NOTCH1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description notch 1|This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4851)
External Link http://www.ncbi.nlm.nih.gov/gene/4851
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315 interacting proteins for NOTCH1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALMS1 Alstrom syndrome protein 1
AMER1 APC membrane recruitment protein 1
AMOT angiomotin
AMOTL1 angiomotin like 1
AMOTL2 angiomotin like 2
ANAPC1 anaphase promoting complex subunit 1
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APC adenomatous polyposis coli
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
APP amyloid beta (A4) precursor protein
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARMC8 armadillo repeat containing 8
ARRB1 arrestin, beta 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AXIN1 axin 1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAG2 BCL2-associated athanogene 2
BAG5 BCL2-associated athanogene 5
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1
C14ORF166 chromosome 14 open reading frame 166
C18ORF8 chromosome 18 open reading frame 8
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAND1 cullin-associated and neddylation-dissociated 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC77 coiled-coil domain containing 77
CCDC85C coiled-coil domain containing 85C
CCDC88C coiled-coil domain containing 88C
CCNC cyclin C
CCP110 centriolar coiled coil protein 110kDa
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDC23 cell division cycle 23
CDC27 cell division cycle 27
CDK8 cyclin-dependent kinase 8
CENPJ centromere protein J
CEP192 centrosomal protein 192kDa
CEP295 centrosomal protein 295kDa
CEP72 centrosomal protein 72kDa
CEP85 centrosomal protein 85kDa
CEP89 centrosomal protein 89kDa
CGN cingulin
CHD4 chromodomain helicase DNA binding protein 4
CIR1 corepressor interacting with RBPJ, 1
CNOT1 CCR4-NOT transcription complex, subunit 1
CNTN1 contactin 1
CNTROB centrobin, centrosomal BRCA2 interacting protein
CPVL carboxypeptidase, vitellogenic-like
CREBBP CREB binding protein
CSPP1 centrosome and spindle pole associated protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYLD cylindromatosis (turban tumor syndrome)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DLL1 delta-like 1 (Drosophila)
DLL3 delta-like 3 (Drosophila)
DLL4 delta-like 4 (Drosophila)
DNM1 dynamin 1
DTX1 deltex 1, E3 ubiquitin ligase
DTX2 deltex 2, E3 ubiquitin ligase
EGFL7 EGF-like-domain, multiple 7
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EP300 E1A binding protein p300
EPN1 epsin 1
EPS15 epidermal growth factor receptor pathway substrate 15
ERC1 ELKS/RAB6-interacting/CAST family member 1
ERH enhancer of rudimentary homolog (Drosophila)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOS FBJ murine osteosarcoma viral oncogene homolog
FRYL FRY-like
FUBP3 far upstream element (FUSE) binding protein 3
FURIN furin (paired basic amino acid cleaving enzyme)
GATAD2B GATA zinc finger domain containing 2B
GFI1B growth factor independent 1B transcription repressor
GIGYF1 GRB10 interacting GYF protein 1
GPS1 G protein pathway suppressor 1
GRIP1 glutamate receptor interacting protein 1
GSK3B glycogen synthase kinase 3 beta
HCFC1 host cell factor C1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HDAC1 histone deacetylase 1
HDAC3 histone deacetylase 3
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLTF helicase-like transcription factor
HTATSF1 HIV-1 Tat specific factor 1
IFI16 interferon, gamma-inducible protein 16
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF2 IKAROS family zinc finger 2 (Helios)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
ILK integrin-linked kinase
INADL InaD-like (Drosophila)
IPO5 importin 5
ITCH itchy E3 ubiquitin protein ligase
JAG1 jagged 1
JAG2 jagged 2
JUN jun proto-oncogene
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KAT5 K(lysine) acetyltransferase 5
KDM1A lysine (K)-specific demethylase 1A
KIAA0368 KIAA0368
KIAA1462 KIAA1462
KIAA1549 KIAA1549
KIAA1671 KIAA1671
KIF2A kinesin heavy chain member 2A
KIF3A kinesin family member 3A
KPNB1 karyopherin (importin) beta 1
LATS2 large tumor suppressor kinase 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LIMD1 LIM domains containing 1
LIMK2 LIM domain kinase 2
LIN7C lin-7 homolog C (C. elegans)
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LZTS2 leucine zipper, putative tumor suppressor 2
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAML1 mastermind-like 1 (Drosophila)
MAML2 mastermind-like 2 (Drosophila)
MAML3 mastermind-like 3 (Drosophila)
MAMLD1 mastermind-like domain containing 1
MAPK1 mitogen-activated protein kinase 1
MAU2 MAU2 sister chromatid cohesion factor
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDN1 MDN1, midasin homolog (yeast)
MED23 mediator complex subunit 23
MED25 mediator complex subunit 25
MEF2C myocyte enhancer factor 2C
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MIA3 melanoma inhibitory activity family, member 3
