PF-00562151-00-6907 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the PF-00562151-00-6907 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
AKR1C1 aldo-keto reductase family 1, member C1
AMBRA1 autophagy/beclin-1 regulator 1
ARHGAP24 Rho GTPase activating protein 24
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
AUH AU RNA binding protein/enoyl-CoA hydratase
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BTN3A2 butyrophilin, subfamily 3, member A2
C16ORF45 chromosome 16 open reading frame 45
CBX4 chromobox homolog 4
CCDC68 coiled-coil domain containing 68
CCDC88C coiled-coil domain containing 88C
CCNJ cyclin J
CDH13 cadherin 13
CDYL chromodomain protein, Y-like
CHN2 chimerin 2
COL4A1 collagen, type IV, alpha 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5R4 cytochrome b5 reductase 4
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYTH3 cytohesin 3
DCLRE1A DNA cross-link repair 1A
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DNM2 dynamin 2
EXOC7 exocyst complex component 7
FAM222B family with sequence similarity 222, member B
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAN gigaxonin
GLRA2 glycine receptor, alpha 2
GLRB glycine receptor, beta
GON4L gon-4-like (C. elegans)
GRSF1 G-rich RNA sequence binding factor 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H3G histone cluster 1, H3g
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOXA2 homeobox A2
HSPA4L heat shock 70kDa protein 4-like
IL1RAP interleukin 1 receptor accessory protein
IRS2 insulin receptor substrate 2
KIAA0319L KIAA0319-like
KLF4 Kruppel-like factor 4 (gut)
KRT86 keratin 86, type II
LARP4B La ribonucleoprotein domain family, member 4B
LIG4 ligase IV, DNA, ATP-dependent
LIMK2 LIM domain kinase 2
LRRC8B leucine rich repeat containing 8 family, member B
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYPD3 LY6/PLAUR domain containing 3
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAGOH2P mago-nashi homolog 2, pseudogene
METTL5 methyltransferase like 5
MGP matrix Gla protein
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MTM1 myotubularin 1
MTMR2 myotubularin related protein 2
MTRF1 mitochondrial translational release factor 1
NCK1 NCK adaptor protein 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NKIRAS2 NFKB inhibitor interacting Ras-like 2
NLE1 notchless homolog 1 (Drosophila)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP160 nucleoporin 160kDa
NUP205 nucleoporin 205kDa
PACS1 phosphofurin acidic cluster sorting protein 1
PARM1 prostate androgen-regulated mucin-like protein 1
PDE10A phosphodiesterase 10A
PDE4DIP phosphodiesterase 4D interacting protein
PEX1 peroxisomal biogenesis factor 1
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLSCR4 phospholipid scramblase 4
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RGS20 regulator of G-protein signaling 20
RHOBTB1 Rho-related BTB domain containing 1
SECISBP2 SECIS binding protein 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SETBP1 SET binding protein 1
SKA1 spindle and kinetochore associated complex subunit 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG5 SMG5 nonsense mediated mRNA decay factor
SMIM8 small integral membrane protein 8
SOCS2 suppressor of cytokine signaling 2
SSBP2 single-stranded DNA binding protein 2
STMN1 stathmin 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TFCP2 transcription factor CP2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM242 transmembrane protein 242
TNS2 tensin 2
TTLL4 tubulin tyrosine ligase-like family member 4
VEZT vezatin, adherens junctions transmembrane protein
WNT10B wingless-type MMTV integration site family, member 10B
ZMYND8 zinc finger, MYND-type containing 8
ZNF318 zinc finger protein 318
ZNF552 zinc finger protein 552

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTG2 actin, gamma 2, smooth muscle, enteric
ALS2CL ALS2 C-terminal like
ANKRD40 ankyrin repeat domain 40
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BGLAP bone gamma-carboxyglutamate (gla) protein
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C17ORF53 chromosome 17 open reading frame 53
CA5BP1 carbonic anhydrase VB pseudogene 1
CCNO cyclin O
CD3D CD3d molecule, delta (CD3-TCR complex)
CD70 CD70 molecule
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHPF chondroitin polymerizing factor
CIDEC cell death-inducing DFFA-like effector c
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CPA4 carboxypeptidase A4
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DPF1 D4, zinc and double PHD fingers family 1
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ERCC2 excision repair cross-complementation group 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FER fer (fps/fes related) tyrosine kinase
GPC3 glypican 3
GPR137B G protein-coupled receptor 137B
GPS2 G protein pathway suppressor 2
GPX2 glutathione peroxidase 2
HDAC7 histone deacetylase 7
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSF2BP heat shock transcription factor 2 binding protein
IL7R interleukin 7 receptor
INHA inhibin, alpha
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KPTN kaptin (actin binding protein)
LNPEP leucyl/cystinyl aminopeptidase
LOXL1 lysyl oxidase-like 1
MAL mal, T-cell differentiation protein
MOXD1 monooxygenase, DBH-like 1
MPDU1 mannose-P-dolichol utilization defect 1
MPI mannose phosphate isomerase
MTA2 metastasis associated 1 family, member 2
MYL5 myosin, light chain 5, regulatory
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
OLFML2B olfactomedin-like 2B
ORC1 origin recognition complex, subunit 1
PC pyruvate carboxylase
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PECR peroxisomal trans-2-enoyl-CoA reductase
PGPEP1 pyroglutamyl-peptidase I
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAG1 pleiomorphic adenoma gene 1
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PTGES2 prostaglandin E synthase 2
RAB4B RAB4B, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM42 RNA binding motif protein 42
RHBDD3 rhomboid domain containing 3
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SPIDR scaffolding protein involved in DNA repair
SPX spexin hormone
SYTL2 synaptotagmin-like 2
TBC1D17 TBC1 domain family, member 17
TK1 thymidine kinase 1, soluble
TMC7 transmembrane channel-like 7
TMEM115 transmembrane protein 115
TMEM132A transmembrane protein 132A
TMEM140 transmembrane protein 140
TMEM206 transmembrane protein 206
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TOLLIP toll interacting protein
TRABD TraB domain containing
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUBA3D tubulin, alpha 3d
TXLNG taxilin gamma
URM1 ubiquitin related modifier 1
UROS uroporphyrinogen III synthase
USP20 ubiquitin specific peptidase 20
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WDR18 WD repeat domain 18
WDR62 WD repeat domain 62
ZC3H12A zinc finger CCCH-type containing 12A
ZMAT5 zinc finger, matrin-type 5
ZNF215 zinc finger protein 215
ZNF446 zinc finger protein 446
ZNF668 zinc finger protein 668