NOTCH1 Gene Set

Dataset CHEA Transcription Factor Targets
Category genomics
Type transcription factor
Description notch 1|This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4851)
External Link http://www.ncbi.nlm.nih.gov/gene/4851
Similar Terms
Downloads & Tools

Genes

362 target genes of the NOTCH1 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

Symbol Name
AAMP angio-associated, migratory cell protein
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACAD8 acyl-CoA dehydrogenase family, member 8
ACP6 acid phosphatase 6, lysophosphatidic
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
ADAT2 adenosine deaminase, tRNA-specific 2
AEN apoptosis enhancing nuclease
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AJAP1 adherens junctions associated protein 1
AKIRIN2 akirin 2
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase
ALKBH2 alkB, alkylation repair homolog 2 (E. coli)
APCDD1 adenomatosis polyposis coli down-regulated 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL13B ADP-ribosylation factor-like 13B
ARL6 ADP-ribosylation factor-like 6
ATG4C autophagy related 4C, cysteine peptidase
ATP6AP1L ATPase, H+ transporting, lysosomal accessory protein 1-like
AVEN apoptosis, caspase activation inhibitor
BCHE butyrylcholinesterase
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
BMP4 bone morphogenetic protein 4
BRD8 bromodomain containing 8
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
BYSL bystin-like
C10ORF2 chromosome 10 open reading frame 2
C12ORF29 chromosome 12 open reading frame 29
C12ORF66 chromosome 12 open reading frame 66
C16ORF72 chromosome 16 open reading frame 72
C1ORF109 chromosome 1 open reading frame 109
C2ORF42 chromosome 2 open reading frame 42
CAPSL calcyphosine-like
CBR1 carbonyl reductase 1
CCDC90B coiled-coil domain containing 90B
CCT6P1 chaperonin containing TCP1, subunit 6 (zeta) pseudogene 1
CD244 CD244 molecule, natural killer cell receptor 2B4
CD27 CD27 molecule
CD300A CD300a molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDK5 cyclin-dependent kinase 5
CFL1 cofilin 1 (non-muscle)
CHI3L2 chitinase 3-like 2
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDND1 claudin domain containing 1
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CNOT4 CCR4-NOT transcription complex, subunit 4
COPS7B COP9 signalosome subunit 7B
COX7C cytochrome c oxidase subunit VIIc
CPA4 carboxypeptidase A4
CPE carboxypeptidase E
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSRNP2 cysteine-serine-rich nuclear protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXORF23 chromosome X open reading frame 23
CYB561D2 cytochrome b561 family, member D2
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIAS DNA damage-induced apoptosis suppressor
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DENND2D DENN/MADD domain containing 2D
DERL1 derlin 1
DET1 de-etiolated homolog 1 (Arabidopsis)
DGCR8 DGCR8 microprocessor complex subunit
DIEXF digestive organ expansion factor homolog (zebrafish)
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25
DTX1 deltex 1, E3 ubiquitin ligase
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
E2F6 E2F transcription factor 6
EARS2 glutamyl-tRNA synthetase 2, mitochondrial
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EN1 engrailed homeobox 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
EXOC8 exocyst complex component 8
FAM120AOS family with sequence similarity 120A opposite strand
FAM177A1 family with sequence similarity 177, member A1
FAM222B family with sequence similarity 222, member B
FAM96A family with sequence similarity 96, member A
FAS Fas cell surface death receptor
FEM1C fem-1 homolog c (C. elegans)
FGR FGR proto-oncogene, Src family tyrosine kinase
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FKRP fukutin related protein
FNTB farnesyltransferase, CAAX box, beta
FOCAD focadhesin
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FTL ferritin, light polypeptide
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FYCO1 FYVE and coiled-coil domain containing 1
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GFOD1 glucose-fructose oxidoreductase domain containing 1
GIMAP1 GTPase, IMAP family member 1
GIMAP2 GTPase, IMAP family member 2
