PHA-00745360-3910 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the PHA-00745360-3910 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABHD8 abhydrolase domain containing 8
ADAP2 ArfGAP with dual PH domains 2
ANGPTL4 angiopoietin-like 4
APAF1 apoptotic peptidase activating factor 1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASIC1 acid sensing (proton gated) ion channel 1
ATN1 atrophin 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BIN1 bridging integrator 1
CAPN10 calpain 10
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCR2 chemokine (C-C motif) receptor 2
CDA cytidine deaminase
CDKN2A cyclin-dependent kinase inhibitor 2A
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CNTNAP1 contactin associated protein 1
COL8A1 collagen, type VIII, alpha 1
COMT catechol-O-methyltransferase
CPNE7 copine VII
CRISP2 cysteine-rich secretory protein 2
CTNNA2 catenin (cadherin-associated protein), alpha 2
CXORF21 chromosome X open reading frame 21
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DIO2 deiodinase, iodothyronine, type II
DMP1 dentin matrix acidic phosphoprotein 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
ERO1LB ERO1-like beta (S. cerevisiae)
FGFBP1 fibroblast growth factor binding protein 1
FGFR1 fibroblast growth factor receptor 1
FLJ11710 uncharacterized protein FLJ11710
GAS7 growth arrest-specific 7
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GIF gastric intrinsic factor (vitamin B synthesis)
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GRM2 glutamate receptor, metabotropic 2
GSK3A glycogen synthase kinase 3 alpha
GUSBP3 glucuronidase, beta pseudogene 3
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ICAM2 intercellular adhesion molecule 2
IFI27 interferon, alpha-inducible protein 27
IL1A interleukin 1, alpha
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCTD12 potassium channel tetramerization domain containing 12
KIF25 kinesin family member 25
L1CAM L1 cell adhesion molecule
LAT2 linker for activation of T cells family, member 2
LDB3 LIM domain binding 3
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LMO4 LIM domain only 4
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MAPK7 mitogen-activated protein kinase 7
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MT1E metallothionein 1E
MTA2 metastasis associated 1 family, member 2
NEU3 sialidase 3 (membrane sialidase)
NF2 neurofibromin 2 (merlin)
NFIB nuclear factor I/B
NOS1 nitric oxide synthase 1 (neuronal)
NOV nephroblastoma overexpressed
NPR3 natriuretic peptide receptor 3
NRG1 neuregulin 1
NXPH4 neurexophilin 4
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PARP3 poly (ADP-ribose) polymerase family, member 3
PARVA parvin, alpha
PCSK2 proprotein convertase subtilisin/kexin type 2
PDLIM5 PDZ and LIM domain 5
PHF1 PHD finger protein 1
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKP2 plakophilin 2
PLIN2 perilipin 2
PRDM12 PR domain containing 12
RBMS2 RNA binding motif, single stranded interacting protein 2
RNF122 ring finger protein 122
RORC RAR-related orphan receptor C
RPL7 ribosomal protein L7
SAYSD1 SAYSVFN motif domain containing 1
SH2D3C SH2 domain containing 3C
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
TCF25 transcription factor 25 (basic helix-loop-helix)
TCF3 transcription factor 3
THSD4 thrombospondin, type I, domain containing 4
TMBIM1 transmembrane BAX inhibitor motif containing 1
TPM2 tropomyosin 2 (beta)
TRIL TLR4 interactor with leucine-rich repeats
TSC2 tuberous sclerosis 2
WAPAL wings apart-like homolog (Drosophila)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ALOX15 arachidonate 15-lipoxygenase
AMPD1 adenosine monophosphate deaminase 1
ANKRD26 ankyrin repeat domain 26
ARMC4 armadillo repeat containing 4
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
BMP3 bone morphogenetic protein 3
BST2 bone marrow stromal cell antigen 2
C5AR1 complement component 5a receptor 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX8 chromobox homolog 8
CCDC71 coiled-coil domain containing 71
CD34 CD34 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD8A CD8a molecule
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CRIP1 cysteine-rich protein 1 (intestinal)
CTIF CBP80/20-dependent translation initiation factor
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DAAM2 dishevelled associated activator of morphogenesis 2
DLL3 delta-like 3 (Drosophila)
ENO3 enolase 3 (beta, muscle)
FAM114A2 family with sequence similarity 114, member A2
GADD45G growth arrest and DNA-damage-inducible, gamma
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GFI1 growth factor independent 1 transcription repressor
GLDC glycine dehydrogenase (decarboxylating)
GPR157 G protein-coupled receptor 157
HHAT hedgehog acyltransferase
HMGB3P1 high mobility group box 3 pseudogene 1
IBSP integrin-binding sialoprotein
INPP5J inositol polyphosphate-5-phosphatase J
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCTD7 potassium channel tetramerization domain containing 7
KIAA0125 KIAA0125
KIAA1107 KIAA1107
KLK8 kallikrein-related peptidase 8
KRT15 keratin 15, type I
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LGALS4 lectin, galactoside-binding, soluble, 4
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LMTK2 lemur tyrosine kinase 2
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAL mal, T-cell differentiation protein
MAP2 microtubule-associated protein 2
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MCOLN3 mucolipin 3
MFGE8 milk fat globule-EGF factor 8 protein
MPG N-methylpurine-DNA glycosylase
MUC3B mucin 3B, cell surface associated
NAT6 N-acetyltransferase 6 (GCN5-related)
NDE1 nudE neurodevelopment protein 1
NKAIN1 Na+/K+ transporting ATPase interacting 1
NXPE3 neurexophilin and PC-esterase domain family, member 3
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PLK3 polo-like kinase 3
PMCH pro-melanin-concentrating hormone
POM121 POM121 transmembrane nucleoporin
POU4F2 POU class 4 homeobox 2
PRSS53 protease, serine, 53
PTPRS protein tyrosine phosphatase, receptor type, S
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARS arginyl-tRNA synthetase
RBM42 RNA binding motif protein 42
RCAN3 RCAN family member 3
RPGRIP1L RPGRIP1-like
RPS14P3 ribosomal protein S14 pseudogene 3
SCGB2A2 secretoglobin, family 2A, member 2
SECTM1 secreted and transmembrane 1
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SETD1B SET domain containing 1B
SIRT4 sirtuin 4
SKAP1 src kinase associated phosphoprotein 1
SLC12A8 solute carrier family 12, member 8
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC25A40 solute carrier family 25, member 40
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMC6 structural maintenance of chromosomes 6
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNRPC small nuclear ribonucleoprotein polypeptide C
SPATA2L spermatogenesis associated 2-like
TBC1D2 TBC1 domain family, member 2
TFDP3 transcription factor Dp family, member 3
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TH tyrosine hydroxylase
THRB thyroid hormone receptor, beta
TMEM40 transmembrane protein 40
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIM36 tripartite motif containing 36
TSC22D4 TSC22 domain family, member 4
WDR33 WD repeat domain 33
WNT16 wingless-type MMTV integration site family, member 16
ZFHX2 zinc finger homeobox 2
ZNF41 zinc finger protein 41
ZSWIM1 zinc finger, SWIM-type containing 1