Nephrotic Syndrome Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Xref MGI. (Human Disease Ontology, DOID_1184)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D009404
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Genes

289 genes/proteins associated with the disease Nephrotic Syndrome from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
F3 coagulation factor III (thromboplastin, tissue factor) 2.88009
NCK1 NCK adaptor protein 1 2.88009
ALB albumin 2.88009
FGF2 fibroblast growth factor 2 (basic) 2.88009
CD2 CD2 molecule 2.88009
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.88009
GUCA2B guanylate cyclase activator 2B (uroguanylin) 2.88009
IL2 interleukin 2 2.88009
A2M alpha-2-macroglobulin 2.88009
SOD2 superoxide dismutase 2, mitochondrial 2.88009
MMP1 matrix metallopeptidase 1 2.88009
TGFB1 transforming growth factor, beta 1 2.88009
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.88009
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.88009
NCK2 NCK adaptor protein 2 2.88009
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.88009
GPC5 glypican 5 2.88009
TF transferrin 2.88009
COL4A1 collagen, type IV, alpha 1 2.88009
COL4A2 collagen, type IV, alpha 2 2.88009
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.88009
COL1A1 collagen, type I, alpha 1 2.88009
TNF tumor necrosis factor 2.41344
IL1B interleukin 1, beta 2.32541
IL6 interleukin 6 2.30235
BCL2 B-cell CLL/lymphoma 2 2.27387
BAX BCL2-associated X protein 2.2619
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.21258
CCL2 chemokine (C-C motif) ligand 2 2.20691
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.13846
IFNG interferon, gamma 2.13327
IL4 interleukin 4 2.10863
NOS2 nitric oxide synthase 2, inducible 2.07059
HMOX1 heme oxygenase 1 2.04593
VCAM1 vascular cell adhesion molecule 1 2.04306
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.04151
TIMP1 TIMP metallopeptidase inhibitor 1 2.02726
VEGFA vascular endothelial growth factor A 2.00996
EDN1 endothelin 1 2.00096
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.99948
FOS FBJ murine osteosarcoma viral oncogene homolog 1.98784
FAS Fas cell surface death receptor 1.96208
IL10 interleukin 10 1.95858
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.9495
MMP2 matrix metallopeptidase 2 1.91435
TP53 tumor protein p53 1.91435
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.91017
CAT catalase 1.90836
MPO myeloperoxidase 1.88556
IGF1 insulin-like growth factor 1 (somatomedin C) 1.88376
DDIT3 DNA-damage-inducible transcript 3 1.87575
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.85729
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.8418
FASLG Fas ligand (TNF superfamily, member 6) 1.8418
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.82341
MAPK1 mitogen-activated protein kinase 1 1.81958
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.81811
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.81593
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.81375
GSTP1 glutathione S-transferase pi 1 1.7893
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.7811
IL1A interleukin 1, alpha 1.77878
ICAM1 intercellular adhesion molecule 1 1.77878
REN renin 1.7544
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.74903
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.74661
BCL2L1 BCL2-like 1 1.73738
PPARG peroxisome proliferator-activated receptor gamma 1.72884
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.72717
S100A9 S100 calcium binding protein A9 1.72199
BIRC5 baculoviral IAP repeat containing 5 1.71276
CXCL8 chemokine (C-X-C motif) ligand 8 1.71009
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.69888
NPPA natriuretic peptide A 1.69701
JUN jun proto-oncogene 1.68169
NPPB natriuretic peptide B 1.68084
CCND1 cyclin D1 1.67547
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.67159
MAPK3 mitogen-activated protein kinase 3 1.67159
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.66555
GSTM1 glutathione S-transferase mu 1 1.66446
PARP1 poly (ADP-ribose) polymerase 1 1.66317
CXCL10 chemokine (C-X-C motif) ligand 10 1.65665
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.65643
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.6428
CCL3 chemokine (C-C motif) ligand 3 1.64101
GCLM glutamate-cysteine ligase, modifier subunit 1.63116
APOE apolipoprotein E 1.62176
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 1.61805
GSK3B glycogen synthase kinase 3 beta 1.57735
GCLC glutamate-cysteine ligase, catalytic subunit 1.57641
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.57066
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.56239
