PHA-00846566E-7046 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the PHA-00846566E-7046 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ADRBK1 adrenergic, beta, receptor kinase 1
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APLP2 amyloid beta (A4) precursor-like protein 2
ATRX alpha thalassemia/mental retardation syndrome X-linked
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BCL2L1 BCL2-like 1
BICD1 bicaudal D homolog 1 (Drosophila)
C7ORF43 chromosome 7 open reading frame 43
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CENPI centromere protein I
CISH cytokine inducible SH2-containing protein
CREB3L1 cAMP responsive element binding protein 3-like 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DOCK10 dedicator of cytokinesis 10
DOHH deoxyhypusine hydroxylase/monooxygenase
DZIP3 DAZ interacting zinc finger protein 3
EIF1 eukaryotic translation initiation factor 1
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM155A family with sequence similarity 155, member A
FBXL15 F-box and leucine-rich repeat protein 15
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FER fer (fps/fes related) tyrosine kinase
FGF2 fibroblast growth factor 2 (basic)
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOXG1 forkhead box G1
FRS3 fibroblast growth factor receptor substrate 3
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA3 GATA binding protein 3
GUK1 guanylate kinase 1
HEATR6 HEAT repeat containing 6
IL20RA interleukin 20 receptor, alpha
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
JUND jun D proto-oncogene
KIAA1644 KIAA1644
KLHL18 kelch-like family member 18
KLHL22 kelch-like family member 22
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP1A microtubule-associated protein 1A
MECP2 methyl CpG binding protein 2
METTL5 methyltransferase like 5
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MSL3 male-specific lethal 3 homolog (Drosophila)
MX1 MX dynamin-like GTPase 1
MXRA8 matrix-remodelling associated 8
NCS1 neuronal calcium sensor 1
NEK3 NIMA-related kinase 3
NOP14-AS1 NOP14 antisense RNA 1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NT5M 5',3'-nucleotidase, mitochondrial
PALM paralemmin
PAOX polyamine oxidase (exo-N4-amino)
PDGFB platelet-derived growth factor beta polypeptide
PGPEP1 pyroglutamyl-peptidase I
PLAGL2 pleiomorphic adenoma gene-like 2
POLG polymerase (DNA directed), gamma
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
REM1 RAS (RAD and GEM)-like GTP-binding 1
REPS1 RALBP1 associated Eps domain containing 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF39 ring finger protein 39
RNGTT RNA guanylyltransferase and 5'-phosphatase
SAMD4A sterile alpha motif domain containing 4A
SCEL sciellin
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIDT2 SID1 transmembrane family, member 2
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMC1A structural maintenance of chromosomes 1A
SMG6 SMG6 nonsense mediated mRNA decay factor
SORBS3 sorbin and SH3 domain containing 3
STK17B serine/threonine kinase 17b
STK4 serine/threonine kinase 4
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TGFA transforming growth factor, alpha
TIMP4 TIMP metallopeptidase inhibitor 4
TLX2 T-cell leukemia homeobox 2
TMEM183A transmembrane protein 183A
TNS1 tensin 1
TUBA3C tubulin, alpha 3c
UBOX5 U-box domain containing 5
UBXN1 UBX domain protein 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZBTB22 zinc finger and BTB domain containing 22
ZNF14 zinc finger protein 14
ZNF197 zinc finger protein 197
ZNF37BP zinc finger protein 37B, pseudogene
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABHD3 abhydrolase domain containing 3
ADAM15 ADAM metallopeptidase domain 15
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BBS7 Bardet-Biedl syndrome 7
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C14ORF93 chromosome 14 open reading frame 93
C4ORF29 chromosome 4 open reading frame 29
CAPN15 calpain 15
CASZ1 castor zinc finger 1
CEP295 centrosomal protein 295kDa
CES3 carboxylesterase 3
CLEC4E C-type lectin domain family 4, member E
CNGB3 cyclic nucleotide gated channel beta 3
CNIH3 cornichon family AMPA receptor auxiliary protein 3
COL9A3 collagen, type IX, alpha 3
CPPED1 calcineurin-like phosphoesterase domain containing 1
CSK c-src tyrosine kinase
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DSCAM Down syndrome cell adhesion molecule
EDIL3 EGF-like repeats and discoidin I-like domains 3
EGR2 early growth response 2
FAM102A family with sequence similarity 102, member A
FAM131B family with sequence similarity 131, member B
FAM188A family with sequence similarity 188, member A
FAM50B family with sequence similarity 50, member B
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCHO1 FCH domain only 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GLCE glucuronic acid epimerase
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIRIP3 HIRA interacting protein 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFLR1 IGF-like family receptor 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL33 interleukin 33
IL7 interleukin 7
IMPAD1 inositol monophosphatase domain containing 1
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LIFR leukemia inhibitory factor receptor alpha
LIPG lipase, endothelial
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MCTP1 multiple C2 domains, transmembrane 1
MCTP2 multiple C2 domains, transmembrane 2
MFSD6 major facilitator superfamily domain containing 6
MRPL28 mitochondrial ribosomal protein L28
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NOL10 nucleolar protein 10
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARD6A par-6 family cell polarity regulator alpha
PER3 period circadian clock 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
PRAME preferentially expressed antigen in melanoma
RAB36 RAB36, member RAS oncogene family
RNF2 ring finger protein 2
RNF43 ring finger protein 43
RRAGB Ras-related GTP binding B
S100A3 S100 calcium binding protein A3
SCD5 stearoyl-CoA desaturase 5
SCGB2A2 secretoglobin, family 2A, member 2
SETD8 SET domain containing (lysine methyltransferase) 8
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SMAD7 SMAD family member 7
SOBP sine oculis binding protein homolog (Drosophila)
SPIDR scaffolding protein involved in DNA repair
SSNA1 Sjogren syndrome nuclear autoantigen 1
STARD3 StAR-related lipid transfer (START) domain containing 3
SYT17 synaptotagmin XVII
SYTL2 synaptotagmin-like 2
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TAOK1 TAO kinase 1
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN12 tetraspanin 12
TUBG2 tubulin, gamma 2
ZFHX2 zinc finger homeobox 2
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF230 zinc finger protein 230
ZNF41 zinc finger protein 41
ZNF426 zinc finger protein 426
ZNF428 zinc finger protein 428
ZNF580 zinc finger protein 580
ZNF639 zinc finger protein 639
ZNHIT2 zinc finger, HIT-type containing 2