PHA-00851261E-3965 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the PHA-00851261E-3965 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACTA1 actin, alpha 1, skeletal muscle
AKAP5 A kinase (PRKA) anchor protein 5
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
APOLD1 apolipoprotein L domain containing 1
C11ORF16 chromosome 11 open reading frame 16
C1ORF21 chromosome 1 open reading frame 21
C4BPA complement component 4 binding protein, alpha
CARD14 caspase recruitment domain family, member 14
CCDC81 coiled-coil domain containing 81
CCL19 chemokine (C-C motif) ligand 19
CDIP1 cell death-inducing p53 target 1
CLDN16 claudin 16
CLEC2D C-type lectin domain family 2, member D
CLSTN3 calsyntenin 3
COL1A1 collagen, type I, alpha 1
COL9A3 collagen, type IX, alpha 3
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18
DEFA5 defensin, alpha 5, Paneth cell-specific
DENND5B DENN/MADD domain containing 5B
DGAT1 diacylglycerol O-acyltransferase 1
DGKG diacylglycerol kinase, gamma 90kDa
EHD2 EH-domain containing 2
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EML2 echinoderm microtubule associated protein like 2
FAXDC2 fatty acid hydroxylase domain containing 2
FHL3 four and a half LIM domains 3
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GFI1 growth factor independent 1 transcription repressor
GPR21 G protein-coupled receptor 21
HMG20B high mobility group 20B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HYAL3 hyaluronoglucosaminidase 3
IDI2-AS1 IDI2 antisense RNA 1
IFIH1 interferon induced with helicase C domain 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IQCC IQ motif containing C
KANK3 KN motif and ankyrin repeat domains 3
KREMEN2 kringle containing transmembrane protein 2
LHX3 LIM homeobox 3
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LIME1 Lck interacting transmembrane adaptor 1
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAOA monoamine oxidase A
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MCM3AP minichromosome maintenance complex component 3 associated protein
MIER2 mesoderm induction early response 1, family member 2
MST1R macrophage stimulating 1 receptor
MYL4 myosin, light chain 4, alkali; atrial, embryonic
N4BP2L2 NEDD4 binding protein 2-like 2
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NEK9 NIMA-related kinase 9
NEU2 sialidase 2 (cytosolic sialidase)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NR2E3 nuclear receptor subfamily 2, group E, member 3
NUP88 nucleoporin 88kDa
NUPR1 nuclear protein, transcriptional regulator, 1
NXF2 nuclear RNA export factor 2
NYNRIN NYN domain and retroviral integrase containing
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PKP1 plakophilin 1
PLCD1 phospholipase C, delta 1
PLK3 polo-like kinase 3
PPARD peroxisome proliferator-activated receptor delta
PRM1 protamine 1
PRSS53 protease, serine, 53
PTGDR2 prostaglandin D2 receptor 2
RBMS2 RNA binding motif, single stranded interacting protein 2
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SAFB scaffold attachment factor B
SH3PXD2A SH3 and PX domains 2A
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SMIM7 small integral membrane protein 7
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STIM1 stromal interaction molecule 1
STOML1 stomatin (EPB72)-like 1
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TAZ tafazzin
TMOD1 tropomodulin 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TREM1 triggering receptor expressed on myeloid cells 1
TSC2 tuberous sclerosis 2
UCN urocortin
ZG16 zymogen granule protein 16
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ABHD17B abhydrolase domain containing 17B
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACPP acid phosphatase, prostate
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARMCX5 armadillo repeat containing, X-linked 5
ASIC1 acid sensing (proton gated) ion channel 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
C10ORF95 chromosome 10 open reading frame 95
C11ORF63 chromosome 11 open reading frame 63
C17ORF53 chromosome 17 open reading frame 53
C5AR2 complement component 5a receptor 2
CA11 carbonic anhydrase XI
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC68 coiled-coil domain containing 68
CCNO cyclin O
CDON cell adhesion associated, oncogene regulated
CEMIP cell migration inducing protein, hyaluronan binding
CHM choroideremia (Rab escort protein 1)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC4E C-type lectin domain family 4, member E
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EDAR ectodysplasin A receptor
ERCC6 excision repair cross-complementation group 6
FAM46C family with sequence similarity 46, member C
FAM76A family with sequence similarity 76, member A
FLJ22184
FOXD1 forkhead box D1
GEMIN8 gem (nuclear organelle) associated protein 8
GMPR guanosine monophosphate reductase
GPR157 G protein-coupled receptor 157
GPRC5D G protein-coupled receptor, class C, group 5, member D
GSTTP1 glutathione S-transferase theta pseudogene 1
HIST1H2BM histone cluster 1, H2bm
HIST1H4E histone cluster 1, H4e
HOXA4 homeobox A4
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IFI35 interferon-induced protein 35
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLHL28 kelch-like family member 28
LAX1 lymphocyte transmembrane adaptor 1
LHX1 LIM homeobox 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MRPL41 mitochondrial ribosomal protein L41
MTCL1 microtubule crosslinking factor 1
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NELL2 NEL-like 2 (chicken)
NIPAL2 NIPA-like domain containing 2
NSUN6 NOP2/Sun domain family, member 6
NT5DC3 5'-nucleotidase domain containing 3
NXPE3 neurexophilin and PC-esterase domain family, member 3
OCA2 oculocutaneous albinism II
PCDHB3 protocadherin beta 3
PGBD5 piggyBac transposable element derived 5
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLSCR4 phospholipid scramblase 4
POLM polymerase (DNA directed), mu
POMT2 protein-O-mannosyltransferase 2
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
RCAN3 RCAN family member 3
RCOR3 REST corepressor 3
RFXAP regulatory factor X-associated protein
RHBG Rh family, B glycoprotein (gene/pseudogene)
RHOBTB2 Rho-related BTB domain containing 2
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RND1 Rho family GTPase 1
SAG S-antigen; retina and pineal gland (arrestin)
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SENP7 SUMO1/sentrin specific peptidase 7
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
STAG3 stromal antigen 3
STARD13 StAR-related lipid transfer (START) domain containing 13
STRN striatin, calmodulin binding protein
SYBU syntabulin (syntaxin-interacting)
SYCP2 synaptonemal complex protein 2
THRAP3 thyroid hormone receptor associated protein 3
TM4SF4 transmembrane 4 L six family member 4
TMCC2 transmembrane and coiled-coil domain family 2
TMEM8B transmembrane protein 8B
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRAIP TRAF interacting protein
TSNAXIP1 translin-associated factor X interacting protein 1
USP19 ubiquitin specific peptidase 19
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
ZNF484 zinc finger protein 484
ZNF532 zinc finger protein 532
ZSWIM1 zinc finger, SWIM-type containing 1