GIMAP5 GTPase, IMAP family member 5
GIMAP6 GTPase, IMAP family member 6
GIMAP7 GTPase, IMAP family member 7
GMPR2 guanosine monophosphate reductase 2
GRK5 G protein-coupled receptor kinase 5
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GRWD1 glutamate-rich WD repeat containing 1
GSPT1 G1 to S phase transition 1
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HES1 hes family bHLH transcription factor 1
HES4 hes family bHLH transcription factor 4
HES5 hes family bHLH transcription factor 5
HPS6 Hermansky-Pudlak syndrome 6
HSPA13 heat shock protein 70kDa family, member 13
HSPH1 heat shock 105kDa/110kDa protein 1
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IFRD1 interferon-related developmental regulator 1
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IL21R interleukin 21 receptor
IL7R interleukin 7 receptor
ING3 inhibitor of growth family, member 3
INTS9 integrator complex subunit 9
INVS inversin
IPO4 importin 4
IRS2 insulin receptor substrate 2
IRX5 iroquois homeobox 5
JUN jun proto-oncogene
KBTBD6 kelch repeat and BTB (POZ) domain containing 6
KBTBD7 kelch repeat and BTB (POZ) domain containing 7
KCNK5 potassium channel, two pore domain subfamily K, member 5
KIF3A kinesin family member 3A
KIFAP3 kinesin-associated protein 3
KLHL21 kelch-like family member 21
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae)
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LAX1 lymphocyte transmembrane adaptor 1
LGMN legumain
LOC90784 uncharacterized LOC90784
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LTA4H leukotriene A4 hydrolase
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MARS2 methionyl-tRNA synthetase 2, mitochondrial
MDH1 malate dehydrogenase 1, NAD (soluble)
MED15 mediator complex subunit 15
MEPCE methylphosphate capping enzyme
METTL1 methyltransferase like 1
MGC16142 uncharacterized protein MGC16142
MIR155HG MIR155 host gene
MLKL mixed lineage kinase domain-like
MLYCD malonyl-CoA decarboxylase
MORC2-AS1 MORC2 antisense RNA 1
MRPL24 mitochondrial ribosomal protein L24
MRPS11 mitochondrial ribosomal protein S11
MRPS16 mitochondrial ribosomal protein S16
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MSANTD4 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NDC1 NDC1 transmembrane nucleoporin
NINJ1 ninjurin 1
NKIRAS1 NFKB inhibitor interacting Ras-like 1
NKX2-5 NK2 homeobox 5
NLE1 notchless homolog 1 (Drosophila)
NLGN4X neuroligin 4, X-linked
NOP14 NOP14 nucleolar protein
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUBP1 nucleotide binding protein 1
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
NUDT9P1 nudix (nucleoside diphosphate linked moiety X)-type motif 9 pseudogene 1
OSCAR osteoclast associated, immunoglobulin-like receptor
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative)
PCBP3 poly(rC) binding protein 3
PCDH19 protocadherin 19
PCGF5 polycomb group ring finger 5
PDE10A phosphodiesterase 10A
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PEMT phosphatidylethanolamine N-methyltransferase
PER2 period circadian clock 2
PEX12 peroxisomal biogenesis factor 12
PEX26 peroxisomal biogenesis factor 26
PFDN6 prefoldin subunit 6
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHB prohibitin
PHF6 PHD finger protein 6
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIGW phosphatidylinositol glycan anchor biosynthesis, class W
PLAGL2 pleiomorphic adenoma gene-like 2
PMEPA1 prostate transmembrane protein, androgen induced 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
POMT1 protein-O-mannosyltransferase 1
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRCC papillary renal cell carcinoma (translocation-associated)
PRKCA protein kinase C, alpha
PRPF31 pre-mRNA processing factor 31
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PTCRA pre T-cell antigen receptor alpha
PUS1 pseudouridylate synthase 1
PUS3 pseudouridylate synthase 3
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
R3HDM1 R3H domain containing 1
RANGAP1 Ran GTPase activating protein 1
RBL1 retinoblastoma-like 1
RBM6 RNA binding motif protein 6
RFESD Rieske (Fe-S) domain containing
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1
RNF111 ring finger protein 111
