PHA-00846566E-7086 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the PHA-00846566E-7086 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGFG2 ArfGAP with FG repeats 2
AKR1C1 aldo-keto reductase family 1, member C1
ANAPC5 anaphase promoting complex subunit 5
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRB2 arrestin, beta 2
ASRGL1 asparaginase like 1
ATF7IP activating transcription factor 7 interacting protein
ATP11A ATPase, class VI, type 11A
BBS4 Bardet-Biedl syndrome 4
BTN3A2 butyrophilin, subfamily 3, member A2
C9ORF114 chromosome 9 open reading frame 114
CCPG1 cell cycle progression 1
CDC5L cell division cycle 5-like
CENPI centromere protein I
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN3 claudin 3
COBLL1 cordon-bleu WH2 repeat protein-like 1
COG5 component of oligomeric golgi complex 5
CPT2 carnitine palmitoyltransferase 2
CUL5 cullin 5
DBT dihydrolipoamide branched chain transacylase E2
DSTYK dual serine/threonine and tyrosine protein kinase
DUS2 dihydrouridine synthase 2
EPOR erythropoietin receptor
ERCC2 excision repair cross-complementation group 2
F2R coagulation factor II (thrombin) receptor
FADS2 fatty acid desaturase 2
FAM49B family with sequence similarity 49, member B
FANCA Fanconi anemia, complementation group A
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GCFC2 GC-rich sequence DNA-binding factor 2
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GUSBP3 glucuronidase, beta pseudogene 3
HS1BP3 HCLS1 binding protein 3
HTT huntingtin
IFI30 interferon, gamma-inducible protein 30
IFI44L interferon-induced protein 44-like
IL17RA interleukin 17 receptor A
KLHL24 kelch-like family member 24
LARP4B La ribonucleoprotein domain family, member 4B
LIMK1 LIM domain kinase 1
LMNB1 lamin B1
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MAP1B microtubule-associated protein 1B
MARS methionyl-tRNA synthetase
MBD3 methyl-CpG binding domain protein 3
MBTD1 mbt domain containing 1
MDFI MyoD family inhibitor
METTL1 methyltransferase like 1
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MYLK myosin light chain kinase
NBPF10 neuroblastoma breakpoint family, member 10
NRSN2 neurensin 2
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
OSBPL2 oxysterol binding protein-like 2
PLCE1 phospholipase C, epsilon 1
POMT2 protein-O-mannosyltransferase 2
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PREPL prolyl endopeptidase-like
RAB29 RAB29, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RBM19 RNA binding motif protein 19
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBM4 RNA binding motif protein 4
RPL23 ribosomal protein L23
SAMD9 sterile alpha motif domain containing 9
SCAPER S-phase cyclin A-associated protein in the ER
SETD1B SET domain containing 1B
SIK3 SIK family kinase 3
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLMO2 slowmo homolog 2 (Drosophila)
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMC1A structural maintenance of chromosomes 1A
SNRK SNF related kinase
SPATA2L spermatogenesis associated 2-like
ST14 suppression of tumorigenicity 14 (colon carcinoma)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TCF3 transcription factor 3
TDRD3 tudor domain containing 3
TESK2 testis-specific kinase 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TTF1 transcription termination factor, RNA polymerase I
URI1 URI1, prefoldin-like chaperone
USP15 ubiquitin specific peptidase 15
WAS Wiskott-Aldrich syndrome
WDHD1 WD repeat and HMG-box DNA binding protein 1
WDR13 WD repeat domain 13
ZBTB43 zinc finger and BTB domain containing 43
ZNF174 zinc finger protein 174
ZNF385D zinc finger protein 385D
ZNF665 zinc finger protein 665

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ANKRD40 ankyrin repeat domain 40
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APH1B APH1B gamma secretase subunit
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASB13 ankyrin repeat and SOCS box containing 13
AUP1 ancient ubiquitous protein 1
BAMBI BMP and activin membrane-bound inhibitor
BCAS3 breast carcinoma amplified sequence 3
BCAS4 breast carcinoma amplified sequence 4
BOLA1 bolA family member 1
C16ORF59 chromosome 16 open reading frame 59
C8ORF60 chromosome 8 open reading frame 60
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CADPS2 Ca++-dependent secretion activator 2
CCDC94 coiled-coil domain containing 94
CCNO cyclin O
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CNTNAP1 contactin associated protein 1
CRELD1 cysteine-rich with EGF-like domains 1
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DMTN dematin actin binding protein
ECI1 enoyl-CoA delta isomerase 1
EPPK1 epiplakin 1
FAM160B2 family with sequence similarity 160, member B2
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXL15 F-box and leucine-rich repeat protein 15
FHOD1 formin homology 2 domain containing 1
FIG4 FIG4 phosphoinositide 5-phosphatase
FZD2 frizzled class receptor 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GATA3 GATA binding protein 3
GPX2 glutathione peroxidase 2
GRPR gastrin-releasing peptide receptor
HIST1H2AI histone cluster 1, H2ai
HIST1H2BI histone cluster 1, H2bi
HOXA4 homeobox A4
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INF2 inverted formin, FH2 and WH2 domain containing
KDM7A lysine (K)-specific demethylase 7A
KIF3A kinesin family member 3A
KLHL36 kelch-like family member 36
KPTN kaptin (actin binding protein)
LIG4 ligase IV, DNA, ATP-dependent
LINC00597 long intergenic non-protein coding RNA 597
LNPEP leucyl/cystinyl aminopeptidase
LPAR6 lysophosphatidic acid receptor 6
LYPD3 LY6/PLAUR domain containing 3
MAGEH1 melanoma antigen family H1
MGMT O-6-methylguanine-DNA methyltransferase
MICALL2 MICAL-like 2
MRPL28 mitochondrial ribosomal protein L28
NPM3 nucleophosmin/nucleoplasmin 3
NR3C2 nuclear receptor subfamily 3, group C, member 2
NSUN6 NOP2/Sun domain family, member 6
NT5C 5', 3'-nucleotidase, cytosolic
OVGP1 oviductal glycoprotein 1, 120kDa
PAIP2B poly(A) binding protein interacting protein 2B
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PCBP4 poly(rC) binding protein 4
PCOLCE procollagen C-endopeptidase enhancer
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLXNB3 plexin B3
POMT1 protein-O-mannosyltransferase 1
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRR15L proline rich 15-like
PRSS22 protease, serine, 22
PSENEN presenilin enhancer gamma secretase subunit
PTCD1 pentatricopeptide repeat domain 1
RAB36 RAB36, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIRT2 sirtuin 2
SIRT6 sirtuin 6
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC41A3 solute carrier family 41, member 3
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPANXC SPANX family, member C
SPEG SPEG complex locus
STBD1 starch binding domain 1
TH tyrosine hydroxylase
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TPD52L1 tumor protein D52-like 1
TPST2 tyrosylprotein sulfotransferase 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBG2 tubulin, gamma 2
ZNF358 zinc finger protein 358
ZNF606 zinc finger protein 606