NFE2L2 nuclear factor, erythroid 2-like 2 1.56044
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.55698
MKI67 marker of proliferation Ki-67 1.55255
HSPA8 heat shock 70kDa protein 8 1.54912
IL12A interleukin 12A 1.54548
MMP9 matrix metallopeptidase 9 1.54086
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 1.54038
IL5 interleukin 5 1.53917
IL12B interleukin 12B 1.53844
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.53699
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.53159
PPARA peroxisome proliferator-activated receptor alpha 1.52938
NQO1 NAD(P)H dehydrogenase, quinone 1 1.52515
TIMP2 TIMP metallopeptidase inhibitor 2 1.52388
SOD1 superoxide dismutase 1, soluble 1.52388
RB1 retinoblastoma 1 1.51759
NOS3 nitric oxide synthase 3 (endothelial cell) 1.51355
CCL5 chemokine (C-C motif) ligand 5 1.50903
DUSP1 dual specificity phosphatase 1 1.50599
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 1.49992
PCNA proliferating cell nuclear antigen 1.49967
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.48864
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.48761
IGFBP3 insulin-like growth factor binding protein 3 1.48659
SPP1 secreted phosphoprotein 1 1.48351
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.47915
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.47889
COL3A1 collagen, type III, alpha 1 1.47348
BAK1 BCL2-antagonist/killer 1 1.46701
GADD45A growth arrest and DNA-damage-inducible, alpha 1.46409
SELL selectin L 1.46015
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.45697
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.44382
TLR4 toll-like receptor 4 1.44219
CYP3A cytochrome P450, family 3, subfamily A 1.43946
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 1.43782
C3 complement component 3 1.43401
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.4087
EGR1 early growth response 1 1.40429
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.40288
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.40176
THBS1 thrombospondin 1 1.40092
ANXA2 annexin A2 1.40092
CXCL2 chemokine (C-X-C motif) ligand 2 1.39785
CHUK conserved helix-loop-helix ubiquitous kinase 1.39422
BIRC3 baculoviral IAP repeat containing 3 1.38355
CCNA2 cyclin A2 1.37619
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.37475
GSTT1 glutathione S-transferase theta 1 1.37132
SELE selectin E 1.35676
FN1 fibronectin 1 1.35647
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.34547
LCN2 lipocalin 2 1.34053
GSTM3 glutathione S-transferase mu 3 (brain) 1.3385
VIM vimentin 1.33791
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.33434
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.33169
MCL1 myeloid cell leukemia 1 1.32964
CDK1 cyclin-dependent kinase 1 1.32935
APP amyloid beta (A4) precursor protein 1.32786
TJP1 tight junction protein 1 1.32399
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.32339
PPARD peroxisome proliferator-activated receptor delta 1.31656
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.31119
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.30941
FASN fatty acid synthase 1.30482
HSPA1A heat shock 70kDa protein 1A 1.30329
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.30208
GSTA1 glutathione S-transferase alpha 1 1.30177
S100A8 S100 calcium binding protein A8 1.29719
AQP2 aquaporin 2 (collecting duct) 1.28827
ACTA2 actin, alpha 2, smooth muscle, aorta 1.28796
APOB apolipoprotein B 1.28088
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.27936
CFLAR CASP8 and FADD-like apoptosis regulator 1.27193
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.27009
TXNRD1 thioredoxin reductase 1 1.26794
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 1.26732
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.26421
CRP C-reactive protein, pentraxin-related 1.26205
EGFR epidermal growth factor receptor 1.25899
CD36 CD36 molecule (thrombospondin receptor) 1.24874
PLAT plasminogen activator, tissue 1.24528
GDF15 growth differentiation factor 15 1.24528
GJA1 gap junction protein, alpha 1, 43kDa 1.23712
MAPK8 mitogen-activated protein kinase 8 1.23648
GPX1 glutathione peroxidase 1 1.23392
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.22177
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.22112
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.21951
DHFR dihydrofolate reductase 1.21076
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.21011
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 1.20816
PDGFA platelet-derived growth factor alpha polypeptide 1.20328
CP ceruloplasmin (ferroxidase) 1.19672
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.19246
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.19113