RNF144A ring finger protein 144A
RPL18A ribosomal protein L18a
RPPH1 ribonuclease P RNA component H1
RPS27L ribosomal protein S27-like
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
SALL3 spalt-like transcription factor 3
SCN7A sodium channel, voltage gated, type VII alpha subunit
SCNM1 sodium channel modifier 1
SEC11C SEC11 homolog C (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SENP8 SUMO/sentrin specific peptidase family member 8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SH2B2 SH2B adaptor protein 2
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SIRT1 sirtuin 1
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa
SNHG20 small nucleolar RNA host gene 20
SNHG3 small nucleolar RNA host gene 3
SNORD26 small nucleolar RNA, C/D box 26
SNORD42B small nucleolar RNA, C/D box 42B
SNORD60 small nucleolar RNA, C/D box 60
SNX1 sorting nexin 1
SOWAHA sosondowah ankyrin repeat domain family member A
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae)
SPHK2 sphingosine kinase 2
SPRYD4 SPRY domain containing 4
SRFBP1 serum response factor binding protein 1
STARD10 StAR-related lipid transfer (START) domain containing 10
STRIP2 striatin interacting protein 2
SYMPK symplekin
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TARBP2 TAR (HIV-1) RNA binding protein 2
TASP1 taspase, threonine aspartase, 1
TBCC tubulin folding cofactor C
TES testin LIM domain protein
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
THNSL1 threonine synthase-like 1 (S. cerevisiae)
THRAP3 thyroid hormone receptor associated protein 3
THYN1 thymocyte nuclear protein 1
TIGD1 tigger transposable element derived 1
TLE3 transducin-like enhancer of split 3
TMEM115 transmembrane protein 115
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM181 transmembrane protein 181
TMEM258 transmembrane protein 258
TMTC3 transmembrane and tetratricopeptide repeat containing 3
TNF tumor necrosis factor
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNRC6B trinucleotide repeat containing 6B
TRAPPC2P1
TRAPPC3 trafficking protein particle complex 3
TRIM39 tripartite motif containing 39
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TSNAXIP1 translin-associated factor X interacting protein 1
TUBB2A tubulin, beta 2A class IIa
TYSND1 trypsin domain containing 1
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VRK3 vaccinia related kinase 3
WDR47 WD repeat domain 47
YOD1 YOD1 deubiquitinase
ZBED8 zinc finger, BED-type containing 8
ZBTB6 zinc finger and BTB domain containing 6
ZBTB9 zinc finger and BTB domain containing 9
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZFP69 ZFP69 zinc finger protein
ZFP69B ZFP69 zinc finger protein B
ZFYVE19 zinc finger, FYVE domain containing 19
ZFYVE21 zinc finger, FYVE domain containing 21
ZMAT5 zinc finger, matrin-type 5
ZMYND11 zinc finger, MYND-type containing 11
ZNF10 zinc finger protein 10
ZNF12 zinc finger protein 12
ZNF133 zinc finger protein 133
ZNF134 zinc finger protein 134
ZNF14 zinc finger protein 14
ZNF155 zinc finger protein 155
ZNF200 zinc finger protein 200
ZNF202 zinc finger protein 202
ZNF225 zinc finger protein 225
ZNF226 zinc finger protein 226
ZNF239 zinc finger protein 239
ZNF24 zinc finger protein 24
ZNF256 zinc finger protein 256
ZNF260 zinc finger protein 260
ZNF263 zinc finger protein 263
ZNF275 zinc finger protein 275
ZNF304 zinc finger protein 304
ZNF317 zinc finger protein 317
ZNF324 zinc finger protein 324
ZNF331 zinc finger protein 331
ZNF337 zinc finger protein 337
ZNF354B zinc finger protein 354B
ZNF383 zinc finger protein 383
ZNF416 zinc finger protein 416
ZNF426 zinc finger protein 426
ZNF436 zinc finger protein 436
ZNF45 zinc finger protein 45
ZNF526 zinc finger protein 526
ZNF547 zinc finger protein 547
ZNF548 zinc finger protein 548
ZNF566 zinc finger protein 566
ZNF569 zinc finger protein 569
ZNF570 zinc finger protein 570
ZNF571 zinc finger protein 571
ZNF607 zinc finger protein 607
ZNF623 zinc finger protein 623
ZNF670 zinc finger protein 670
ZNF682 zinc finger protein 682
ZNF703 zinc finger protein 703
ZNF721 zinc finger protein 721
ZNF823 zinc finger protein 823
ZSCAN4 zinc finger and SCAN domain containing 4
ZSWIM3 zinc finger, SWIM-type containing 3
ZZZ3 zinc finger, ZZ-type containing 3