PF-01378883-00-6405 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the PF-01378883-00-6405 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADAM22 ADAM metallopeptidase domain 22
ADCY2 adenylate cyclase 2 (brain)
AEBP1 AE binding protein 1
AK1 adenylate kinase 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
AMPD1 adenosine monophosphate deaminase 1
APOE apolipoprotein E
ARHGAP24 Rho GTPase activating protein 24
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BCL3 B-cell CLL/lymphoma 3
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BTN3A3 butyrophilin, subfamily 3, member A3
C19ORF66 chromosome 19 open reading frame 66
C1RL complement component 1, r subcomponent-like
CAMK1 calcium/calmodulin-dependent protein kinase I
CD69 CD69 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK6 cyclin-dependent kinase 6
CHM choroideremia (Rab escort protein 1)
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CNGB3 cyclic nucleotide gated channel beta 3
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DOCK5 dedicator of cytokinesis 5
DOCK9 dedicator of cytokinesis 9
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DSC3 desmocollin 3
DUSP6 dual specificity phosphatase 6
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ETV5 ets variant 5
FBXL7 F-box and leucine-rich repeat protein 7
FHL1 four and a half LIM domains 1
FPR1 formyl peptide receptor 1
FSHB follicle stimulating hormone, beta polypeptide
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GBP1 guanylate binding protein 1, interferon-inducible
GOSR2 golgi SNAP receptor complex member 2
GPC3 glypican 3
HIST1H4E histone cluster 1, H4e
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HRH3 histamine receptor H3
ICAM1 intercellular adhesion molecule 1
IFI6 interferon, alpha-inducible protein 6
IFNG interferon, gamma
IRF4 interferon regulatory factor 4
ITGB4 integrin, beta 4
KIAA1467 KIAA1467
LEFTY2 left-right determination factor 2
LMNA lamin A/C
LRP12 low density lipoprotein receptor-related protein 12
LRRC17 leucine rich repeat containing 17
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP2 microtubule-associated protein 2
MFAP3L microfibrillar-associated protein 3-like
MFSD7 major facilitator superfamily domain containing 7
MMP11 matrix metallopeptidase 11
MSI1 musashi RNA-binding protein 1
NME8 NME/NM23 family member 8
NR6A1 nuclear receptor subfamily 6, group A, member 1
NRP2 neuropilin 2
NTF3 neurotrophin 3
P3H2 prolyl 3-hydroxylase 2
PADI3 peptidyl arginine deiminase, type III
PCDHB3 protocadherin beta 3
PHTF2 putative homeodomain transcription factor 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLIN2 perilipin 2
PLTP phospholipid transfer protein
PQLC3 PQ loop repeat containing 3
PSG9 pregnancy specific beta-1-glycoprotein 9
PTK2B protein tyrosine kinase 2 beta
RBM12B RNA binding motif protein 12B
RBM48 RNA binding motif protein 48
RFXAP regulatory factor X-associated protein
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SMOX spermine oxidase
SPEG SPEG complex locus
SPON1 spondin 1, extracellular matrix protein
SPRY4 sprouty homolog 4 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSC22D2 TSC22 domain family, member 2
TTC38 tetratricopeptide repeat domain 38
UBR2 ubiquitin protein ligase E3 component n-recognin 2
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR78 WD repeat domain 78
WNT16 wingless-type MMTV integration site family, member 16
YTHDC2 YTH domain containing 2
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALOX12 arachidonate 12-lipoxygenase
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASIC3 acid sensing (proton gated) ion channel 3
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
BCAS1 breast carcinoma amplified sequence 1
BCL2A1 BCL2-related protein A1
BCO1 beta-carotene oxygenase 1
BMP15 bone morphogenetic protein 15
C19ORF73 chromosome 19 open reading frame 73
C5ORF42 chromosome 5 open reading frame 42
CACNG3 calcium channel, voltage-dependent, gamma subunit 3
CCL19 chemokine (C-C motif) ligand 19
CD79B CD79b molecule, immunoglobulin-associated beta
CDK3 cyclin-dependent kinase 3
CDO1 cysteine dioxygenase type 1
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CGREF1 cell growth regulator with EF-hand domain 1
CLCA3P chloride channel accessory 3, pseudogene
CLCN6 chloride channel, voltage-sensitive 6
CLSTN3 calsyntenin 3
CNTD2 cyclin N-terminal domain containing 2
COL15A1 collagen, type XV, alpha 1
CPA2 carboxypeptidase A2 (pancreatic)
DAGLA diacylglycerol lipase, alpha
DLK1 delta-like 1 homolog (Drosophila)
DMRT1 doublesex and mab-3 related transcription factor 1
DSPP dentin sialophosphoprotein
DTX2 deltex 2, E3 ubiquitin ligase
ERCC2 excision repair cross-complementation group 2
ERN1 endoplasmic reticulum to nucleus signaling 1
FAM198B family with sequence similarity 198, member B
FAM212B family with sequence similarity 212, member B
FBXO2 F-box protein 2
FGF4 fibroblast growth factor 4
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GARNL3 GTPase activating Rap/RanGAP domain-like 3
GOLGA6A golgin A6 family, member A
GPR15 G protein-coupled receptor 15
GRTP1 growth hormone regulated TBC protein 1
HIST1H3I histone cluster 1, H3i
HIST1H4F histone cluster 1, H4f
HLA-DMB major histocompatibility complex, class II, DM beta
HOXA4 homeobox A4
HOXC5 homeobox C5
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IL36RN interleukin 36 receptor antagonist
IQCC IQ motif containing C
ITGA8 integrin, alpha 8
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA0125 KIAA0125
KLF2 Kruppel-like factor 2
LHX1 LIM homeobox 1
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
MFSD6 major facilitator superfamily domain containing 6
MIP major intrinsic protein of lens fiber
MLN motilin
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MPP1 membrane protein, palmitoylated 1, 55kDa
NCF1C neutrophil cytosolic factor 1C pseudogene
NEUROD4 neuronal differentiation 4
NPPA natriuretic peptide A
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
PARP3 poly (ADP-ribose) polymerase family, member 3
PCDHGA8 protocadherin gamma subfamily A, 8
PENK proenkephalin
PEX5L peroxisomal biogenesis factor 5-like
PHEX phosphate regulating endopeptidase homolog, X-linked
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POF1B premature ovarian failure, 1B
POM121L2 POM121 transmembrane nucleoporin-like 2
PRLH prolactin releasing hormone
PRO2964 uncharacterized protein PRO2964
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PURG purine-rich element binding protein G
QPCT glutaminyl-peptide cyclotransferase
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RDH16 retinol dehydrogenase 16 (all-trans)
SDC3 syndecan 3
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
STAC SH3 and cysteine rich domain
SULT4A1 sulfotransferase family 4A, member 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TLR5 toll-like receptor 5
TMC5 transmembrane channel-like 5
TMEM206 transmembrane protein 206
TMLHE trimethyllysine hydroxylase, epsilon
TRIM36 tripartite motif containing 36
TSGA10 testis specific, 10
TUBB2B tubulin, beta 2B class IIb
ZNF155 zinc finger protein 155