PF-01378883-00-6363 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the PF-01378883-00-6363 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
AK1 adenylate kinase 1
AMPD1 adenosine monophosphate deaminase 1
AMPD3 adenosine monophosphate deaminase 3
APC adenomatous polyposis coli
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARHGAP24 Rho GTPase activating protein 24
BGN biglycan
C1ORF61 chromosome 1 open reading frame 61
C2 complement component 2
CA5B carbonic anhydrase VB, mitochondrial
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC85B coiled-coil domain containing 85B
CCL19 chemokine (C-C motif) ligand 19
CDA cytidine deaminase
CDC5L cell division cycle 5-like
CHML choroideremia-like (Rab escort protein 2)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLTC clathrin, heavy chain (Hc)
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNTNAP2 contactin associated protein-like 2
CRYAA crystallin, alpha A
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTGF connective tissue growth factor
DRD2 dopamine receptor D2
DUSP6 dual specificity phosphatase 6
EIF3F eukaryotic translation initiation factor 3, subunit F
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETV5 ets variant 5
EXPH5 exophilin 5
FAM120C family with sequence similarity 120C
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRMD1 FERM domain containing 1
FRMD8 FERM domain containing 8
GLDC glycine dehydrogenase (decarboxylating)
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GPX2 glutathione peroxidase 2
GUCA1A guanylate cyclase activator 1A (retina)
HMG20B high mobility group 20B
HOXA10 homeobox A10
HOXA11 homeobox A11
HYAL1 hyaluronoglucosaminidase 1
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
IGFBP3 insulin-like growth factor binding protein 3
IRF4 interferon regulatory factor 4
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIAA0226L KIAA0226-like
KL klotho
KRT16 keratin 16, type I
LAT2 linker for activation of T cells family, member 2
LPA lipoprotein, Lp(a)
LRRC48 leucine rich repeat containing 48
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MORN1 MORN repeat containing 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NCR2 natural cytotoxicity triggering receptor 2
NME5 NME/NM23 family member 5
NPY2R neuropeptide Y receptor Y2
NR6A1 nuclear receptor subfamily 6, group A, member 1
NXPH3 neurexophilin 3
PDLIM5 PDZ and LIM domain 5
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLAU plasminogen activator, urokinase
PNPLA3 patatin-like phospholipase domain containing 3
PSD3 pleckstrin and Sec7 domain containing 3
PTAFR platelet-activating factor receptor
PTCH1 patched 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRM protein tyrosine phosphatase, receptor type, M
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RASAL2 RAS protein activator like 2
RELN reelin
RIMS3 regulating synaptic membrane exocytosis 3
SAFB scaffold attachment factor B
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFTPC surfactant protein C
SH2D2A SH2 domain containing 2A
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNTA1 syntrophin, alpha 1
SNTG1 syntrophin, gamma 1
SPRY4 sprouty homolog 4 (Drosophila)
STAB2 stabilin 2
STK24 serine/threonine kinase 24
SUGP1 SURP and G patch domain containing 1
SULT4A1 sulfotransferase family 4A, member 1
SYT5 synaptotagmin V
TBX10 T-box 10
TENM4 teneurin transmembrane protein 4
TIMP3 TIMP metallopeptidase inhibitor 3
TK2 thymidine kinase 2, mitochondrial
TLR2 toll-like receptor 2
TRIP6 thyroid hormone receptor interactor 6
UNC5B unc-5 homolog B (C. elegans)
ZNF646 zinc finger protein 646

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ACTL8 actin-like 8
AIRE autoimmune regulator
AQP7 aquaporin 7
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ATG10 autophagy related 10
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BANK1 B-cell scaffold protein with ankyrin repeats 1
BEST2 bestrophin 2
BMP15 bone morphogenetic protein 15
BTNL2 butyrophilin-like 2
C11ORF16 chromosome 11 open reading frame 16
C5AR1 complement component 5a receptor 1
CA5BP1 carbonic anhydrase VB pseudogene 1
CAPN5 calpain 5
CCDC181 coiled-coil domain containing 181
CCDC71 coiled-coil domain containing 71
CCRL2 chemokine (C-C motif) receptor-like 2
CD244 CD244 molecule, natural killer cell receptor 2B4
CD82 CD82 molecule
CD8A CD8a molecule
CES3 carboxylesterase 3
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
COL9A1 collagen, type IX, alpha 1
CRISP2 cysteine-rich secretory protein 2
CRYGD crystallin, gamma D
CRYM crystallin, mu
CT55 cancer/testis antigen 55
CUBN cubilin (intrinsic factor-cobalamin receptor)
DOK5 docking protein 5
EPHB6 EPH receptor B6
ETNPPL ethanolamine-phosphate phospho-lyase
EXTL1 exostosin-like glycosyltransferase 1
F2RL3 coagulation factor II (thrombin) receptor-like 3
F9 coagulation factor IX
FGL1 fibrinogen-like 1
FLJ21369 uncharacterized protein FLJ21369
FMOD fibromodulin
FOXJ1 forkhead box J1
FZD9 frizzled class receptor 9
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPR183 G protein-coupled receptor 183
GRM4 glutamate receptor, metabotropic 4
HIST1H2BB histone cluster 1, H2bb
HOXB9 homeobox B9
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
ICOS inducible T-cell co-stimulator
IDI2-AS1 IDI2 antisense RNA 1
IL11RA interleukin 11 receptor, alpha
IRS4 insulin receptor substrate 4
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KLK11 kallikrein-related peptidase 11
KLK12 kallikrein-related peptidase 12
KRT24 keratin 24, type I
LIM2 lens intrinsic membrane protein 2, 19kDa
LOC284244 uncharacterized LOC284244
LRRC6 leucine rich repeat containing 6
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MLLT4-AS1 MLLT4 antisense RNA 1 (head to head)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MYOZ3 myozenin 3
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NEUROD2 neuronal differentiation 2
NOX3 NADPH oxidase 3
NPPA natriuretic peptide A
NRDE2 NRDE-2, necessary for RNA interference, domain containing
NTN3 netrin 3
NXF2 nuclear RNA export factor 2
NXPE3 neurexophilin and PC-esterase domain family, member 3
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PAX1 paired box 1
PHEX phosphate regulating endopeptidase homolog, X-linked
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
POPDC3 popeye domain containing 3
POU5F1B POU class 5 homeobox 1B
PROX1 prospero homeobox 1
PSG4 pregnancy specific beta-1-glycoprotein 4
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RIC3 RIC3 acetylcholine receptor chaperone
RPS2P45 ribosomal protein S2 pseudogene 45
S100A9 S100 calcium binding protein A9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEMG2 semenogelin II
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
STMN4 stathmin-like 4
SYNDIG1 synapse differentiation inducing 1
T T, brachyury homolog (mouse)
TM4SF5 transmembrane 4 L six family member 5
TMEM8B transmembrane protein 8B
TMPRSS4 transmembrane protease, serine 4
TRIM58 tripartite motif containing 58
TSPAN2 tetraspanin 2
TULP2 tubby like protein 2
ZBTB7B zinc finger and BTB domain containing 7B
ZNF197 zinc finger protein 197
ZSWIM1 zinc finger, SWIM-type containing 1