PHA-00851261E-3773 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the PHA-00851261E-3773 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACE angiotensin I converting enzyme
ACOT11 acyl-CoA thioesterase 11
ADD1 adducin 1 (alpha)
ALOX5 arachidonate 5-lipoxygenase
ALPK1 alpha-kinase 1
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ASGR2 asialoglycoprotein receptor 2
ATF6B activating transcription factor 6 beta
ATP10B ATPase, class V, type 10B
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BLZF1 basic leucine zipper nuclear factor 1
BMP5 bone morphogenetic protein 5
BTBD7 BTB (POZ) domain containing 7
CA5B carbonic anhydrase VB, mitochondrial
CAPN3 calpain 3, (p94)
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD300C CD300c molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CNOT2 CCR4-NOT transcription complex, subunit 2
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DLC1 DLC1 Rho GTPase activating protein
DSC2 desmocollin 2
EFCAB6 EF-hand calcium binding domain 6
EGR4 early growth response 4
EXOSC2 exosome component 2
FAIM2 Fas apoptotic inhibitory molecule 2
FAM13C family with sequence similarity 13, member C
FASLG Fas ligand (TNF superfamily, member 6)
FGA fibrinogen alpha chain
FGF22 fibroblast growth factor 22
FLJ11292
FOSL2 FOS-like antigen 2
G6PC2 glucose-6-phosphatase, catalytic, 2
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GPR85 G protein-coupled receptor 85
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
HCRP1 hepatocellular carcinoma-related HCRP1
HIST1H1D histone cluster 1, H1d
HIST1H1T histone cluster 1, H1t
HIST1H2BN histone cluster 1, H2bn
ITGA8 integrin, alpha 8
KIF1C kinesin family member 1C
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KLK12 kallikrein-related peptidase 12
KLRC4 killer cell lectin-like receptor subfamily C, member 4
KMT2A lysine (K)-specific methyltransferase 2A
KRT33A keratin 33A, type I
LAMA2 laminin, alpha 2
LATS1 large tumor suppressor kinase 1
LEF1 lymphoid enhancer-binding factor 1
LGALS4 lectin, galactoside-binding, soluble, 4
LY6D lymphocyte antigen 6 complex, locus D
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAPK10 mitogen-activated protein kinase 10
MRC2 mannose receptor, C type 2
NCR2 natural cytotoxicity triggering receptor 2
NDRG2 NDRG family member 2
NF1 neurofibromin 1
NMT2 N-myristoyltransferase 2
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR0B1 nuclear receptor subfamily 0, group B, member 1
NUMA1 nuclear mitotic apparatus protein 1
PAX8 paired box 8
PHF3 PHD finger protein 3
PLK3 polo-like kinase 3
PLXNA2 plexin A2
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRDM1 PR domain containing 1, with ZNF domain
PSME4 proteasome (prosome, macropain) activator subunit 4
PTAFR platelet-activating factor receptor
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RAPSN receptor-associated protein of the synapse
RIMS1 regulating synaptic membrane exocytosis 1
RNF17 ring finger protein 17
RNGTT RNA guanylyltransferase and 5'-phosphatase
RPL7 ribosomal protein L7
RPLP2 ribosomal protein, large, P2
RRAD Ras-related associated with diabetes
S100A12 S100 calcium binding protein A12
SKIL SKI-like proto-oncogene
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SPRR2B small proline-rich protein 2B
STK24 serine/threonine kinase 24
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TEF thyrotrophic embryonic factor
TG thyroglobulin
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TRIM3 tripartite motif containing 3
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
USP9Y ubiquitin specific peptidase 9, Y-linked
WSB1 WD repeat and SOCS box containing 1
ZNF223 zinc finger protein 223
ZNF3 zinc finger protein 3

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD17B abhydrolase domain containing 17B
ADCY6 adenylate cyclase 6
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARMC4 armadillo repeat containing 4
ARMC6 armadillo repeat containing 6
ARSB arylsulfatase B
BAHCC1 BAH domain and coiled-coil containing 1
BCAS3 breast carcinoma amplified sequence 3
C1R complement component 1, r subcomponent
CA9 carbonic anhydrase IX
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDK3 cyclin-dependent kinase 3
CHM choroideremia (Rab escort protein 1)
CLEC2B C-type lectin domain family 2, member B
CLIC3 chloride intracellular channel 3
CPNE7 copine VII
CRELD1 cysteine-rich with EGF-like domains 1
CRMP1 collapsin response mediator protein 1
DAPK3 death-associated protein kinase 3
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
FAM188A family with sequence similarity 188, member A
FBXO2 F-box protein 2
FBXO31 F-box protein 31
FUZ fuzzy planar cell polarity protein
FZD8 frizzled class receptor 8
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GK3P glycerol kinase 3 pseudogene
GNA13 guanine nucleotide binding protein (G protein), alpha 13
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HIST1H4D histone cluster 1, H4d
HMBOX1 homeobox containing 1
HOXB2 homeobox B2
HOXC11 homeobox C11
HOXC4 homeobox C4
IL12A interleukin 12A
IMPAD1 inositol monophosphatase domain containing 1
INO80D INO80 complex subunit D
IREB2 iron-responsive element binding protein 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
KLHL28 kelch-like family member 28
KRT37 keratin 37, type I
LINC00341 long intergenic non-protein coding RNA 341
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCOLN1 mucolipin 1
MCTP2 multiple C2 domains, transmembrane 2
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NGF nerve growth factor (beta polypeptide)
NLGN1 neuroligin 1
NOL12 nucleolar protein 12
OGDHL oxoglutarate dehydrogenase-like
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PALMD palmdelphin
PAQR5 progestin and adipoQ receptor family member V
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS22 protease, serine, 22
QPCTL glutaminyl-peptide cyclotransferase-like
R3HCC1L R3H domain and coiled-coil containing 1-like
RNF146 ring finger protein 146
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCEL sciellin
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK2 serum/glucocorticoid regulated kinase 2
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SND1-IT1 SND1 intronic transcript 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STRN striatin, calmodulin binding protein
STXBP5L syntaxin binding protein 5-like
SUSD4 sushi domain containing 4
THRB thyroid hormone receptor, beta
TIGD6 tigger transposable element derived 6
TRIM25 tripartite motif containing 25
TSPAN32 tetraspanin 32
UNC119 unc-119 homolog (C. elegans)
VGF VGF nerve growth factor inducible
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZBTB6 zinc finger and BTB domain containing 6
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF214 zinc finger protein 214
ZNF230 zinc finger protein 230
ZNF254 zinc finger protein 254
ZNF442 zinc finger protein 442
ZNF510 zinc finger protein 510
ZNF573 zinc finger protein 573
ZNF701 zinc finger protein 701