PHA-00767505E-6545 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the PHA-00767505E-6545 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACACA acetyl-CoA carboxylase alpha
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADGRB2 adhesion G protein-coupled receptor B2
ADGRL1 adhesion G protein-coupled receptor L1
AKR1C1 aldo-keto reductase family 1, member C1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AP3B1 adaptor-related protein complex 3, beta 1 subunit
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARTN artemin
ATM ATM serine/threonine kinase
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
C11ORF30 chromosome 11 open reading frame 30
C1QTNF1 C1q and tumor necrosis factor related protein 1
C21ORF2 chromosome 21 open reading frame 2
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CFLAR CASP8 and FADD-like apoptosis regulator
CLSPN claspin
CRYL1 crystallin, lambda 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAF15 DDB1 and CUL4 associated factor 15
DEAF1 DEAF1 transcription factor
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DST dystonin
ECE1 endothelin converting enzyme 1
ECEL1 endothelin converting enzyme-like 1
EDA ectodysplasin A
EDIL3 EGF-like repeats and discoidin I-like domains 3
EPHB2 EPH receptor B2
EPS8L1 EPS8-like 1
ETV1 ets variant 1
FADS2 fatty acid desaturase 2
FAM131B family with sequence similarity 131, member B
FBXW11 F-box and WD repeat domain containing 11
FNDC3A fibronectin type III domain containing 3A
FOXG1 forkhead box G1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABARAPL1 GABA(A) receptor-associated protein like 1
GFER growth factor, augmenter of liver regeneration
HBE1 hemoglobin, epsilon 1
HIPK3 homeodomain interacting protein kinase 3
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
IFT22 intraflagellar transport 22
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM4C lysine (K)-specific demethylase 4C
KIAA0319L KIAA0319-like
KRT6B keratin 6B, type II
LIG3 ligase III, DNA, ATP-dependent
LOC100286895 cell division cycle 27 homolog pseudogene
LPIN1 lipin 1
LPP LIM domain containing preferred translocation partner in lipoma
MAP2K5 mitogen-activated protein kinase kinase 5
MAX MYC associated factor X
MCTP2 multiple C2 domains, transmembrane 2
MUC1 mucin 1, cell surface associated
MXD4 MAX dimerization protein 4
NOP16 NOP16 nucleolar protein
NR4A1 nuclear receptor subfamily 4, group A, member 1
PACS1 phosphofurin acidic cluster sorting protein 1
PCNX pecanex homolog (Drosophila)
PCNXL2 pecanex-like 2 (Drosophila)
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PIAS4 protein inhibitor of activated STAT, 4
PLCG1 phospholipase C, gamma 1
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAB27B RAB27B, member RAS oncogene family
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RHOT2 ras homolog family member T2
RPS28 ribosomal protein S28
RPS3A ribosomal protein S3A
SCAND2P SCAN domain containing 2 pseudogene
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SH2B1 SH2B adaptor protein 1
SLMO1 slowmo homolog 1 (Drosophila)
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SORBS3 sorbin and SH3 domain containing 3
STK11 serine/threonine kinase 11
SUGP1 SURP and G patch domain containing 1
TADA2A transcriptional adaptor 2A
TBC1D2B TBC1 domain family, member 2B
TFIP11 tuftelin interacting protein 11
TMC6 transmembrane channel-like 6
TMEM57 transmembrane protein 57
TTC3 tetratricopeptide repeat domain 3
WWC1 WW and C2 domain containing 1
ZFR zinc finger RNA binding protein
ZNF671 zinc finger protein 671
ZNF702P zinc finger protein 702, pseudogene
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
AFF4 AF4/FMR2 family, member 4
ALPK1 alpha-kinase 1
AMDHD2 amidohydrolase domain containing 2
APOLD1 apolipoprotein L domain containing 1
ARMCX4 armadillo repeat containing, X-linked 4
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BCL7B B-cell CLL/lymphoma 7B
BMP15 bone morphogenetic protein 15
C17ORF70 chromosome 17 open reading frame 70
CCDC85C coiled-coil domain containing 85C
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFAP69 cilia and flagella associated protein 69
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHD3 chromodomain helicase DNA binding protein 3
CLDN14 claudin 14
CLIP4 CAP-GLY domain containing linker protein family, member 4
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CORO2B coronin, actin binding protein, 2B
CORO7 coronin 7
CXORF56 chromosome X open reading frame 56
DDN dendrin
DNAAF2 dynein, axonemal, assembly factor 2
DNM3 dynamin 3
EAF2 ELL associated factor 2
ECM1 extracellular matrix protein 1
EDN1 endothelin 1
ENOX1 ecto-NOX disulfide-thiol exchanger 1
ERCC5 excision repair cross-complementation group 5
FBXO22 F-box protein 22
FOXD1 forkhead box D1
FZD3 frizzled class receptor 3
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNL1 guanine nucleotide binding protein-like 1
HHAT hedgehog acyltransferase
HOMER2 homer scaffolding protein 2
HSPB8 heat shock 22kDa protein 8
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IKZF5 IKAROS family zinc finger 5 (Pegasus)
ISYNA1 inositol-3-phosphate synthase 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KLHL36 kelch-like family member 36
KLK7 kallikrein-related peptidase 7
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRP3 low density lipoprotein receptor-related protein 3
LZTR1 leucine-zipper-like transcription regulator 1
MAGEA5 melanoma antigen family A5
MCC mutated in colorectal cancers
MED9 mediator complex subunit 9
MLYCD malonyl-CoA decarboxylase
MTERF4 mitochondrial transcription termination factor 4
MTG1 mitochondrial ribosome-associated GTPase 1
MXRA8 matrix-remodelling associated 8
MYL5 myosin, light chain 5, regulatory
NACA2 nascent polypeptide-associated complex alpha subunit 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NXPH4 neurexophilin 4
OGFRL1 opioid growth factor receptor-like 1
ONECUT2 one cut homeobox 2
OSMR oncostatin M receptor
OTUD3 OTU deubiquitinase 3
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PALM paralemmin
PARD6A par-6 family cell polarity regulator alpha
PCBP4 poly(rC) binding protein 4
PLEKHA6 pleckstrin homology domain containing, family A member 6
PRDM1 PR domain containing 1, with ZNF domain
PTDSS2 phosphatidylserine synthase 2
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RAB3D RAB3D, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAI2 retinoic acid induced 2
RNF39 ring finger protein 39
RPA4 replication protein A4, 30kDa
RUNDC3B RUN domain containing 3B
SCGB2A2 secretoglobin, family 2A, member 2
SCML2 sex comb on midleg-like 2 (Drosophila)
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC25A40 solute carrier family 25, member 40
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SPIDR scaffolding protein involved in DNA repair
SRD5A3 steroid 5 alpha-reductase 3
SSNA1 Sjogren syndrome nuclear autoantigen 1
SYCP2 synaptonemal complex protein 2
SYNGR3 synaptogyrin 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBC1D19 TBC1 domain family, member 19
TBKBP1 TBK1 binding protein 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMCC2 transmembrane and coiled-coil domain family 2
TMEM183A transmembrane protein 183A
TRIM25 tripartite motif containing 25
VGF VGF nerve growth factor inducible
WDR25 WD repeat domain 25
ZFP30 ZFP30 zinc finger protein
ZNF219 zinc finger protein 219