PDGFR-beta signaling pathway Gene Set

Dataset PID Pathways
Category structural or functional annotations
Type pathway
Description A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. (Gene Ontology, GO_0035791)
External Link http://public.ndexbio.org/#/network/c901a3e4-6194-11e5-8ac5-06603eb7f303
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Genes

125 proteins participating in the PDGFR-beta signaling pathway pathway from the PID Pathways dataset.

Symbol Name
ABI1 abl-interactor 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTN4 actinin, alpha 4
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGAP35 Rho GTPase activating protein 35
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
BAIAP2 BAI1-associated protein 2
BCAR1 breast cancer anti-estrogen resistance 1
BLK BLK proto-oncogene, Src family tyrosine kinase
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSK c-src tyrosine kinase
CTTN cortactin
CYFIP2 cytoplasmic FMR1 interacting protein 2
DNM2 dynamin 2
DOCK4 dedicator of cytokinesis 4
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELK1 ELK1, member of ETS oncogene family
EPS8 epidermal growth factor receptor pathway substrate 8
FGR FGR proto-oncogene, Src family tyrosine kinase
FOS FBJ murine osteosarcoma viral oncogene homolog
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GRB10 growth factor receptor-bound protein 10
GRB2 growth factor receptor-bound protein 2
HCK HCK proto-oncogene, Src family tyrosine kinase
HRAS Harvey rat sarcoma viral oncogene homolog
IQGAP1 IQ motif containing GTPase activating protein 1
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK2 Janus kinase 2
JUN jun proto-oncogene
JUND jun D proto-oncogene
KSR1 kinase suppressor of ras 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LRP1 low density lipoprotein receptor-related protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOCD myocardin
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
NCKAP1 NCK-associated protein 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDGFB platelet-derived growth factor beta polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCG1 phospholipase C, gamma 1
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PTEN phosphatase and tensin homolog
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRJ protein tyrosine phosphatase, receptor type, J
RAB4A RAB4A, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RHOA ras homolog family member A
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
S1PR1 sphingosine-1-phosphate receptor 1
SFN stratifin
SIPA1 signal-induced proliferation-associated 1
SLA Src-like-adaptor
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SOS1 son of sevenless homolog 1 (Drosophila)
SPHK1 sphingosine kinase 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRF serum response factor (c-fos serum response element-binding transcription factor)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TAGLN transgelin
USP6NL USP6 N-terminal like
VAV2 vav 2 guanine nucleotide exchange factor
WASF2 WAS protein family, member 2
WASL Wiskott-Aldrich syndrome-like
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta