zinc finger protein 10
ZNF155 zinc finger protein 155
ZNF711 zinc finger protein 711
ZNF76 zinc finger protein 76