Obesity, Morbid Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

120 genes associated with the Obesity, Morbid phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACE angiotensin I converting enzyme
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADRA2A adrenoceptor alpha 2A
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
APOC3 apolipoprotein C-III
APOE apolipoprotein E
AQP7 aquaporin 7
BDNF brain-derived neurotrophic factor
CAPN10 calpain 10
CD163 CD163 molecule
CETP cholesteryl ester transfer protein, plasma
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CPE carboxypeptidase E
CXCL9 chemokine (C-X-C motif) ligand 9
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DGAT1 diacylglycerol O-acyltransferase 1
DIO2 deiodinase, iodothyronine, type II
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DOCK5 dedicator of cytokinesis 5
DPP4 dipeptidyl-peptidase 4
DRD2 dopamine receptor D2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
ETV5 ets variant 5
F5 coagulation factor V (proaccelerin, labile factor)
FAAH fatty acid amide hydrolase
FABP2 fatty acid binding protein 2, intestinal
FAIM2 Fas apoptotic inhibitory molecule 2
FRAS1 Fraser extracellular matrix complex subunit 1
FTO fat mass and obesity associated
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GCKR glucokinase (hexokinase 4) regulator
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNPDA2 glucosamine-6-phosphate deaminase 2
GPX1 glutathione peroxidase 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IFI30 interferon, gamma-inducible protein 30
IL15 interleukin 15
IL18 interleukin 18
IL6 interleukin 6
INPP1 inositol polyphosphate-1-phosphatase
INS insulin
INSIG2 insulin induced gene 2
IRS1 insulin receptor substrate 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD15 potassium channel tetramerization domain containing 15
LCORL ligand dependent nuclear receptor corepressor-like
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPE lipase, hormone-sensitive
LIPF lipase, gastric
LPL lipoprotein lipase
LYPLAL1 lysophospholipase-like 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MC5R melanocortin 5 receptor
MCHR1 melanin-concentrating hormone receptor 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTCH2 mitochondrial carrier 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAMPT nicotinamide phosphoribosyltransferase
NAP1L5 nucleosome assembly protein 1-like 5
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D
NCAN neurocan
NDN necdin, melanoma antigen (MAGE) family member
NEGR1 neuronal growth regulator 1
NPC1 Niemann-Pick disease, type C1
NPY neuropeptide Y
NPY2R neuropeptide Y receptor Y2
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OPRM1 opioid receptor, mu 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PNPLA3 patatin-like phospholipase domain containing 3
POMC proopiomelanocortin
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R3B protein phosphatase 1, regulatory subunit 3B
PRL prolactin
PRRC2A proline-rich coiled-coil 2A
PTER phosphotriesterase related
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PXDNL peroxidasin-like
PYY peptide YY
PYY2 peptide YY, 2 (pseudogene)
RETN resistin
RIC3 RIC3 acetylcholine receptor chaperone
RREB1 ras responsive element binding protein 1
SCARB1 scavenger receptor class B, member 1
SEC16B SEC16 homolog B (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2B1 SH2B adaptor protein 1
SIRT1 sirtuin 1
SLC17A1 solute carrier family 17 (organic anion transporter), member 1
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
STEAP4 STEAP family member 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TMEM18 transmembrane protein 18
TNF tumor necrosis factor
TSLP thymic stromal lymphopoietin
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)