CALR calreticulin 1.18849
F2 coagulation factor II (thrombin) 1.18751
BID BH3 interacting domain death agonist 1.18159
EGF epidermal growth factor 1.17728
EIF1AX eukaryotic translation initiation factor 1A, X-linked 1.1753
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.17497
ADRB2 adrenoceptor beta 2, surface 1.17497
EPO erythropoietin 1.17464
GPX2 glutathione peroxidase 2 1.17464
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.173
SAT1 spermidine/spermine N1-acetyltransferase 1 1.17034
ADM adrenomedullin 1.17
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.169
PKLR pyruvate kinase, liver and RBC 1.16733
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.166
ANXA5 annexin A5 1.16567
SCNN1A sodium channel, non voltage gated 1 alpha subunit 1.16104
TLR2 toll-like receptor 2 1.16104
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.16104
CDK2 cyclin-dependent kinase 2 1.16035
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.15967
BIRC2 baculoviral IAP repeat containing 2 1.15899
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.15492
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.15223
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.15022
CTGF connective tissue growth factor 1.14404
UNG uracil-DNA glycosylase 1.14336
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.14302
HSF1 heat shock transcription factor 1 1.14064
HSPA1B heat shock 70kDa protein 1B 1.13724
S100A4 S100 calcium binding protein A4 1.13484
BAD BCL2-associated agonist of cell death 1.13415
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 1.13211
STAT1 signal transducer and activator of transcription 1, 91kDa 1.12771
TBX21 T-box 21 1.12771
FOXO1 forkhead box O1 1.12668
IL2RA interleukin 2 receptor, alpha 1.12668
CLU clusterin 1.12426
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.11843
IFRD1 interferon-related developmental regulator 1 1.11843
TFRC transferrin receptor 1.11809
NRP1 neuropilin 1 1.11571
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.11325
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.1129
MAPT microtubule-associated protein tau 1.11081
ATF4 activating transcription factor 4 1.10907
LEP leptin 1.10769
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 1.10282
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.10033
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.09681
AQP3 aquaporin 3 (Gill blood group) 1.09506
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.09506
FOXP3 forkhead box P3 1.09262
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.09011
SQSTM1 sequestosome 1 1.08975
AVP arginine vasopressin 1.08513
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.08407
IRF1 interferon regulatory factor 1 1.08266
KLF6 Kruppel-like factor 6 1.08019
LOX lysyl oxidase 1.08019
KLF2 Kruppel-like factor 2 1.07911
EDNRA endothelin receptor type A 1.07518
PLAU plasminogen activator, urokinase 1.07518
CCL20 chemokine (C-C motif) ligand 20 1.06808
HBEGF heparin-binding EGF-like growth factor 1.06808
TYMS thymidylate synthetase 1.06771
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.06116
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.05648
CD83 CD83 molecule 1.0561
RAD50 RAD50 homolog (S. cerevisiae) 1.0561
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1.05498
TIMP3 TIMP metallopeptidase inhibitor 3 1.05423
PTGER4 prostaglandin E receptor 4 (subtype EP4) 1.05274
CRIP1 cysteine-rich protein 1 (intestinal) 1.05089
GSR glutathione reductase 1.04978
RHOA ras homolog family member A 1.04721
ATF3 activating transcription factor 3 1.04647
ETFB electron-transfer-flavoprotein, beta polypeptide 1.04611
CDA cytidine deaminase 1.04611
MAPK14 mitogen-activated protein kinase 14 1.04501
CYBA cytochrome b-245, alpha polypeptide 1.04501
CDK5 cyclin-dependent kinase 5 1.04126
RBPMS RNA binding protein with multiple splicing 1.03641
SLCO4C1 solute carrier organic anion transporter family, member 4C1 1.0353
RRM2 ribonucleotide reductase M2 1.02746
SLCO2A1 solute carrier organic anion transporter family, member 2A1 1.02746
CCNB2 cyclin B2 1.02299
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.02299
H2AFX H2A histone family, member X 1.02003
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 1.02003
PON1 paraoxonase 1 1.02003
G6PD glucose-6-phosphate dehydrogenase 1.01852
IVNS1ABP influenza virus NS1A binding protein 1.01852
HSPA7 heat shock 70kDa protein 7 (HSP70B) 1.01663
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.01625
GPX3 glutathione peroxidase 3 1.01474
EDNRB endothelin receptor type B 1.01474
IL1RN interleukin 1 receptor antagonist 1.01474
TGFB2 transforming growth factor, beta 2 1.01249