PHA-00851261E-3857 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the PHA-00851261E-3857 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADGRA2 adhesion G protein-coupled receptor A2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALOX12 arachidonate 12-lipoxygenase
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BEGAIN brain-enriched guanylate kinase-associated
C1ORF61 chromosome 1 open reading frame 61
CALCR calcitonin receptor
CCDC134 coiled-coil domain containing 134
CD7 CD7 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CDRT1 CMT1A duplicated region transcript 1
CFHR4 complement factor H-related 4
CREBZF CREB/ATF bZIP transcription factor
CRIP1 cysteine-rich protein 1 (intestinal)
CRMP1 collapsin response mediator protein 1
CTSE cathepsin E
CUZD1 CUB and zona pellucida-like domains 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK3 death-associated protein kinase 3
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DGAT1 diacylglycerol O-acyltransferase 1
DGCR8 DGCR8 microprocessor complex subunit
DHRS12 dehydrogenase/reductase (SDR family) member 12
DPF1 D4, zinc and double PHD fingers family 1
DPY19L1 dpy-19-like 1 (C. elegans)
DTX3 deltex 3, E3 ubiquitin ligase
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ELOVL5 ELOVL fatty acid elongase 5
ESR1 estrogen receptor 1
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGF13 fibroblast growth factor 13
FKRP fukutin related protein
FLOT1 flotillin 1
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GM2A GM2 ganglioside activator
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM2 intercellular adhesion molecule 2
INHBC inhibin, beta C
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAPK7 mitogen-activated protein kinase 7
MCL1 myeloid cell leukemia 1
MCTP1 multiple C2 domains, transmembrane 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
METTL16 methyltransferase like 16
MFAP5 microfibrillar associated protein 5
MFGE8 milk fat globule-EGF factor 8 protein
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MRC2 mannose receptor, C type 2
MTMR3 myotubularin related protein 3
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NCOR2 nuclear receptor corepressor 2
NF1 neurofibromin 1
NPM3 nucleophosmin/nucleoplasmin 3
NPR1 natriuretic peptide receptor 1
OMG oligodendrocyte myelin glycoprotein
PCDH8 protocadherin 8
PDE12 phosphodiesterase 12
PGR progesterone receptor
PHEX phosphate regulating endopeptidase homolog, X-linked
PKNOX1 PBX/knotted 1 homeobox 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLXNB3 plexin B3
PRMT2 protein arginine methyltransferase 2
PSCA prostate stem cell antigen
RAB5C RAB5C, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RBL2 retinoblastoma-like 2
RND1 Rho family GTPase 1
RPL35A ribosomal protein L35a
RSG1 REM2 and RAB-like small GTPase 1
SETD1B SET domain containing 1B
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SMG6 SMG6 nonsense mediated mRNA decay factor
SP1 Sp1 transcription factor
STAT5A signal transducer and activator of transcription 5A
T T, brachyury homolog (mouse)
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE4 transducin-like enhancer of split 4
TLR5 toll-like receptor 5
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TPP1 tripeptidyl peptidase I
TRAF4 TNF receptor-associated factor 4
TRIM3 tripartite motif containing 3
TTLL1 tubulin tyrosine ligase-like family member 1
TTLL4 tubulin tyrosine ligase-like family member 4
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VILL villin-like

decreased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ADAP2 ArfGAP with dual PH domains 2
ADGRE5 adhesion G protein-coupled receptor E5
AKAP12 A kinase (PRKA) anchor protein 12
AMH anti-Mullerian hormone
ANKH ANKH inorganic pyrophosphate transport regulator
ANP32A-IT1 ANP32A intronic transcript 1
ARR3 arrestin 3, retinal (X-arrestin)
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C2ORF27A chromosome 2 open reading frame 27A
C4ORF29 chromosome 4 open reading frame 29
C5AR2 complement component 5a receptor 2
CALML5 calmodulin-like 5
CCDC71 coiled-coil domain containing 71
CD80 CD80 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEMIP cell migration inducing protein, hyaluronan binding
CGA glycoprotein hormones, alpha polypeptide
CGREF1 cell growth regulator with EF-hand domain 1
CSTA cystatin A (stefin A)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DYM dymeclin
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENOX1 ecto-NOX disulfide-thiol exchanger 1
EPHB6 EPH receptor B6
FAM76A family with sequence similarity 76, member A
FGF23 fibroblast growth factor 23
FGF4 fibroblast growth factor 4
FXYD5 FXYD domain containing ion transport regulator 5
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLB1L galactosidase, beta 1-like
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR27 G protein-coupled receptor 27
GUSBP3 glucuronidase, beta pseudogene 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1B histone cluster 1, H1b
HIST1H4C histone cluster 1, H4c
HMOX1 heme oxygenase 1
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFI6 interferon, alpha-inducible protein 6
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL22 interleukin 22
IRF6 interferon regulatory factor 6
JMJD4 jumonji domain containing 4
KCNK12 potassium channel, two pore domain subfamily K, member 12
KIAA0319L KIAA0319-like
KIAA0894 KIAA0894 protein
KIAA1107 KIAA1107
LAMA3 laminin, alpha 3
LARP6 La ribonucleoprotein domain family, member 6
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC37A3 leucine rich repeat containing 37, member A3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MRPL52 mitochondrial ribosomal protein L52
MTA2 metastasis associated 1 family, member 2
MYBBP1A MYB binding protein (P160) 1a
NXPE3 neurexophilin and PC-esterase domain family, member 3
PCDHGA8 protocadherin gamma subfamily A, 8
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRR4 proline rich 4 (lacrimal)
PVRL3 poliovirus receptor-related 3
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
SCAI suppressor of cancer cell invasion
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SLPI secretory leukocyte peptidase inhibitor
SND1-IT1 SND1 intronic transcript 1
STARD8 StAR-related lipid transfer (START) domain containing 8
STON1 stonin 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THRAP3 thyroid hormone receptor associated protein 3
TRIM68 tripartite motif containing 68
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSPYL2 TSPY-like 2
TUBA4B tubulin, alpha 4b
TYRP1 tyrosinase-related protein 1
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF358 zinc finger protein 358
ZNF442 zinc finger protein 442
ZNF532 zinc finger protein 532
ZNF652 zinc finger protein 652
ZNF862 zinc finger protein 862
ZSCAN2 zinc finger and SCAN domain containing 2