PHA-00816795-7076 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the PHA-00816795-7076 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK2 aarF domain containing kinase 2
ADGRL1 adhesion G protein-coupled receptor L1
AHCYL2 adenosylhomocysteinase-like 2
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALG12 ALG12, alpha-1,6-mannosyltransferase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATF6 activating transcription factor 6
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAIAP2 BAI1-associated protein 2
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
CCDC85C coiled-coil domain containing 85C
CCNE1 cyclin E1
CIB2 calcium and integrin binding family member 2
CLCN3 chloride channel, voltage-sensitive 3
COX4I1 cytochrome c oxidase subunit IV isoform 1
CPD carboxypeptidase D
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAL4 dynein, axonemal, light chain 4
DTWD1 DTW domain containing 1
DZIP1 DAZ interacting zinc finger protein 1
ELP6 elongator acetyltransferase complex subunit 6
FAM131B family with sequence similarity 131, member B
FLAD1 flavin adenine dinucleotide synthetase 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GOLIM4 golgi integral membrane protein 4
GPC1 glypican 1
GPER1 G protein-coupled estrogen receptor 1
GRK6 G protein-coupled receptor kinase 6
HDGFRP3 hepatoma-derived growth factor, related protein 3
IFI44L interferon-induced protein 44-like
IFNAR2 interferon (alpha, beta and omega) receptor 2
IGSF3 immunoglobulin superfamily, member 3
IL1RAP interleukin 1 receptor accessory protein
INHBA inhibin, beta A
INPP5K inositol polyphosphate-5-phosphatase K
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KCTD13 potassium channel tetramerization domain containing 13
KDM6B lysine (K)-specific demethylase 6B
KLF4 Kruppel-like factor 4 (gut)
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LPCAT3 lysophosphatidylcholine acyltransferase 3
MAGEA6 melanoma antigen family A6
MARS methionyl-tRNA synthetase
MCMBP minichromosome maintenance complex binding protein
MECP2 methyl CpG binding protein 2
METTL3 methyltransferase like 3
MRPS18A mitochondrial ribosomal protein S18A
MYH10 myosin, heavy chain 10, non-muscle
NARFL nuclear prelamin A recognition factor-like
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFX1 nuclear transcription factor, X-box binding 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGG1 8-oxoguanine DNA glycosylase
ORAI2 ORAI calcium release-activated calcium modulator 2
PACS2 phosphofurin acidic cluster sorting protein 2
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PBX2 pre-B-cell leukemia homeobox 2
PCDH1 protocadherin 1
PCNX pecanex homolog (Drosophila)
PDLIM7 PDZ and LIM domain 7 (enigma)
PEX1 peroxisomal biogenesis factor 1
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PNPLA4 patatin-like phospholipase domain containing 4
PRR7 proline rich 7 (synaptic)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RNF126P1 ring finger protein 126 pseudogene 1
SAFB2 scaffold attachment factor B2
SECISBP2 SECIS binding protein 2
SGSM2 small G protein signaling modulator 2
SHPK sedoheptulokinase
SIK2 salt-inducible kinase 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SSH3 slingshot protein phosphatase 3
SZT2 seizure threshold 2 homolog (mouse)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCTN1 tectonic family member 1
TLE4 transducin-like enhancer of split 4
TM7SF3 transmembrane 7 superfamily member 3
TMEM63A transmembrane protein 63A
TPMT thiopurine S-methyltransferase
TRAK1 trafficking protein, kinesin binding 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TULP4 tubby like protein 4
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
URI1 URI1, prefoldin-like chaperone
USP20 ubiquitin specific peptidase 20
USP27X ubiquitin specific peptidase 27, X-linked
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VWA8 von Willebrand factor A domain containing 8
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZNF671 zinc finger protein 671
ZNF778 zinc finger protein 778
ZNF8 zinc finger protein 8

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ACAD10 acyl-CoA dehydrogenase family, member 10
ADGRG2 adhesion G protein-coupled receptor G2
ALPK1 alpha-kinase 1
ALPK3 alpha-kinase 3
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATXN2 ataxin 2
BBS10 Bardet-Biedl syndrome 10
C11ORF30 chromosome 11 open reading frame 30
CAPN5 calpain 5
CCDC68 coiled-coil domain containing 68
CEP97 centrosomal protein 97kDa
CLIP4 CAP-GLY domain containing linker protein family, member 4
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CNPY3 canopy FGF signaling regulator 3
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CPZ carboxypeptidase Z
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DEPDC1 DEP domain containing 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DLK2 delta-like 2 homolog (Drosophila)
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DTX2 deltex 2, E3 ubiquitin ligase
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
FCHSD2 FCH and double SH3 domains 2
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GJC1 gap junction protein, gamma 1, 45kDa
GLT8D2 glycosyltransferase 8 domain containing 2
GPR1 G protein-coupled receptor 1
GPR137B G protein-coupled receptor 137B
GRAMD4 GRAM domain containing 4
HIST1H2AG histone cluster 1, H2ag
HOOK1 hook microtubule-tethering protein 1
HSPB8 heat shock 22kDa protein 8
IRAK4 interleukin-1 receptor-associated kinase 4
LNPEP leucyl/cystinyl aminopeptidase
LRRC6 leucine rich repeat containing 6
LY6G5C lymphocyte antigen 6 complex, locus G5C
LZTR1 leucine-zipper-like transcription regulator 1
MAGEH1 melanoma antigen family H1
MANBA mannosidase, beta A, lysosomal
MAST3 microtubule associated serine/threonine kinase 3
MBTD1 mbt domain containing 1
MCM9 minichromosome maintenance complex component 9
MFGE8 milk fat globule-EGF factor 8 protein
MMP13 matrix metallopeptidase 13
MOXD1 monooxygenase, DBH-like 1
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NT5C 5', 3'-nucleotidase, cytosolic
ONECUT2 one cut homeobox 2
OSMR oncostatin M receptor
PADI1 peptidyl arginine deiminase, type I
PAQR6 progestin and adipoQ receptor family member VI
PARP3 poly (ADP-ribose) polymerase family, member 3
PBLD phenazine biosynthesis-like protein domain containing
PILRB paired immunoglobin-like type 2 receptor beta
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PORCN porcupine homolog (Drosophila)
POU5F1B POU class 5 homeobox 1B
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRSS16 protease, serine, 16 (thymus)
PTPRU protein tyrosine phosphatase, receptor type, U
RAB23 RAB23, member RAS oncogene family
RAD51D RAD51 paralog D
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RGS17 regulator of G-protein signaling 17
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RUSC2 RUN and SH3 domain containing 2
S100A3 S100 calcium binding protein A3
SAYSD1 SAYSVFN motif domain containing 1
SLC12A8 solute carrier family 12, member 8
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC46A3 solute carrier family 46, member 3
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SSNA1 Sjogren syndrome nuclear autoantigen 1
STK16 serine/threonine kinase 16
TBC1D19 TBC1 domain family, member 19
TCTA T-cell leukemia translocation altered
TM7SF2 transmembrane 7 superfamily member 2
TMEM120B transmembrane protein 120B
TMOD3 tropomodulin 3 (ubiquitous)
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TPST2 tyrosylprotein sulfotransferase 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTF2 transcription termination factor, RNA polymerase II
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USP6 ubiquitin specific peptidase 6
WDR76 WD repeat domain 76
ZBED8 zinc finger, BED-type containing 8
ZDHHC13 zinc finger, DHHC-type containing 13
ZNF273 zinc finger protein 273
ZNF37BP zinc finger protein 37B, pseudogene
ZNF668 zinc finger protein 668