MIB1 mindbomb E3 ubiquitin protein ligase 1
MIB2 mindbomb E3 ubiquitin protein ligase 2
MIPOL1 mirror-image polydactyly 1
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MOB1A MOB kinase activator 1A
MPDZ multiple PDZ domain protein
MPHOSPH9 M-phase phosphoprotein 9
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
NBEA neurobeachin
NCKAP1L NCK-associated protein 1-like
NCKAP5L NCK-associated protein 5-like
NCOR2 nuclear receptor corepressor 2
NCSTN nicastrin
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NIN ninein (GSK3B interacting protein)
NINL ninein-like
NME7 NME/NM23 family member 7
NOTCH2 notch 2
NOTCH3 notch 3
NOV nephroblastoma overexpressed
NUMB numb homolog (Drosophila)
NUMBL numb homolog (Drosophila)-like
NUP160 nucleoporin 160kDa
OFD1 oral-facial-digital syndrome 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARD3 par-3 family cell polarity regulator
PARP1 poly (ADP-ribose) polymerase 1
PBRM1 polybromo 1
PCM1 pericentriolar material 1
PDS5A PDS5 cohesin associated factor A
PDZD11 PDZ domain containing 11
PHF8 PHD finger protein 8
PHLDB2 pleckstrin homology-like domain, family B, member 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKP4 plakophilin 4
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
POFUT1 protein O-fucosyltransferase 1
POGLUT1 protein O-glucosyltransferase 1
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP6R1 protein phosphatase 6, regulatory subunit 1
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF19 pre-mRNA processing factor 19
PRPF6 pre-mRNA processing factor 6
PRPF8 pre-mRNA processing factor 8
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
PTBP1 polypyrimidine tract binding protein 1
PTBP3 polypyrimidine tract binding protein 3
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RAB6A RAB6A, member RAS oncogene family
RADIL Ras association and DIL domains
RANBP10 RAN binding protein 10
RANBP9 RAN binding protein 9
RASAL2 RAS protein activator like 2
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RBM10 RNA binding motif protein 10
RBM15 RNA binding motif protein 15
RBP3 retinol binding protein 3, interstitial
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFC1 replication factor C (activator 1) 1, 145kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RFX1 regulatory factor X, 1 (influences HLA class II expression)
RIF1 replication timing regulatory factor 1
RING1 ring finger protein 1
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
RNF2 ring finger protein 2
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPS27A ribosomal protein S27a
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
SART1 squamous cell carcinoma antigen recognized by T cells
SDCCAG3 serologically defined colon cancer antigen 3
SEC16A SEC16 homolog A (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SIPA1L1 signal-induced proliferation-associated 1 like 1
SIPA1L2 signal-induced proliferation-associated 1 like 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLFN11 schlafen family member 11
SLFN5 schlafen family member 5
SMAD3 SMAD family member 3
SMAD9 SMAD family member 9
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SNAI1 snail family zinc finger 1
SNW1 SNW domain containing 1
SORBS1 sorbin and SH3 domain containing 1
SPICE1 spindle and centriole associated protein 1
SRRT serrate, RNA effector molecule
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STK38 serine/threonine kinase 38
STXBP4 syntaxin binding protein 4
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBK1 TANK-binding kinase 1
TBKBP1 TBK1 binding protein 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCF12 transcription factor 12
TCHP trichoplein, keratin filament binding
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TMED2 transmembrane emp24 domain trafficking protein 2
TNPO1 transportin 1
TNRC6B trinucleotide repeat containing 6B
TOP2B topoisomerase (DNA) II beta 180kDa
TP53BP2 tumor protein p53 binding protein 2
TRAPPC10 trafficking protein particle complex 10
TRAPPC9 trafficking protein particle complex 9
TRIM27 tripartite motif containing 27
TRIM28 tripartite motif containing 28
TRIM32 tripartite motif containing 32
TRIM37 tripartite motif containing 37
UBB ubiquitin B
UBC ubiquitin C
USP11 ubiquitin specific peptidase 11
USP15 ubiquitin specific peptidase 15
USP54 ubiquitin specific peptidase 54
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAV1 vav 1 guanine nucleotide exchange factor
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR11 WD repeat domain 11
WDR12 WD repeat domain 12
WDR48 WD repeat domain 48
WDR6 WD repeat domain 6
WIZ widely interspaced zinc finger motifs
WWP1 WW domain containing E3 ubiquitin protein ligase 1
WWTR1 WW domain containing transcription regulator 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPO5 exportin 5
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YY1 YY1 transcription factor
ZBED4 zinc finger, BED-type containing 4
ZBTB2 zinc finger and BTB domain containing 2