PHA-00745360-3824 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the PHA-00745360-3824 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACAN aggrecan
ALDOB aldolase B, fructose-bisphosphate
ARTN artemin
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATN1 atrophin 1
ATP10A ATPase, class V, type 10A
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BMP8B bone morphogenetic protein 8b
BST1 bone marrow stromal cell antigen 1
BTN3A2 butyrophilin, subfamily 3, member A2
C10ORF10 chromosome 10 open reading frame 10
C8ORF44 chromosome 8 open reading frame 44
CADM4 cell adhesion molecule 4
CD300C CD300c molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHI3L2 chitinase 3-like 2
CLCA3P chloride channel accessory 3, pseudogene
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL7A1 collagen, type VII, alpha 1
CORO7 coronin 7
CPB2 carboxypeptidase B2 (plasma)
CRLF1 cytokine receptor-like factor 1
CROCCP3 ciliary rootlet coiled-coil, rootletin pseudogene 3
CRYGC crystallin, gamma C
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DLG4 discs, large homolog 4 (Drosophila)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EFR3B EFR3 homolog B (S. cerevisiae)
FAM76A family with sequence similarity 76, member A
FHL3 four and a half LIM domains 3
FOLR2 folate receptor 2 (fetal)
FOXD2 forkhead box D2
FOXG1 forkhead box G1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GFER growth factor, augmenter of liver regeneration
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
HDAC6 histone deacetylase 6
HFE hemochromatosis
HHLA1 HERV-H LTR-associating 1
HIST1H2AB histone cluster 1, H2ab
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICA1 islet cell autoantigen 1, 69kDa
KANK3 KN motif and ankyrin repeat domains 3
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KITLG KIT ligand
LRRC17 leucine rich repeat containing 17
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MFAP2 microfibrillar-associated protein 2
MST1 macrophage stimulating 1
MUC3B mucin 3B, cell surface associated
MYBPC3 myosin binding protein C, cardiac
MYO15B myosin XVB
MYO1F myosin IF
MYT1 myelin transcription factor 1
NCAPH2 non-SMC condensin II complex, subunit H2
NEURL1 neuralized E3 ubiquitin protein ligase 1
NPY2R neuropeptide Y receptor Y2
PDE5A phosphodiesterase 5A, cGMP-specific
PDLIM4 PDZ and LIM domain 4
PDLIM5 PDZ and LIM domain 5
PGM5 phosphoglucomutase 5
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PLG plasminogen
PML promyelocytic leukemia
POU2F2 POU class 2 homeobox 2
PROX1 prospero homeobox 1
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RGS6 regulator of G-protein signaling 6
RHCE Rh blood group, CcEe antigens
RUNX1 runt-related transcription factor 1
RYR2 ryanodine receptor 2 (cardiac)
SCAPER S-phase cyclin A-associated protein in the ER
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SH3GL3 SH3-domain GRB2-like 3
SIRPA signal-regulatory protein alpha
SLA Src-like-adaptor
SMAD1 SMAD family member 1
SMG7 SMG7 nonsense mediated mRNA decay factor
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNCG synuclein, gamma (breast cancer-specific protein 1)
STK4 serine/threonine kinase 4
TBC1D2 TBC1 domain family, member 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM144 transmembrane protein 144
TMPRSS3 transmembrane protease, serine 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN32 tetraspanin 32
WNT3 wingless-type MMTV integration site family, member 3

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACSS3 acyl-CoA synthetase short-chain family member 3
ALPK3 alpha-kinase 3
ARSB arylsulfatase B
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
BBC3 BCL2 binding component 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L10 BCL2-like 10 (apoptosis facilitator)
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD82 CD82 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CLEC4E C-type lectin domain family 4, member E
COL21A1 collagen, type XXI, alpha 1
COPZ2 coatomer protein complex, subunit zeta 2
CPZ carboxypeptidase Z
CRY2 cryptochrome circadian clock 2
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DDN dendrin
DLK2 delta-like 2 homolog (Drosophila)
DNASE1L3 deoxyribonuclease I-like 3
DOC2A double C2-like domains, alpha
EFNA3 ephrin-A3
EGFL7 EGF-like-domain, multiple 7
ERCC4 excision repair cross-complementation group 4
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FSHB follicle stimulating hormone, beta polypeptide
GAL3ST4 galactose-3-O-sulfotransferase 4
GK3P glycerol kinase 3 pseudogene
GLB1L galactosidase, beta 1-like
GMPR guanosine monophosphate reductase
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR1 G protein-coupled receptor 1
GPR21 G protein-coupled receptor 21
GREB1L growth regulation by estrogen in breast cancer-like
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
HSPA1L heat shock 70kDa protein 1-like
IFNA14 interferon, alpha 14
IFNA17 interferon, alpha 17
IL12A interleukin 12A
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL7 interleukin 7
INF2 inverted formin, FH2 and WH2 domain containing
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF13 Kruppel-like factor 13
KLHL25 kelch-like family member 25
KLHL36 kelch-like family member 36
KRT33A keratin 33A, type I
KRT86 keratin 86, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LOC390998 ribosomal protein L10 pseudogene
LRP2 low density lipoprotein receptor-related protein 2
LRRC2 leucine rich repeat containing 2
LRRK1 leucine-rich repeat kinase 1
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K7CL MAP3K7 C-terminal like
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
MMP3 matrix metallopeptidase 3
MON1B MON1 secretory trafficking family member B
NEUROD1 neuronal differentiation 1
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NT5M 5',3'-nucleotidase, mitochondrial
NTNG1 netrin G1
OLFML2A olfactomedin-like 2A
OLFML2B olfactomedin-like 2B
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAQR5 progestin and adipoQ receptor family member V
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIP prolactin-induced protein
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRAF2 PRA1 domain family, member 2
PRAMEF11 PRAME family member 11
PRR14L proline rich 14-like
RAB36 RAB36, member RAS oncogene family
RAB40AL RAB40A, member RAS oncogene family-like
S1PR1 sphingosine-1-phosphate receptor 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SENP7 SUMO1/sentrin specific peptidase 7
SLCO5A1 solute carrier organic anion transporter family, member 5A1
ST7L suppression of tumorigenicity 7 like
TH tyrosine hydroxylase
THRB thyroid hormone receptor, beta
TIGD6 tigger transposable element derived 6
TMEM74B transmembrane protein 74B
TRAC T cell receptor alpha constant
TSC22D4 TSC22 domain family, member 4
ZNF155 zinc finger protein 155
ZNF219 zinc finger protein 219
ZNF446 zinc finger protein 446
ZNF749 zinc finger protein 749
ZXDB zinc finger, X-linked, duplicated B