PHA-00767505E-6596 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the PHA-00767505E-6596 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
AKAP12 A kinase (PRKA) anchor protein 12
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AR androgen receptor
ARTN artemin
ATN1 atrophin 1
BCAS1 breast carcinoma amplified sequence 1
BMP7 bone morphogenetic protein 7
CCNF cyclin F
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDYL chromodomain protein, Y-like
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CLCN7 chloride channel, voltage-sensitive 7
CNGB3 cyclic nucleotide gated channel beta 3
CORT cortistatin
DCAF8 DDB1 and CUL4 associated factor 8
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DLG5 discs, large homolog 5 (Drosophila)
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ERCC5 excision repair cross-complementation group 5
FAM118A family with sequence similarity 118, member A
FAM174B family with sequence similarity 174, member B
FER1L4 fer-1-like family member 4, pseudogene (functional)
FOLR1 folate receptor 1 (adult)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GEMIN8 gem (nuclear organelle) associated protein 8
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GOSR2 golgi SNAP receptor complex member 2
GPR107 G protein-coupled receptor 107
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H4D histone cluster 1, H4d
HLA-F major histocompatibility complex, class I, F
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
ING1 inhibitor of growth family, member 1
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IQCE IQ motif containing E
IRAK4 interleukin-1 receptor-associated kinase 4
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JUN jun proto-oncogene
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KHSRP KH-type splicing regulatory protein
KIAA0930 KIAA0930
KLHL25 kelch-like family member 25
LIG3 ligase III, DNA, ATP-dependent
LMNB1 lamin B1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYN LYN proto-oncogene, Src family tyrosine kinase
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP9 microtubule-associated protein 9
MED22 mediator complex subunit 22
MFGE8 milk fat globule-EGF factor 8 protein
MZT2B mitotic spindle organizing protein 2B
NCAPH2 non-SMC condensin II complex, subunit H2
NOP16 NOP16 nucleolar protein
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PKNOX1 PBX/knotted 1 homeobox 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLL polymerase (DNA directed), lambda
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTK6 protein tyrosine kinase 6
QKI QKI, KH domain containing, RNA binding
RAB3A RAB3A, member RAS oncogene family
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS10 regulator of G-protein signaling 10
RIBC2 RIB43A domain with coiled-coils 2
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SATB2 SATB homeobox 2
SEC24A SEC24 family member A
SF3A2 splicing factor 3a, subunit 2, 66kDa
SIRPA signal-regulatory protein alpha
SIRT3 sirtuin 3
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SND1-IT1 SND1 intronic transcript 1
SRRM2 serine/arginine repetitive matrix 2
TADA3 transcriptional adaptor 3
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TDRD3 tudor domain containing 3
TMEM161A transmembrane protein 161A
TMEM45A transmembrane protein 45A
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TUSC3 tumor suppressor candidate 3
UNC93B1 unc-93 homolog B1 (C. elegans)
USP22 ubiquitin specific peptidase 22
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
WDR25 WD repeat domain 25
WDR48 WD repeat domain 48
WNT16 wingless-type MMTV integration site family, member 16
XYLT2 xylosyltransferase II
ZBTB17 zinc finger and BTB domain containing 17
ZNF205 zinc finger protein 205

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABHD17A abhydrolase domain containing 17A
AGMAT agmatine ureohydrolase (agmatinase)
AKIP1 A kinase (PRKA) interacting protein 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATAD5 ATPase family, AAA domain containing 5
BAGE B melanoma antigen
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BST2 bone marrow stromal cell antigen 2
C1QTNF3 C1q and tumor necrosis factor related protein 3
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAPN15 calpain 15
CBX8 chromobox homolog 8
CD53 CD53 molecule
CDC37 cell division cycle 37
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK5 cyclin-dependent kinase 5
CEP85 centrosomal protein 85kDa
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHST10 carbohydrate sulfotransferase 10
CLDND1 claudin domain containing 1
CRISP2 cysteine-rich secretory protein 2
CRLF2 cytokine receptor-like factor 2
CYBA cytochrome b-245, alpha polypeptide
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDA1 DET1 and DDB1 associated 1
DEAF1 DEAF1 transcription factor
DOC2A double C2-like domains, alpha
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENO3 enolase 3 (beta, muscle)
ERN2 endoplasmic reticulum to nucleus signaling 2
EXTL2 exostosin-like glycosyltransferase 2
FKBP10 FK506 binding protein 10, 65 kDa
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GALK1 galactokinase 1
GDAP2 ganglioside induced differentiation associated protein 2
GPHN gephyrin
HIST2H2AA3 histone cluster 2, H2aa3
HMOX1 heme oxygenase 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JUNB jun B proto-oncogene
KIAA0125 KIAA0125
KLF3 Kruppel-like factor 3 (basic)
KLHL12 kelch-like family member 12
LRRC23 leucine rich repeat containing 23
MCAT malonyl CoA:ACP acyltransferase (mitochondrial)
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MMP9 matrix metallopeptidase 9
MOCS3 molybdenum cofactor synthesis 3
MPDU1 mannose-P-dolichol utilization defect 1
MTERF4 mitochondrial transcription termination factor 4
NEK11 NIMA-related kinase 11
NRBP1 nuclear receptor binding protein 1
NRSN2 neurensin 2
ONECUT2 one cut homeobox 2
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PGD phosphogluconate dehydrogenase
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
POGK pogo transposable element with KRAB domain
PRKCD protein kinase C, delta
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
RAB23 RAB23, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNF126P1 ring finger protein 126 pseudogene 1
ROM1 retinal outer segment membrane protein 1
SAYSD1 SAYSVFN motif domain containing 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SETD8 SET domain containing (lysine methyltransferase) 8
SGPP1 sphingosine-1-phosphate phosphatase 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC25A40 solute carrier family 25, member 40
SLMO1 slowmo homolog 1 (Drosophila)
SNX15 sorting nexin 15
TARP TCR gamma alternate reading frame protein
TBC1D17 TBC1 domain family, member 17
TCTN2 tectonic family member 2
TEX40 testis expressed 40
TMEM230 transmembrane protein 230
TMLHE trimethyllysine hydroxylase, epsilon
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VEGFB vascular endothelial growth factor B
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae)
WDR76 WD repeat domain 76
YIPF5 Yip1 domain family, member 5
ZMAT5 zinc finger, matrin-type 5
ZNF141 zinc finger protein 141
ZNF34 zinc finger protein 34
ZNF552 zinc finger protein 552
ZNF74 zinc finger protein 74