PF-00562151-00-6868 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the PF-00562151-00-6868 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADCY1 adenylate cyclase 1 (brain)
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ALPK1 alpha-kinase 1
AMH anti-Mullerian hormone
ATF6B activating transcription factor 6 beta
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C14ORF132 chromosome 14 open reading frame 132
C1ORF54 chromosome 1 open reading frame 54
C22ORF46 chromosome 22 open reading frame 46
CA4 carbonic anhydrase IV
CA9 carbonic anhydrase IX
CAMKMT calmodulin-lysine N-methyltransferase
CAPN2 calpain 2, (m/II) large subunit
CCDC69 coiled-coil domain containing 69
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CORO7 coronin 7
CRY2 cryptochrome circadian clock 2
CTBS chitobiase, di-N-acetyl-
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DHRS9 dehydrogenase/reductase (SDR family) member 9
DOHH deoxyhypusine hydroxylase/monooxygenase
DUSP4 dual specificity phosphatase 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
ERP44 endoplasmic reticulum protein 44
ETV5 ets variant 5
F3 coagulation factor III (thromboplastin, tissue factor)
FLJ22184
FOSL1 FOS-like antigen 1
GJB3 gap junction protein, beta 3, 31kDa
GLB1L galactosidase, beta 1-like
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HDAC7 histone deacetylase 7
HLA-DMA major histocompatibility complex, class II, DM alpha
HPN hepsin
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT74 intraflagellar transport 74
IPO8 importin 8
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KDM4B lysine (K)-specific demethylase 4B
KDM5C lysine (K)-specific demethylase 5C
LINC00597 long intergenic non-protein coding RNA 597
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MITF microphthalmia-associated transcription factor
MST1L macrophage stimulating 1-like
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAAA N-acylethanolamine acid amidase
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NKX3-2 NK3 homeobox 2
NOL10 nucleolar protein 10
NR4A2 nuclear receptor subfamily 4, group A, member 2
PALM paralemmin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHA6 protocadherin alpha 6
PHLDA1 pleckstrin homology-like domain, family A, member 1
PTHLH parathyroid hormone-like hormone
RABGAP1L RAB GTPase activating protein 1-like
RANBP3 RAN binding protein 3
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPL23AP32 ribosomal protein L23a pseudogene 32
SAP30 Sin3A-associated protein, 30kDa
SEC24D SEC24 family member D
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SMA4 glucuronidase, beta pseudogene
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SND1-IT1 SND1 intronic transcript 1
SOX18 SRY (sex determining region Y)-box 18
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
ST7L suppression of tumorigenicity 7 like
STK11 serine/threonine kinase 11
STOML1 stomatin (EPB72)-like 1
TCTN2 tectonic family member 2
TMEM63A transmembrane protein 63A
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TP63 tumor protein p63
TTC9 tetratricopeptide repeat domain 9
TUBA3C tubulin, alpha 3c
UPK2 uroplakin 2
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS9D1 VPS9 domain containing 1
WAS Wiskott-Aldrich syndrome
ZCCHC14 zinc finger, CCHC domain containing 14
ZDHHC14 zinc finger, DHHC-type containing 14
ZFP36L2 ZFP36 ring finger protein-like 2
ZKSCAN5 zinc finger with KRAB and SCAN domains 5

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAM15 ADAM metallopeptidase domain 15
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
BAGE B melanoma antigen
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C19ORF73 chromosome 19 open reading frame 73
C5AR2 complement component 5a receptor 2
CA2 carbonic anhydrase II
CA5BP1 carbonic anhydrase VB pseudogene 1
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CEP85 centrosomal protein 85kDa
CES3 carboxylesterase 3
CHML choroideremia-like (Rab escort protein 2)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CIDEC cell death-inducing DFFA-like effector c
CLCN6 chloride channel, voltage-sensitive 6
CLDND1 claudin domain containing 1
CLGN calmegin
CORT cortistatin
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DCTN4 dynactin 4 (p62)
DEAF1 DEAF1 transcription factor
DSE dermatan sulfate epimerase
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELOVL4 ELOVL fatty acid elongase 4
ERCC4 excision repair cross-complementation group 4
EXOC5 exocyst complex component 5
FLJ21369 uncharacterized protein FLJ21369
FNTB farnesyltransferase, CAAX box, beta
GAMT guanidinoacetate N-methyltransferase
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GOLGA8B golgin A8 family, member B
GSTCD glutathione S-transferase, C-terminal domain containing
HIST1H2BJ histone cluster 1, H2bj
IDI2-AS1 IDI2 antisense RNA 1
ITPKB inositol-trisphosphate 3-kinase B
KLF2 Kruppel-like factor 2
KRT83 keratin 83, type II
LIG4 ligase IV, DNA, ATP-dependent
LMNB1 lamin B1
LNPEP leucyl/cystinyl aminopeptidase
LRRC17 leucine rich repeat containing 17
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LZTFL1 leucine zipper transcription factor-like 1
METTL16 methyltransferase like 16
MMRN2 multimerin 2
MUC6 mucin 6, oligomeric mucus/gel-forming
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NIPAL2 NIPA-like domain containing 2
NMD3 NMD3 ribosome export adaptor
NPFFR1 neuropeptide FF receptor 1
NUP62CL nucleoporin 62kDa C-terminal like
PCDHGB5 protocadherin gamma subfamily B, 5
PDZRN3 PDZ domain containing ring finger 3
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLA2G3 phospholipase A2, group III
PNRC1 proline-rich nuclear receptor coactivator 1
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
QPCTL glutaminyl-peptide cyclotransferase-like
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB23 RAB23, member RAS oncogene family
RAB30 RAB30, member RAS oncogene family
RAB33A RAB33A, member RAS oncogene family
RANBP17 RAN binding protein 17
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
REM1 RAS (RAD and GEM)-like GTP-binding 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
SCG2 secretogranin II
SDS serine dehydratase
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SP1 Sp1 transcription factor
SRSF8 serine/arginine-rich splicing factor 8
STK16 serine/threonine kinase 16
STXBP3 syntaxin binding protein 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAGLN transgelin
TET3 tet methylcytosine dioxygenase 3
TEX14 testis expressed 14
TMEM230 transmembrane protein 230
TMEM38B transmembrane protein 38B
TRIM36 tripartite motif containing 36
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
YIPF5 Yip1 domain family, member 5
ZBTB22 zinc finger and BTB domain containing 22
ZBTB44 zinc finger and BTB domain containing 44
ZBTB6 zinc finger and BTB domain containing 6
ZNF492 zinc finger protein 492
ZNF573 zinc finger protein 573
ZNF646 zinc finger protein 646
ZNF747 zinc finger protein 747
ZW10 zw10 kinetochore protein