PHA-00745360-3827 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the PHA-00745360-3827 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACE2 angiotensin I converting enzyme 2
ACOX3 acyl-CoA oxidase 3, pristanoyl
ACPP acid phosphatase, prostate
AKR1C1 aldo-keto reductase family 1, member C1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANK2 ankyrin 2, neuronal
APAF1 apoptotic peptidase activating factor 1
ATF5 activating transcription factor 5
AXIN1 axin 1
B9D2 B9 protein domain 2
BCL2 B-cell CLL/lymphoma 2
BEST1 bestrophin 1
BRS3 bombesin-like receptor 3
C10ORF10 chromosome 10 open reading frame 10
C11ORF16 chromosome 11 open reading frame 16
C8ORF44 chromosome 8 open reading frame 44
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CALD1 caldesmon 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFAP70 cilia and flagella associated protein 70
CHI3L2 chitinase 3-like 2
CLDN16 claudin 16
CNGB3 cyclic nucleotide gated channel beta 3
CNTN1 contactin 1
CRHR2 corticotropin releasing hormone receptor 2
CRISP2 cysteine-rich secretory protein 2
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DMP1 dentin matrix acidic phosphoprotein 1
DNAAF1 dynein, axonemal, assembly factor 1
DUSP1 dual specificity phosphatase 1
EPS8L1 EPS8-like 1
FAM76A family with sequence similarity 76, member A
FGF16 fibroblast growth factor 16
FLJ11292
FOSL2 FOS-like antigen 2
FXYD2 FXYD domain containing ion transport regulator 2
GAST gastrin
GJD2 gap junction protein, delta 2, 36kDa
GPR15 G protein-coupled receptor 15
GSTA3 glutathione S-transferase alpha 3
GVINP1 GTPase, very large interferon inducible pseudogene 1
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H2BN histone cluster 1, H2bn
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
KIAA1109 KIAA1109
KITLG KIT ligand
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LRRC23 leucine rich repeat containing 23
MBD2 methyl-CpG binding domain protein 2
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MED25 mediator complex subunit 25
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MMP25 matrix metallopeptidase 25
NAV3 neuron navigator 3
NCF4 neutrophil cytosolic factor 4, 40kDa
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
PAX2 paired box 2
PBX2 pre-B-cell leukemia homeobox 2
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PKD2L2 polycystic kidney disease 2-like 2
PML promyelocytic leukemia
POU2F2 POU class 2 homeobox 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRB4 proline-rich protein BstNI subfamily 4
PRKCI protein kinase C, iota
PTAFR platelet-activating factor receptor
PTGDR2 prostaglandin D2 receptor 2
RAB30 RAB30, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RPS14 ribosomal protein S14
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RYR1 ryanodine receptor 1 (skeletal)
SBNO1 strawberry notch homolog 1 (Drosophila)
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SLC17A2 solute carrier family 17, member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SRSF5 serine/arginine-rich splicing factor 5
TAL1 T-cell acute lymphocytic leukemia 1
TBC1D2 TBC1 domain family, member 2
TBC1D22B TBC1 domain family, member 22B
TGFBR1 transforming growth factor, beta receptor 1
TGM4 transglutaminase 4
THPO thrombopoietin
TK2 thymidine kinase 2, mitochondrial
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TRIM10 tripartite motif containing 10
TSKS testis-specific serine kinase substrate
UNC13A unc-13 homolog A (C. elegans)
VWA5A von Willebrand factor A domain containing 5A
WT1-AS WT1 antisense RNA
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
AATK apoptosis-associated tyrosine kinase
ACBD4 acyl-CoA binding domain containing 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKAP5 A kinase (PRKA) anchor protein 5
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ALPK1 alpha-kinase 1
ANGPT4 angiopoietin 4
ANP32A-IT1 ANP32A intronic transcript 1
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
C22ORF29 chromosome 22 open reading frame 29
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
COPZ2 coatomer protein complex, subunit zeta 2
CRELD1 cysteine-rich with EGF-like domains 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DKFZP434C153 DKFZP434C153 protein
DLK2 delta-like 2 homolog (Drosophila)
DMRT1 doublesex and mab-3 related transcription factor 1
DOC2A double C2-like domains, alpha
DPF3 D4, zinc and double PHD fingers, family 3
EFNA3 ephrin-A3
FBXO2 F-box protein 2
FGL1 fibrinogen-like 1
FLCN folliculin
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GLB1L galactosidase, beta 1-like
GPNMB glycoprotein (transmembrane) nmb
GPR157 G protein-coupled receptor 157
GPR21 G protein-coupled receptor 21
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GREB1L growth regulation by estrogen in breast cancer-like
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
HDAC7 histone deacetylase 7
HIST1H2AK histone cluster 1, H2ak
HOXD11 homeobox D11
IL2 interleukin 2
INO80D INO80 complex subunit D
KIFC3 kinesin family member C3
KLHL25 kelch-like family member 25
LAMC3 laminin, gamma 3
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LINC00260 long intergenic non-protein coding RNA 260
LOC390998 ribosomal protein L10 pseudogene
LRP2 low density lipoprotein receptor-related protein 2
LRRC37A3 leucine rich repeat containing 37, member A3
LRRC6 leucine rich repeat containing 6
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYRM9 LYR motif containing 9
MAGEB2 melanoma antigen family B2
MMP13 matrix metallopeptidase 13
MNX1 motor neuron and pancreas homeobox 1
MRPL52 mitochondrial ribosomal protein L52
MVD mevalonate (diphospho) decarboxylase
MYLIP myosin regulatory light chain interacting protein
NHEJ1 nonhomologous end-joining factor 1
NSUN6 NOP2/Sun domain family, member 6
NTSR1 neurotensin receptor 1 (high affinity)
OCA2 oculocutaneous albinism II
OGDHL oxoglutarate dehydrogenase-like
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PENK proenkephalin
PITX2 paired-like homeodomain 2
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRAF2 PRA1 domain family, member 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB40AL RAB40A, member RAS oncogene family-like
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIBC2 RIB43A domain with coiled-coils 2
SAYSD1 SAYSVFN motif domain containing 1
SCNN1B sodium channel, non voltage gated 1 beta subunit
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
STXBP5L syntaxin binding protein 5-like
TMEM74B transmembrane protein 74B
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TOR4A torsin family 4, member A
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TRPV6 transient receptor potential cation channel, subfamily V, member 6
UNC119 unc-119 homolog (C. elegans)
USB1 U6 snRNA biogenesis 1
VLDLR very low density lipoprotein receptor
WNT5B wingless-type MMTV integration site family, member 5B
XDH xanthine dehydrogenase
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF334 zinc finger protein 334
ZNF41 zinc finger protein 41
ZNF446 zinc finger protein 446