PHA-00846566E-7081 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the PHA-00846566E-7081 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AK2 adenylate kinase 2
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALMS1 Alstrom syndrome protein 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARMC8 armadillo repeat containing 8
ARNT aryl hydrocarbon receptor nuclear translocator
ATP11A ATPase, class VI, type 11A
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BMP7 bone morphogenetic protein 7
BRAP BRCA1 associated protein
CACTIN cactin, spliceosome C complex subunit
CBX7 chromobox homolog 7
CC2D1A coiled-coil and C2 domain containing 1A
CD46 CD46 molecule, complement regulatory protein
CEP85 centrosomal protein 85kDa
COPA coatomer protein complex, subunit alpha
CSE1L CSE1 chromosome segregation 1-like (yeast)
CUL7 cullin 7
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
EFCAB2 EF-hand calcium binding domain 2
EFNA3 ephrin-A3
ELL elongation factor RNA polymerase II
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FEM1B fem-1 homolog b (C. elegans)
FLJ10038 uncharacterized protein FLJ10038
FMOD fibromodulin
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GOLIM4 golgi integral membrane protein 4
HABP4 hyaluronan binding protein 4
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLA-G major histocompatibility complex, class I, G
HYAL2 hyaluronoglucosaminidase 2
IGHMBP2 immunoglobulin mu binding protein 2
INF2 inverted formin, FH2 and WH2 domain containing
IRF5 interferon regulatory factor 5
JAM3 junctional adhesion molecule 3
JRKL JRK-like
JUN jun proto-oncogene
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KLK13 kallikrein-related peptidase 13
LENEP lens epithelial protein
LOC399491
LOC647070 uncharacterized LOC647070
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARK2 MAP/microtubule affinity-regulating kinase 2
MED25 mediator complex subunit 25
MMP17 matrix metallopeptidase 17 (membrane-inserted)
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
PACS1 phosphofurin acidic cluster sorting protein 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCGF2 polycomb group ring finger 2
PDE9A phosphodiesterase 9A
PDPK1 3-phosphoinositide dependent protein kinase 1
PHF3 PHD finger protein 3
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLSCR3 phospholipid scramblase 3
POFUT1 protein O-fucosyltransferase 1
PRPH peripherin
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAD50 RAD50 homolog (S. cerevisiae)
RAD51B RAD51 paralog B
RANGRF RAN guanine nucleotide release factor
RGS10 regulator of G-protein signaling 10
RPL23AP32 ribosomal protein L23a pseudogene 32
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RSL1D1 ribosomal L1 domain containing 1
SCARB1 scavenger receptor class B, member 1
SETD6 SET domain containing 6
SGCE sarcoglycan, epsilon
SH3BP2 SH3-domain binding protein 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIVA1 SIVA1, apoptosis-inducing factor
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLCO3A1 solute carrier organic anion transporter family, member 3A1
ST7 suppression of tumorigenicity 7
STAT5B signal transducer and activator of transcription 5B
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
TAOK1 TAO kinase 1
TAPBP TAP binding protein (tapasin)
TMEM63A transmembrane protein 63A
TOP3A topoisomerase (DNA) III alpha
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSPAN9 tetraspanin 9
TTC38 tetratricopeptide repeat domain 38
TTI1 TELO2 interacting protein 1
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBOX5 U-box domain containing 5
USP22 ubiquitin specific peptidase 22
WSB1 WD repeat and SOCS box containing 1
ZFR zinc finger RNA binding protein
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABLIM3 actin binding LIM protein family, member 3
AHDC1 AT hook, DNA binding motif, containing 1
AP3M2 adaptor-related protein complex 3, mu 2 subunit
ARC activity-regulated cytoskeleton-associated protein
ARMC4 armadillo repeat containing 4
C10ORF88 chromosome 10 open reading frame 88
C14ORF132 chromosome 14 open reading frame 132
C1ORF159 chromosome 1 open reading frame 159
C7ORF43 chromosome 7 open reading frame 43
CAPN5 calpain 5
CD82 CD82 molecule
CDH18 cadherin 18, type 2
CENPC centromere protein C
CHKB choline kinase beta
CSTA cystatin A (stefin A)
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
DGAT1 diacylglycerol O-acyltransferase 1
DGKE diacylglycerol kinase, epsilon 64kDa
F3 coagulation factor III (thromboplastin, tissue factor)
FMO4 flavin containing monooxygenase 4
FOXD1 forkhead box D1
FSD1 fibronectin type III and SPRY domain containing 1
FURIN furin (paired basic amino acid cleaving enzyme)
GAR1 GAR1 ribonucleoprotein
GMEB1 glucocorticoid modulatory element binding protein 1
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPS1 G protein pathway suppressor 1
GTF2I general transcription factor IIi
HOXC8 homeobox C8
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IREB2 iron-responsive element binding protein 2
IRF6 interferon regulatory factor 6
IRF9 interferon regulatory factor 9
KIF13A kinesin family member 13A
KLHL25 kelch-like family member 25
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRP5L low density lipoprotein receptor-related protein 5-like
MAPKBP1 mitogen-activated protein kinase binding protein 1
METTL8 methyltransferase like 8
NAV2 neuron navigator 2
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NPTX1 neuronal pentraxin I
NPY1R neuropeptide Y receptor Y1
NYNRIN NYN domain and retroviral integrase containing
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OVGP1 oviductal glycoprotein 1, 120kDa
PAIP2B poly(A) binding protein interacting protein 2B
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PODNL1 podocan-like 1
PODXL2 podocalyxin-like 2
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTDSS2 phosphatidylserine synthase 2
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RFTN1 raftlin, lipid raft linker 1
RFX7 regulatory factor X, 7
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPL13P5 ribosomal protein L13 pseudogene 5
S100A4 S100 calcium binding protein A4
SCO2 SCO2 cytochrome c oxidase assembly protein
SLC12A9 solute carrier family 12, member 9
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A40 solute carrier family 25, member 40
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPAG7 sperm associated antigen 7
SPIDR scaffolding protein involved in DNA repair
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TCTN2 tectonic family member 2
TESK1 testis-specific kinase 1
TMC5 transmembrane channel-like 5
TMEM254 transmembrane protein 254
TMOD3 tropomodulin 3 (ubiquitous)
TMPRSS3 transmembrane protease, serine 3
TPST2 tyrosylprotein sulfotransferase 2
TRAPPC11 trafficking protein particle complex 11
TRIM32 tripartite motif containing 32
TRIM45 tripartite motif containing 45
TRPM4 transient receptor potential cation channel, subfamily M, member 4
UBE2S ubiquitin-conjugating enzyme E2S
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WLS wntless Wnt ligand secretion mediator
XAB2 XPA binding protein 2
ZMAT5 zinc finger, matrin-type 5
ZNF204P zinc finger protein 204, pseudogene
ZNF211 zinc finger protein 211
ZNF227 zinc finger protein 227
ZNF432 zinc finger protein 432