Neoplasms, Second Primary Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

255 genes associated with the Neoplasms, Second Primary phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACVR1B activin A receptor, type IB
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADH6 alcohol dehydrogenase 6 (class V)
AGO1 argonaute RISC catalytic component 1
AHR aryl hydrocarbon receptor
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANGPT4 angiopoietin 4
ANGPTL1 angiopoietin-like 1
APC adenomatous polyposis coli
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATG4A autophagy related 4A, cysteine peptidase
ATG9A autophagy related 9A
ATM ATM serine/threonine kinase
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
AURKA aurora kinase A
AXIN2 axin 2
BAG1 BCL2-associated athanogene
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAX BCL2-associated X protein
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L2 BCL2-like 2
BIRC5 baculoviral IAP repeat containing 5
BIRC6 baculoviral IAP repeat containing 6
BMF Bcl2 modifying factor
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CA9 carbonic anhydrase IX
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD34 CD34 molecule
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CDC25C cell division cycle 25C
CDC7 cell division cycle 7
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHEK2 checkpoint kinase 2
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
COL18A1 collagen, type XVIII, alpha 1
COX18 COX18 cytochrome c oxidase assembly factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DGCR8 DGCR8 microprocessor complex subunit
DICER1 dicer 1, ribonuclease type III
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DROSHA drosha, ribonuclease type III
E2F2 E2F transcription factor 2
E2F7 E2F transcription factor 7
EGFR epidermal growth factor receptor
EMC8 ER membrane protein complex subunit 8
ENDOV endonuclease V
EPHX2 epoxide hydrolase 2, cytoplasmic
ERCC2 excision repair cross-complementation group 2
ERCC5 excision repair cross-complementation group 5
ERN1 endoplasmic reticulum to nucleus signaling 1
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FANCD2 Fanconi anemia, complementation group D2
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FEN1 flap structure-specific endonuclease 1
FGF2 fibroblast growth factor 2 (basic)
FGF5 fibroblast growth factor 5
FGF9 fibroblast growth factor 9
FGFR3 fibroblast growth factor receptor 3
FLT3 fms-related tyrosine kinase 3
FOXO1 forkhead box O1
FZD3 frizzled class receptor 3
FZD4 frizzled class receptor 4
GC group-specific component (vitamin D binding protein)
GEMIN4 gem (nuclear organelle) associated protein 4
GH1 growth hormone 1
GHITM growth hormone inducible transmembrane protein
GHR growth hormone receptor
GHRHR growth hormone releasing hormone receptor
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
GPER1 G protein-coupled estrogen receptor 1
GPX1 glutathione peroxidase 1
GPX7 glutathione peroxidase 7
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTM4 glutathione S-transferase mu 4
GSTM5 glutathione S-transferase mu 5
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLX H2.0-like homeobox
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IDE insulin-degrading enzyme
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2-AS IGF2 antisense RNA
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IHH indian hedgehog
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL1R1 interleukin 1 receptor, type I
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAK2 Janus kinase 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
MBD1 methyl-CpG binding domain protein 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MGMT O-6-methylguanine-DNA methyltransferase
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MRC2 mannose receptor, C type 2
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
NEIL2 nei endonuclease VIII-like 2 (E. coli)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NHEJ1 nonhomologous end-joining factor 1
NODAL nodal growth differentiation factor
NOTCH1 notch 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OGG1 8-oxoguanine DNA glycosylase
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PGRMC2 progesterone receptor membrane component 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POLH polymerase (DNA directed), eta
PON1 paraoxonase 1
PROM1 prominin 1
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTCH2 patched 2
PTEN phosphatase and tensin homolog
RAD51 RAD51 recombinase
RAD51D RAD51 paralog D
RAN RAN, member RAS oncogene family
RB1 retinoblastoma 1
RET ret proto-oncogene
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RGS11 regulator of G-protein signaling 11
RGS12 regulator of G-protein signaling 12
RGS13 regulator of G-protein signaling 13
RGS14 regulator of G-protein signaling 14
RGS16 regulator of G-protein signaling 16
RGS18 regulator of G-protein signaling 18
RGS2 regulator of G-protein signaling 2
RGS20 regulator of G-protein signaling 20
RGS22 regulator of G-protein signaling 22
RGS3 regulator of G-protein signaling 3
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RGS7 regulator of G-protein signaling 7
RGS8 regulator of G-protein signaling 8
RGS9 regulator of G-protein signaling 9
RICTOR RPTOR independent companion of MTOR, complex 2
RING1 ring finger protein 1
RNF2 ring finger protein 2
RPA1 replication protein A1, 70kDa
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RRM1 ribonucleotide reductase M1
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RUNX1 runt-related transcription factor 1
RXRA retinoid X receptor, alpha
SETD1A SET domain containing 1A
SHH sonic hedgehog
SIRT3 sirtuin 3
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SMC1B structural maintenance of chromosomes 1B
SMO smoothened, frizzled class receptor
SNAI1 snail family zinc finger 1
SOS1 son of sevenless homolog 1 (Drosophila)
SP1 Sp1 transcription factor
SPP1 secreted phosphoprotein 1
SST somatostatin
SSTR1 somatostatin receptor 1
SSTR2 somatostatin receptor 2
SUFU suppressor of fused homolog (Drosophila)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SULT4A1 sulfotransferase family 4A, member 1
TET2 tet methylcytosine dioxygenase 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP73 tumor protein p73
TPMT thiopurine S-methyltransferase
TSC1 tuberous sclerosis 1
TXN2 thioredoxin 2
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3
UGT3A2 UDP glycosyltransferase 3 family, polypeptide A2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WNT11 wingless-type MMTV integration site family, member 11
WNT2B wingless-type MMTV integration site family, member 2B
WT1 Wilms tumor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPO5 exportin 5
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)