PHA-00665752-6578 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the PHA-00665752-6578 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APLP1 amyloid beta (A4) precursor-like protein 1
ARFRP1 ADP-ribosylation factor related protein 1
ARHGAP4 Rho GTPase activating protein 4
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATG12 autophagy related 12
ATG4B autophagy related 4B, cysteine peptidase
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAHCC1 BAH domain and coiled-coil containing 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C14ORF79 chromosome 14 open reading frame 79
C21ORF2 chromosome 21 open reading frame 2
C7ORF43 chromosome 7 open reading frame 43
CA12 carbonic anhydrase XII
CA4 carbonic anhydrase IV
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CD302 CD302 molecule
CD52 CD52 molecule
CDK10 cyclin-dependent kinase 10
CDK12 cyclin-dependent kinase 12
CES2 carboxylesterase 2
CLCN7 chloride channel, voltage-sensitive 7
COL5A1 collagen, type V, alpha 1
CORO1A coronin, actin binding protein, 1A
CORT cortistatin
CTSF cathepsin F
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHRS2 dehydrogenase/reductase (SDR family) member 2
ELOVL4 ELOVL fatty acid elongase 4
EML2 echinoderm microtubule associated protein like 2
FAM149B1 family with sequence similarity 149, member B1
FBXL2 F-box and leucine-rich repeat protein 2
FBXO2 F-box protein 2
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
HDAC7 histone deacetylase 7
HDLBP high density lipoprotein binding protein
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICOSLG inducible T-cell co-stimulator ligand
INSIG1 insulin induced gene 1
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
LAMP1 lysosomal-associated membrane protein 1
LOC644450 uncharacterized LOC644450
LRRC40 leucine rich repeat containing 40
LY6D lymphocyte antigen 6 complex, locus D
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MBD3 methyl-CpG binding domain protein 3
MSL3 male-specific lethal 3 homolog (Drosophila)
MUC3B mucin 3B, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXD4 MAX dimerization protein 4
NDE1 nudE neurodevelopment protein 1
NPR2 natriuretic peptide receptor 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PAQR6 progestin and adipoQ receptor family member VI
PCDH1 protocadherin 1
PCDH9 protocadherin 9
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIDD1 p53-induced death domain protein 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTDSS2 phosphatidylserine synthase 2
PTRF polymerase I and transcript release factor
RGS10 regulator of G-protein signaling 10
RNF43 ring finger protein 43
SAPCD1 suppressor APC domain containing 1
SF3A2 splicing factor 3a, subunit 2, 66kDa
SFT2D2 SFT2 domain containing 2
SH2D3A SH2 domain containing 3A
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
ST5 suppression of tumorigenicity 5
SUGP1 SURP and G patch domain containing 1
TAZ tafazzin
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNS2 tensin 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTBK2 tau tubulin kinase 2
TTC38 tetratricopeptide repeat domain 38
UNC45A unc-45 homolog A (C. elegans)
WDR4 WD repeat domain 4
WDTC1 WD and tetratricopeptide repeats 1
ZBTB22 zinc finger and BTB domain containing 22
ZNF205 zinc finger protein 205
ZNF609 zinc finger protein 609
ZNF701 zinc finger protein 701
ZNF76 zinc finger protein 76
ZNF783 zinc finger family member 783
ZNF8 zinc finger protein 8

decreased expression

Symbol Name
AKTIP AKT interacting protein
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ATAD2 ATPase family, AAA domain containing 2
ATG7 autophagy related 7
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BCAS4 breast carcinoma amplified sequence 4
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BSG basigin (Ok blood group)
C21ORF91 chromosome 21 open reading frame 91
CDC37 cell division cycle 37
CENPJ centromere protein J
CHST10 carbohydrate sulfotransferase 10
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLCN2 chloride channel, voltage-sensitive 2
COMMD10 COMM domain containing 10
CRIP2 cysteine-rich protein 2
CTSD cathepsin D
CYB5R4 cytochrome b5 reductase 4
DAP death-associated protein
DARS2 aspartyl-tRNA synthetase 2, mitochondrial
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DCLRE1A DNA cross-link repair 1A
DOCK1 dedicator of cytokinesis 1
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
DUSP9 dual specificity phosphatase 9
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENO2 enolase 2 (gamma, neuronal)
ERCC8 excision repair cross-complementation group 8
ERO1L ERO1-like (S. cerevisiae)
EXOSC5 exosome component 5
FGL1 fibrinogen-like 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GDAP1 ganglioside induced differentiation associated protein 1
GDE1 glycerophosphodiester phosphodiesterase 1
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HIST1H2AK histone cluster 1, H2ak
HNRNPF heterogeneous nuclear ribonucleoprotein F
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IREB2 iron-responsive element binding protein 2
KDM5C lysine (K)-specific demethylase 5C
KLHDC3 kelch domain containing 3
METTL8 methyltransferase like 8
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MLF2 myeloid leukemia factor 2
MPDU1 mannose-P-dolichol utilization defect 1
MSH2 mutS homolog 2
NBEAL2 neurobeachin-like 2
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NMD3 NMD3 ribosome export adaptor
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OCLN occludin
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PARPBP PARP1 binding protein
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCBP1 poly(rC) binding protein 1
PGD phosphogluconate dehydrogenase
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
POGK pogo transposable element with KRAB domain
POLL polymerase (DNA directed), lambda
PROS1 protein S (alpha)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTER phosphotriesterase related
QTRT1 queuine tRNA-ribosyltransferase 1
RGS2 regulator of G-protein signaling 2
RHOC ras homolog family member C
RNF39 ring finger protein 39
RPP14 ribonuclease P/MRP 14kDa subunit
RWDD2A RWD domain containing 2A
SCYL2 SCY1-like 2 (S. cerevisiae)
SELT selenoprotein T
SGPP1 sphingosine-1-phosphate phosphatase 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SIDT1 SID1 transmembrane family, member 1
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SNORA21 small nucleolar RNA, H/ACA box 21
SNX5 sorting nexin 5
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TMEM230 transmembrane protein 230
TMEM254 transmembrane protein 254
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
UBE2M ubiquitin-conjugating enzyme E2M
UROS uroporphyrinogen III synthase
USP21 ubiquitin specific peptidase 21
VEGFB vascular endothelial growth factor B
WDR76 WD repeat domain 76
YIPF5 Yip1 domain family, member 5
ZFYVE21 zinc finger, FYVE domain containing 21
ZNF141 zinc finger protein 141
ZNF510 zinc finger protein 510
ZW10 zw10 kinetochore protein