PHA-00745360-3907 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the PHA-00745360-3907 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADD2 adducin 2 (beta)
ADGRB2 adhesion G protein-coupled receptor B2
ADRA1B adrenoceptor alpha 1B
AK1 adenylate kinase 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ANXA2P1 annexin A2 pseudogene 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CALCR calcitonin receptor
CD79B CD79b molecule, immunoglobulin-associated beta
CDX1 caudal type homeobox 1
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CFLAR CASP8 and FADD-like apoptosis regulator
COL4A6 collagen, type IV, alpha 6
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
DLC1 DLC1 Rho GTPase activating protein
DNASE1L2 deoxyribonuclease I-like 2
DRD2 dopamine receptor D2
ELMO1 engulfment and cell motility 1
ELSPBP1 epididymal sperm binding protein 1
ERO1LB ERO1-like beta (S. cerevisiae)
EXOC6B exocyst complex component 6B
FCMR Fc fragment of IgM receptor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGF6 fibroblast growth factor 6
FSCN3 fascin actin-bundling protein 3, testicular
FXYD2 FXYD domain containing ion transport regulator 2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GDF2 growth differentiation factor 2
GNRH2 gonadotropin-releasing hormone 2
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM4 glutamate receptor, metabotropic 4
HDC histidine decarboxylase
HHIPL2 HHIP-like 2
HIST1H3I histone cluster 1, H3i
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
ICA1 islet cell autoantigen 1, 69kDa
IGFBP5 insulin-like growth factor binding protein 5
IL18 interleukin 18
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
LOXL3 lysyl oxidase-like 3
LRP12 low density lipoprotein receptor-related protein 12
LRRC61 leucine rich repeat containing 61
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAGEA3 melanoma antigen family A3
MAGEB1 melanoma antigen family B1
MAPK7 mitogen-activated protein kinase 7
METTL7A methyltransferase like 7A
MMP11 matrix metallopeptidase 11
MORN1 MORN repeat containing 1
MOS v-mos Moloney murine sarcoma viral oncogene homolog
MTSS1L metastasis suppressor 1-like
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NF2 neurofibromin 2 (merlin)
NNAT neuronatin
NR4A2 nuclear receptor subfamily 4, group A, member 2
NYNRIN NYN domain and retroviral integrase containing
ONECUT2 one cut homeobox 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCDH12 protocadherin 12
PCDHGA3 protocadherin gamma subfamily A, 3
PHF20L1 PHD finger protein 20-like 1
POU4F1 POU class 4 homeobox 1
PPARD peroxisome proliferator-activated receptor delta
PQLC2 PQ loop repeat containing 2
PRLH prolactin releasing hormone
PRM1 protamine 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PXDC1 PX domain containing 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RGS14 regulator of G-protein signaling 14
RND1 Rho family GTPase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERHL2 serine hydrolase-like 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SP100 SP100 nuclear antigen
STOML1 stomatin (EPB72)-like 1
TAPBPL TAP binding protein-like
TCF3 transcription factor 3
TDRD3 tudor domain containing 3
TJAP1 tight junction associated protein 1 (peripheral)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TRD T cell receptor delta locus
UBR4 ubiquitin protein ligase E3 component n-recognin 4
ZDHHC14 zinc finger, DHHC-type containing 14
ZFP64 ZFP64 zinc finger protein
ZNF37BP zinc finger protein 37B, pseudogene
ZNF646 zinc finger protein 646
ZNF682 zinc finger protein 682

decreased expression

Symbol Name
ADTRP androgen-dependent TFPI-regulating protein
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALOX12 arachidonate 12-lipoxygenase
ALPK1 alpha-kinase 1
ANXA2P3 annexin A2 pseudogene 3
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ASAP1-IT1 ASAP1 intronic transcript 1
ASIC3 acid sensing (proton gated) ion channel 3
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCO1 beta-carotene oxygenase 1
C1ORF35 chromosome 1 open reading frame 35
C5ORF45 chromosome 5 open reading frame 45
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC186 coiled-coil domain containing 186
CD83 CD83 molecule
CDK6 cyclin-dependent kinase 6
CEP97 centrosomal protein 97kDa
CLDN1 claudin 1
CNGB3 cyclic nucleotide gated channel beta 3
CTSF cathepsin F
CUZD1 CUB and zona pellucida-like domains 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DGKE diacylglycerol kinase, epsilon 64kDa
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
ELP3 elongator acetyltransferase complex subunit 3
ERCC2 excision repair cross-complementation group 2
EXD3 exonuclease 3'-5' domain containing 3
FAM46C family with sequence similarity 46, member C
FER fer (fps/fes related) tyrosine kinase
FMOD fibromodulin
GAMT guanidinoacetate N-methyltransferase
GLB1L galactosidase, beta 1-like
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HIST1H3E histone cluster 1, H3e
HIST1H4F histone cluster 1, H4f
HOXC10 homeobox C10
HSF2BP heat shock transcription factor 2 binding protein
IQCC IQ motif containing C
IRF7 interferon regulatory factor 7
ITM2C integral membrane protein 2C
KLK8 kallikrein-related peptidase 8
LIG4 ligase IV, DNA, ATP-dependent
LOC729164 hCG1732469
LRRC37A3 leucine rich repeat containing 37, member A3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAOB monoamine oxidase B
MAP2 microtubule-associated protein 2
MFSD6 major facilitator superfamily domain containing 6
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MUC3A mucin 3A, cell surface associated
MUC3B mucin 3B, cell surface associated
NPR3 natriuretic peptide receptor 3
NXPE3 neurexophilin and PC-esterase domain family, member 3
PARG poly (ADP-ribose) glycohydrolase
PCDHB3 protocadherin beta 3
PCDHGA8 protocadherin gamma subfamily A, 8
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHO2 pleckstrin homology domain containing, family O member 2
POM121 POM121 transmembrane nucleoporin
PRSS53 protease, serine, 53
QPCT glutaminyl-peptide cyclotransferase
RAB3A RAB3A, member RAS oncogene family
RNF122 ring finger protein 122
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SENP7 SUMO1/sentrin specific peptidase 7
SH3D21 SH3 domain containing 21
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SOAT2 sterol O-acyltransferase 2
STAB2 stabilin 2
SYNC syncoilin, intermediate filament protein
TBC1D2 TBC1 domain family, member 2
TCP10 t-complex 10
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFF2 trefoil factor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM38B transmembrane protein 38B
TMEM45A transmembrane protein 45A
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPRA1 transmembrane protein, adipocyte asscociated 1
TRIM66 tripartite motif containing 66
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TUBA3C tubulin, alpha 3c
VAX2 ventral anterior homeobox 2
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZFHX2 zinc finger homeobox 2
ZIC3 Zic family member 3
ZNF136 zinc finger protein 136
ZNF34 zinc finger protein 34
ZNF350 zinc finger protein 350
ZNF76 zinc finger protein 76
ZSCAN26 zinc finger and SCAN domain containing 26