Notch signaling pathway Gene Set

Dataset PID Pathways
Category structural or functional annotations
Type pathway
Description A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. (Gene Ontology, GO_0007219)
External Link http://public.ndexbio.org/#/network/88f83518-6194-11e5-8ac5-06603eb7f303
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Genes

59 proteins participating in the Notch signaling pathway pathway from the PID Pathways dataset.

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADAM12 ADAM metallopeptidase domain 12
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCND1 cyclin D1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CNTN1 contactin 1
CNTN6 contactin 6
CTBP1 C-terminal binding protein 1
CUL1 cullin 1
DLK1 delta-like 1 homolog (Drosophila)
DLL1 delta-like 1 (Drosophila)
DLL3 delta-like 3 (Drosophila)
DLL4 delta-like 4 (Drosophila)
DNER delta/notch-like EGF repeat containing
DNM1 dynamin 1
DTX1 deltex 1, E3 ubiquitin ligase
ENO1 enolase 1, (alpha)
EP300 E1A binding protein p300
EPS15 epidermal growth factor receptor pathway substrate 15
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FURIN furin (paired basic amino acid cleaving enzyme)
GATA3 GATA binding protein 3
HDAC1 histone deacetylase 1
IL4 interleukin 4
ITCH itchy E3 ubiquitin protein ligase
JAG1 jagged 1
JAG2 jagged 2
KDM1A lysine (K)-specific demethylase 1A
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
MAML1 mastermind-like 1 (Drosophila)
MAML2 mastermind-like 2 (Drosophila)
MARK2 MAP/microtubule affinity-regulating kinase 2
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
MIB1 mindbomb E3 ubiquitin protein ligase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NCSTN nicastrin
NEURL1 neuralized E3 ubiquitin protein ligase 1
NOTCH1 notch 1
NOTCH2 notch 2
NOTCH3 notch 3
NOTCH4 notch 4
NUMB numb homolog (Drosophila)
PSEN1 presenilin 1
PSENEN presenilin enhancer gamma secretase subunit
PTCRA pre T-cell antigen receptor alpha
RAB11A RAB11A, member RAS oncogene family
RBBP8 retinoblastoma binding protein 8
RBPJ recombination signal binding protein for immunoglobulin kappa J region
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SPEN spen family transcriptional repressor
SSPO SCO-spondin
YY1 YY1 transcription factor