PHA-00767505E-6550 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the PHA-00767505E-6550 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
ADAM8 ADAM metallopeptidase domain 8
AKAP7 A kinase (PRKA) anchor protein 7
ANKRD12 ankyrin repeat domain 12
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AR androgen receptor
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
BCL9 B-cell CLL/lymphoma 9
CAPN9 calpain 9
CBX8 chromobox homolog 8
CCDC186 coiled-coil domain containing 186
CDH8 cadherin 8, type 2
CES2 carboxylesterase 2
CGA glycoprotein hormones, alpha polypeptide
CLUAP1 clusterin associated protein 1
COBLL1 cordon-bleu WH2 repeat protein-like 1
CROCC ciliary rootlet coiled-coil, rootletin
DCAF7 DDB1 and CUL4 associated factor 7
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EPN2 epsin 2
ERP44 endoplasmic reticulum protein 44
FBXL15 F-box and leucine-rich repeat protein 15
FBXO46 F-box protein 46
FEM1C fem-1 homolog c (C. elegans)
FERMT1 fermitin family member 1
FH fumarate hydratase
FOXN3 forkhead box N3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GOSR2 golgi SNAP receptor complex member 2
GPER1 G protein-coupled estrogen receptor 1
GRB10 growth factor receptor-bound protein 10
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC10 homeobox C10
HRK harakiri, BCL2 interacting protein
IFITM1 interferon induced transmembrane protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL1R1 interleukin 1 receptor, type I
INPP5K inositol polyphosphate-5-phosphatase K
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KLHL24 kelch-like family member 24
KRAS Kirsten rat sarcoma viral oncogene homolog
KRIT1 KRIT1, ankyrin repeat containing
LAT2 linker for activation of T cells family, member 2
LIN7A lin-7 homolog A (C. elegans)
LMF1 lipase maturation factor 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC15 leucine rich repeat containing 15
LUZP4 leucine zipper protein 4
MAPK14 mitogen-activated protein kinase 14
MC3R melanocortin 3 receptor
MED25 mediator complex subunit 25
MFAP3L microfibrillar-associated protein 3-like
MID1 midline 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOD1 nucleotide-binding oligomerization domain containing 1
NPFFR1 neuropeptide FF receptor 1
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
PACS1 phosphofurin acidic cluster sorting protein 1
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
POFUT1 protein O-fucosyltransferase 1
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PROCR protein C receptor, endothelial
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RECQL5 RecQ protein-like 5
REPS1 RALBP1 associated Eps domain containing 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPL7 ribosomal protein L7
RUSC2 RUN and SH3 domain containing 2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SH3BP2 SH3-domain binding protein 2
SIX2 SIX homeobox 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A40 solute carrier family 25, member 40
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMAD4 SMAD family member 4
SMG5 SMG5 nonsense mediated mRNA decay factor
SMG7 SMG7 nonsense mediated mRNA decay factor
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
TADA3 transcriptional adaptor 3
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
UBOX5 U-box domain containing 5
UFSP2 UFM1-specific peptidase 2
UHRF1BP1L UHRF1 binding protein 1-like
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF292 zinc finger protein 292
ZNF318 zinc finger protein 318
ZNF639 zinc finger protein 639
ZNF783 zinc finger family member 783
ZNF839 zinc finger protein 839

decreased expression

Symbol Name
AIDA axin interactor, dorsalization associated
ALG12 ALG12, alpha-1,6-mannosyltransferase
APOLD1 apolipoprotein L domain containing 1
BIRC7 baculoviral IAP repeat containing 7
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C9ORF40 chromosome 9 open reading frame 40
CAPN15 calpain 15
CCDC121 coiled-coil domain containing 121
CCDC85C coiled-coil domain containing 85C
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CIDEB cell death-inducing DFFA-like effector b
CLDN7 claudin 7
CYBA cytochrome b-245, alpha polypeptide
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DIXDC1 DIX domain containing 1
EDC3 enhancer of mRNA decapping 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
F2R coagulation factor II (thrombin) receptor
FKBP10 FK506 binding protein 10, 65 kDa
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GLS2 glutaminase 2 (liver, mitochondrial)
GMEB1 glucocorticoid modulatory element binding protein 1
H1F0 H1 histone family, member 0
HIST1H1D histone cluster 1, H1d
HP1BP3 heterochromatin protein 1, binding protein 3
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IREB2 iron-responsive element binding protein 2
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LINC00341 long intergenic non-protein coding RNA 341
LRP6 low density lipoprotein receptor-related protein 6
LRRC6 leucine rich repeat containing 6
MAGEF1 melanoma antigen family F1
MAMLD1 mastermind-like domain containing 1
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MPDU1 mannose-P-dolichol utilization defect 1
NPM3 nucleophosmin/nucleoplasmin 3
NPY5R neuropeptide Y receptor Y5
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NT5DC3 5'-nucleotidase domain containing 3
NXF2 nuclear RNA export factor 2
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PADI1 peptidyl arginine deiminase, type I
PARPBP PARP1 binding protein
PDE8B phosphodiesterase 8B
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEAK1 pseudopodium-enriched atypical kinase 1
PGM1 phosphoglucomutase 1
PPAP2C phosphatidic acid phosphatase type 2C
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTPRU protein tyrosine phosphatase, receptor type, U
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB5C RAB5C, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASA2 RAS p21 protein activator 2
RBM41 RNA binding motif protein 41
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF146 ring finger protein 146
RNF170 ring finger protein 170
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF2 ring finger protein 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SH2B3 SH2B adaptor protein 3
SH3GLB2 SH3-domain GRB2-like endophilin B2
SKA1 spindle and kinetochore associated complex subunit 1
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC41A3 solute carrier family 41, member 3
SMG9 SMG9 nonsense mediated mRNA decay factor
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCTA T-cell leukemia translocation altered
TDRD12 tudor domain containing 12
TH tyrosine hydroxylase
TMEM242 transmembrane protein 242
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAIP TRAF interacting protein
TTC26 tetratricopeptide repeat domain 26
TTPAL tocopherol (alpha) transfer protein-like
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
WDR25 WD repeat domain 25
WDR62 WD repeat domain 62
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB38 zinc finger and BTB domain containing 38
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF204P zinc finger protein 204, pseudogene
ZNF205 zinc finger protein 205
ZNF253 zinc finger protein 253