Neoplasm Invasiveness Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

394 genes associated with the Neoplasm Invasiveness phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACVRL1 activin A receptor type II-like 1
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALK anaplastic lymphoma receptor tyrosine kinase
ANK2 ankyrin 2, neuronal
ANKRD55 ankyrin repeat domain 55
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AR androgen receptor
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARID1A AT rich interactive domain 1A (SWI-like)
ARMC2 armadillo repeat containing 2
ATM ATM serine/threonine kinase
AURKA aurora kinase A
AXIN1 axin 1
AXIN2 axin 2
BCAS1 breast carcinoma amplified sequence 1
BCL2 B-cell CLL/lymphoma 2
BICD1 bicaudal D homolog 1 (Drosophila)
BLM Bloom syndrome, RecQ helicase-like
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C2ORF80 chromosome 2 open reading frame 80
CAMK1D calcium/calmodulin-dependent protein kinase ID
CAPG capping protein (actin filament), gelsolin-like
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CCNE1 cyclin E1
CCNH cyclin H
CCR2 chemokine (C-C motif) receptor 2
CD226 CD226 molecule
CD24 CD24 molecule
CD28 CD28 molecule
CD83 CD83 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CERS4 ceramide synthase 4
CHEK2 checkpoint kinase 2
CHMP4C charged multivesicular body protein 4C
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
COL18A1 collagen, type XVIII, alpha 1
COL4A2 collagen, type IV, alpha 2
COMT catechol-O-methyltransferase
CREB5 cAMP responsive element binding protein 5
CRP C-reactive protein, pentraxin-related
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DDB2 damage-specific DNA binding protein 2, 48kDa
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOCK2 dedicator of cytokinesis 2
DPYD dihydropyrimidine dehydrogenase
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELMO1 engulfment and cell motility 1
EMP3 epithelial membrane protein 3
ENG endoglin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ERCC8 excision repair cross-complementation group 8
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRB estrogen-related receptor beta
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FANCA Fanconi anemia, complementation group A
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FANCG Fanconi anemia, complementation group G
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FOXE1 forkhead box E1
FOXP3 forkhead box P3
FRZB frizzled-related protein
FSTL1 follistatin-like 1
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18
GDNF glial cell derived neurotrophic factor
GNAS GNAS complex locus
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRHR gonadotropin-releasing hormone receptor
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPX1 glutathione peroxidase 1
GSK3B glycogen synthase kinase 3 beta
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTO1 glutathione S-transferase omega 1
GSTO2 glutathione S-transferase omega 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GSTZ1 glutathione S-transferase zeta 1
H19 H19, imprinted maternally expressed transcript (non-protein coding)
H2AFY2 H2A histone family, member Y2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HNF1B HNF1 homeobox B
HP haptoglobin
HPN hepsin
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
IFNG interferon, gamma
IFNK interferon, kappa
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL12B interleukin 12B
IL15 interleukin 15
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
IL6 interleukin 6
IL6R interleukin 6 receptor
INSIG2 insulin induced gene 2
IRF4 interferon regulatory factor 4
IRS1 insulin receptor substrate 1
IRX4 iroquois homeobox 4
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA6 integrin, alpha 6
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KALRN kalirin, RhoGEF kinase
KDR kinase insert domain receptor
KIFAP3 kinesin-associated protein 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLK3 kallikrein-related peptidase 3
KRAS Kirsten rat sarcoma viral oncogene homolog
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS9 lectin, galactoside-binding, soluble, 9
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LSP1 lymphocyte-specific protein 1
LTA lymphotoxin alpha
LTBP1 latent transforming growth factor beta binding protein 1
LTBP2 latent transforming growth factor beta binding protein 2
LTBP4 latent transforming growth factor beta binding protein 4
LUM lumican
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIR146A microRNA 146a
MIR196A2 microRNA 196a-2
MITF microphthalmia-associated transcription factor
MLH1 mutL homolog 1
MLH3 mutL homolog 3
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MPG N-methylpurine-DNA glycosylase
MPO myeloperoxidase
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MRVI1 murine retrovirus integration site 1 homolog
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MT-ND3 NADH dehydrogenase, subunit 3 (complex I)
MTAP methylthioadenosine phosphorylase
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTSS1 metastasis suppressor 1
MUTYH mutY homolog
MYO3B myosin IIIB
MYRF myelin regulatory factor
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NKX2-1 NK2 homeobox 1
NLK nemo-like kinase
NNMT nicotinamide N-methyltransferase
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRP1 neuropilin 1
NRP2 neuropilin 2
NXPH1 neurexophilin 1
OGG1 8-oxoguanine DNA glycosylase
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PLA2G10 phospholipase A2, group X
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PODXL podocalyxin-like
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLB polymerase (DNA directed), beta
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG polymerase (DNA directed), gamma
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLH polymerase (DNA directed), eta
POLI polymerase (DNA directed) iota
POLK polymerase (DNA directed) kappa
POLL polymerase (DNA directed), lambda
POLM polymerase (DNA directed), mu
POLQ polymerase (DNA directed), theta
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
POLR2D polymerase (RNA) II (DNA directed) polypeptide D
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLRMT polymerase (RNA) mitochondrial (DNA directed)
POT1 protection of telomeres 1
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRDM2 PR domain containing 2, with ZNF domain
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSD3 pleckstrin and Sec7 domain containing 3
PTCH1 patched 1
PTCH2 patched 2
PTEN phosphatase and tensin homolog
PTPN3 protein tyrosine phosphatase, non-receptor type 3
PTPRJ protein tyrosine phosphatase, receptor type, J
RAD23A RAD23 homolog A (S. cerevisiae)
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51 RAD51 recombinase
RAD51C RAD51 paralog C
RAD51L3-RFFL RAD51L3-RFFL readthrough
RAD52 RAD52 homolog (S. cerevisiae)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RB1 retinoblastoma 1
RECQL4 RecQ protein-like 4
RET ret proto-oncogene
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFC1 replication factor C (activator 1) 1, 145kDa
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RFX6 regulatory factor X, 6
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RHBDL2 rhomboid, veinlet-like 2 (Drosophila)
RNASE3 ribonuclease, RNase A family, 3
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
RYR1 ryanodine receptor 1 (skeletal)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHANK3 SH3 and multiple ankyrin repeat domains 3
SHH sonic hedgehog
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMO smoothened, frizzled class receptor
SOD2 superoxide dismutase 2, mitochondrial
SORCS2 sortilin-related VPS10 domain containing receptor 2
SPG20 spastic paraplegia 20 (Troyer syndrome)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYK spleen tyrosine kinase
TDG thymine-DNA glycosylase
TERF2 telomeric repeat binding factor 2
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TP63 tumor protein p63
TUB tubby bipartite transcription factor
TYMS thymidylate synthetase
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT8 UDP glycosyltransferase 8
UNG uracil-DNA glycosylase
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZHX2 zinc fingers and homeoboxes 2
ZNF462 zinc finger protein 462
ZNF718 zinc finger protein 718