Overweight Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

152 genes associated with the Overweight phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACAT1 acetyl-CoA acetyltransferase 1
ACE angiotensin I converting enzyme
ADAM12 ADAM metallopeptidase domain 12
ADD1 adducin 1 (alpha)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRA2A adrenoceptor alpha 2A
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGRP agouti related neuropeptide
AHSG alpha-2-HS-glycoprotein
AMD1 adenosylmethionine decarboxylase 1
ANGPTL4 angiopoietin-like 4
ANKK1 ankyrin repeat and kinase domain containing 1
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
AR androgen receptor
ARHGAP35 Rho GTPase activating protein 35
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BDNF brain-derived neurotrophic factor
BMP2 bone morphogenetic protein 2
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CAPN10 calpain 10
CARTPT CART prepropeptide
CETP cholesteryl ester transfer protein, plasma
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLOCK clock circadian regulator
CNR1 cannabinoid receptor 1 (brain)
CNTF ciliary neurotrophic factor
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL18A1 collagen, type XVIII, alpha 1
COMT catechol-O-methyltransferase
CRTC3 CREB regulated transcription coactivator 3
CRY2 cryptochrome circadian clock 2
CSK c-src tyrosine kinase
CSN3 casein kappa
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
DRD2 dopamine receptor D2
DRD4 dopamine receptor D4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRG estrogen-related receptor gamma
ETV5 ets variant 5
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FAAH fatty acid amide hydrolase
FABP2 fatty acid binding protein 2, intestinal
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAIM2 Fas apoptotic inhibitory molecule 2
FFAR1 free fatty acid receptor 1
FHIT fragile histidine triad
FNDC5 fibronectin type III domain containing 5
FTO fat mass and obesity associated
FUS FUS RNA binding protein
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GHR growth hormone receptor
GHSR growth hormone secretagogue receptor
GIPR gastric inhibitory polypeptide receptor
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNPDA2 glucosamine-6-phosphate deaminase 2
GPC5 glypican 5
GRB10 growth factor receptor-bound protein 10
GRIK3 glutamate receptor, ionotropic, kainate 3
HFE hemochromatosis
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HNF1A HNF1 homeobox A
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IL6 interleukin 6
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSIG2 insulin induced gene 2
IRS1 insulin receptor substrate 1
KCTD15 potassium channel tetramerization domain containing 15
KLF7 Kruppel-like factor 7 (ubiquitous)
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LIPC lipase, hepatic
LIPE lipase, hormone-sensitive
LIPG lipase, endothelial
MAOA monoamine oxidase A
MC4R melanocortin 4 receptor
MCHR1 melanin-concentrating hormone receptor 1
MEP1A meprin A, alpha (PABA peptide hydrolase)
MTCH2 mitochondrial carrier 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1B melatonin receptor 1B
MYLIP myosin regulatory light chain interacting protein
NEGR1 neuronal growth regulator 1
NMB neuromedin B
NMU neuromedin U
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPAS2 neuronal PAS domain protein 2
NPC1 Niemann-Pick disease, type C1
NPY neuropeptide Y
NPY2R neuropeptide Y receptor Y2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR5A2 nuclear receptor subfamily 5, group A, member 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK9 proprotein convertase subtilisin/kexin type 9
PDC phosducin
PER2 period circadian clock 2
PER3 period circadian clock 3
PFKP phosphofructokinase, platelet
PKLR pyruvate kinase, liver and RBC
PLIN1 perilipin 1
PNPLA3 patatin-like phospholipase domain containing 3
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PSRC1 proline/serine-rich coiled-coil 1
RBP4 retinol binding protein 4, plasma
RETN resistin
RIC3 RIC3 acetylcholine receptor chaperone
RNLS renalase, FAD-dependent amine oxidase
SCARB1 scavenger receptor class B, member 1
SEC16B SEC16 homolog B (S. cerevisiae)
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SH2B1 SH2B adaptor protein 1
SIRT1 sirtuin 1
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
STK39 serine threonine kinase 39
STX1A syntaxin 1A (brain)
TAS1R2 taste receptor, type 1, member 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TLR4 toll-like receptor 4
TMEM18 transmembrane protein 18
TNF tumor necrosis factor
TP53 tumor protein p53
TRIB1 tribbles pseudokinase 1
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
VEGFA vascular endothelial growth factor A
WDTC1 WD and tetratricopeptide repeats 1