PHA-00745360-4384 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the PHA-00745360-4384 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP5 A kinase (PRKA) anchor protein 5
AKAP8L A kinase (PRKA) anchor protein 8-like
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
APC adenomatous polyposis coli
ART1 ADP-ribosyltransferase 1
ATG10 autophagy related 10
BAZ2A bromodomain adjacent to zinc finger domain, 2A
CCDC64 coiled-coil domain containing 64
CD47 CD47 molecule
CD58 CD58 molecule
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLCA1 chloride channel accessory 1
CLEC2D C-type lectin domain family 2, member D
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CPEB3 cytoplasmic polyadenylation element binding protein 3
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CYTH4 cytohesin 4
DGCR8 DGCR8 microprocessor complex subunit
EMCN endomucin
EMID1 EMI domain containing 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GABARAPL1 GABA(A) receptor-associated protein like 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GAL3ST4 galactose-3-O-sulfotransferase 4
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GFAP glial fibrillary acidic protein
GK glycerol kinase
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GRK4 G protein-coupled receptor kinase 4
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HFE hemochromatosis
HHAT hedgehog acyltransferase
HIST1H2AB histone cluster 1, H2ab
HNRNPM heterogeneous nuclear ribonucleoprotein M
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
ICOSLG inducible T-cell co-stimulator ligand
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGLJ3 immunoglobulin lambda joining 3
IL12B interleukin 12B
IL18 interleukin 18
INPP5J inositol polyphosphate-5-phosphatase J
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KIAA1109 KIAA1109
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
LOXL2 lysyl oxidase-like 2
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MATN1 matrilin 1, cartilage matrix protein
MC5R melanocortin 5 receptor
MMP11 matrix metallopeptidase 11
MMP25 matrix metallopeptidase 25
MST1 macrophage stimulating 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFIB nuclear factor I/B
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOVA2 neuro-oncological ventral antigen 2
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PLCD1 phospholipase C, delta 1
POM121L2 POM121 transmembrane nucleoporin-like 2
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRSS53 protease, serine, 53
QKI QKI, KH domain containing, RNA binding
RAB3B RAB3B, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
REEP2 receptor accessory protein 2
RHBDL1 rhomboid, veinlet-like 1 (Drosophila)
RRBP1 ribosome binding protein 1
SAMD4A sterile alpha motif domain containing 4A
SECTM1 secreted and transmembrane 1
SERHL2 serine hydrolase-like 2
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STAB2 stabilin 2
SULT4A1 sulfotransferase family 4A, member 1
TACC1 transforming, acidic coiled-coil containing protein 1
TBX3 T-box 3
TCF25 transcription factor 25 (basic helix-loop-helix)
TGM1 transglutaminase 1
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TP53I11 tumor protein p53 inducible protein 11
TTLL7 tubulin tyrosine ligase-like family member 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
XYLB xylulokinase homolog (H. influenzae)
ZNF224 zinc finger protein 224
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACTA1 actin, alpha 1, skeletal muscle
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADGRE3 adhesion G protein-coupled receptor E3
AFF4 AF4/FMR2 family, member 4
AOC2 amine oxidase, copper containing 2 (retina-specific)
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BCL2A1 BCL2-related protein A1
BMP10 bone morphogenetic protein 10
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C3 complement component 3
CD3D CD3d molecule, delta (CD3-TCR complex)
CD70 CD70 molecule
CEL carboxyl ester lipase
CFHR4 complement factor H-related 4
CNTNAP1 contactin associated protein 1
CXCR2 chemokine (C-X-C motif) receptor 2
DDIT3 DNA-damage-inducible transcript 3
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DEPDC5 DEP domain containing 5
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DLK2 delta-like 2 homolog (Drosophila)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EGFL7 EGF-like-domain, multiple 7
ELSPBP1 epididymal sperm binding protein 1
EMP3 epithelial membrane protein 3
FAM76A family with sequence similarity 76, member A
FGF22 fibroblast growth factor 22
FGF23 fibroblast growth factor 23
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GFI1 growth factor independent 1 transcription repressor
GMPR guanosine monophosphate reductase
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR3 G protein-coupled receptor 3
GRPR gastrin-releasing peptide receptor
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H2BJ histone cluster 1, H2bj
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA4 homeobox A4
HOXC5 homeobox C5
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IFNA14 interferon, alpha 14
IL12RB1 interleukin 12 receptor, beta 1
ISL1 ISL LIM homeobox 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA1324 KIAA1324
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF2 Kruppel-like factor 2
KRT31 keratin 31, type I
LARP6 La ribonucleoprotein domain family, member 6
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LMTK2 lemur tyrosine kinase 2
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MEFV Mediterranean fever
MGC2889 uncharacterized protein MGC2889
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MXRA8 matrix-remodelling associated 8
MYO1F myosin IF
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NPPA natriuretic peptide A
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OXCT2 3-oxoacid CoA transferase 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIPOX pipecolic acid oxidase
PRF1 perforin 1 (pore forming protein)
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PSCA prostate stem cell antigen
PTX3 pentraxin 3, long
PWAR5 Prader Willi/Angelman region RNA 5
REM1 RAS (RAD and GEM)-like GTP-binding 1
RHBG Rh family, B glycoprotein (gene/pseudogene)
RPS4Y1 ribosomal protein S4, Y-linked 1
SAMD9 sterile alpha motif domain containing 9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAYSD1 SAYSVFN motif domain containing 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SETD1B SET domain containing 1B
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SSTR5 somatostatin receptor 5
STMN3 stathmin-like 3
TLN1 talin 1
TM4SF5 transmembrane 4 L six family member 5
TMEM209 transmembrane protein 209
TMPRSS4 transmembrane protease, serine 4
USP27X ubiquitin specific peptidase 27, X-linked
USP29 ubiquitin specific peptidase 29
VPS9D1 VPS9 domain containing 1
ZNF112 zinc finger protein 112
ZNF362 zinc finger protein 362
ZNF639 zinc finger protein 639