NK-92MI Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: IL-2 independent, cytotoxic to a wide range of malignant cells (Cell Line Ontology, CLO_0008178)
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373 genes mutated in the NK-92MI cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACOT9 acyl-CoA thioesterase 9
ACSS3 acyl-CoA synthetase short-chain family member 3
ACY3 aminoacylase 3
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16
ADGB androglobin
ADGRG3 adhesion G protein-coupled receptor G3
ADGRL2 adhesion G protein-coupled receptor L2
ADIG adipogenin
ADRBK2 adrenergic, beta, receptor kinase 2
AEBP1 AE binding protein 1
AFM afamin
AGBL4 ATP/GTP binding protein-like 4
AKAP13 A kinase (PRKA) anchor protein 13
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALPK1 alpha-kinase 1
ANKRD17 ankyrin repeat domain 17
ANKRD34B ankyrin repeat domain 34B
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B
ANO4 anoctamin 4
APOB apolipoprotein B
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP12B aquaporin 12B
AQP9 aquaporin 9
ARHGAP21 Rho GTPase activating protein 21
ARHGAP35 Rho GTPase activating protein 35
ARHGAP42 Rho GTPase activating protein 42
ASIC2 acid sensing (proton gated) ion channel 2
ATM ATM serine/threonine kinase
ATOH8 atonal homolog 8 (Drosophila)
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BAIAP2L1 BAI1-associated protein 2-like 1
BAIAP2L2 BAI1-associated protein 2-like 2
BBS10 Bardet-Biedl syndrome 10
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL7C B-cell CLL/lymphoma 7C
BCOR BCL6 corepressor
BEND5 BEN domain containing 5
BIN2 bridging integrator 2
BMP4 bone morphogenetic protein 4
C1R complement component 1, r subcomponent
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CASKIN2 CASK interacting protein 2
CASZ1 castor zinc finger 1
CCDC180 coiled-coil domain containing 180
CCDC33 coiled-coil domain containing 33
CCDC77 coiled-coil domain containing 77
CCDC81 coiled-coil domain containing 81
CCDC84 coiled-coil domain containing 84
CCKAR cholecystokinin A receptor
CCL16 chemokine (C-C motif) ligand 16
CCL3 chemokine (C-C motif) ligand 3
CCR9 chemokine (C-C motif) receptor 9
CD48 CD48 molecule
CENPF centromere protein F, 350/400kDa
CEP63 centrosomal protein 63kDa
CFHR4 complement factor H-related 4
CGN cingulin
CHD1 chromodomain helicase DNA binding protein 1
CHM choroideremia (Rab escort protein 1)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CIITA class II, major histocompatibility complex, transactivator
CIZ1 CDKN1A interacting zinc finger protein 1
CKAP5 cytoskeleton associated protein 5
CLDN17 claudin 17
CLTCL1 clathrin, heavy chain-like 1
CLU clusterin
CMYA5 cardiomyopathy associated 5
CNTNAP3B contactin associated protein-like 3B
COL12A1 collagen, type XII, alpha 1
COL1A2 collagen, type I, alpha 2
COL22A1 collagen, type XXII, alpha 1
COL4A4 collagen, type IV, alpha 4
COL5A3 collagen, type V, alpha 3
CORO2B coronin, actin binding protein, 2B
COX5B cytochrome c oxidase subunit Vb
CPSF3L cleavage and polyadenylation specific factor 3-like
CPT1B carnitine palmitoyltransferase 1B (muscle)
CREBBP CREB binding protein
CSMD3 CUB and Sushi multiple domains 3
CTSK cathepsin K
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
DCLRE1B DNA cross-link repair 1B
DENND1C DENN/MADD domain containing 1C
DENND2A DENN/MADD domain containing 2A
DGKZ diacylglycerol kinase, zeta
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAH1 dynein, axonemal, heavy chain 1
DNAH6 dynein, axonemal, heavy chain 6
DNAH7 dynein, axonemal, heavy chain 7
DPCR1 diffuse panbronchiolitis critical region 1
DSE dermatan sulfate epimerase
DST dystonin
DTX3L deltex 3 like, E3 ubiquitin ligase
DUOX2 dual oxidase 2
DVL3 dishevelled segment polarity protein 3
EFNB2 ephrin-B2
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3
EPB42 erythrocyte membrane protein band 4.2
EPHA3 EPH receptor A3
EPHA6 EPH receptor A6
ERO1L ERO1-like (S. cerevisiae)
EXOC3 exocyst complex component 3
FAM182B family with sequence similarity 182, member B
FAM189A2 family with sequence similarity 189, member A2
FAM193A family with sequence similarity 193, member A
FAM198B family with sequence similarity 198, member B
FAM24B family with sequence similarity 24, member B
FAM50A family with sequence similarity 50, member A
FANCM Fanconi anemia, complementation group M
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FBN3 fibrillin 3
FBXO38 F-box protein 38
FBXW8 F-box and WD repeat domain containing 8
FCHO2 FCH domain only 2
FGG fibrinogen gamma chain
FGGY FGGY carbohydrate kinase domain containing
FHOD1 formin homology 2 domain containing 1
FKBP6 FK506 binding protein 6, 36kDa
FLNB filamin B, beta
FOXC1 forkhead box C1
FRAS1 Fraser extracellular matrix complex subunit 1
FRG2 FSHD region gene 2
FSHR follicle stimulating hormone receptor
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GATA5 GATA binding protein 5
GEM GTP binding protein overexpressed in skeletal muscle
GIGYF1 GRB10 interacting GYF protein 1
GLI1 GLI family zinc finger 1
GLP1R glucagon-like peptide 1 receptor
GOLGA4 golgin A4
GOLM1 golgi membrane protein 1
GPATCH11 G patch domain containing 11
GRIK2 glutamate receptor, ionotropic, kainate 2
GRM1 glutamate receptor, metabotropic 1
GRM4 glutamate receptor, metabotropic 4
HDGFL1 hepatoma derived growth factor-like 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HHAT hedgehog acyltransferase
HINT1 histidine triad nucleotide binding protein 1
HIST1H3F histone cluster 1, H3f
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HSF1 heat shock transcription factor 1
IFITM5 interferon induced transmembrane protein 5
IL19 interleukin 19
IL2 interleukin 2
IL7R interleukin 7 receptor
IQCG IQ motif containing G
IQCJ IQ motif containing J
IRX1 iroquois homeobox 1
ITGAV integrin, alpha V
JPH3 junctophilin 3
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KIAA0430 KIAA0430
KIAA0754 KIAA0754
KIAA1671 KIAA1671
KMT2D lysine (K)-specific methyltransferase 2D
KRT85 keratin 85, type II
KRTAP5-10 keratin associated protein 5-10
KRTAP5-8 keratin associated protein 5-8
LAMA2 laminin, alpha 2
LAMA3 laminin, alpha 3
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LIMCH1 LIM and calponin homology domains 1
LOC541473 FK506 binding protein 6, 36kDa pseudogene
LPA lipoprotein, Lp(a)
LRP1 low density lipoprotein receptor-related protein 1
LRP1B low density lipoprotein receptor-related protein 1B
LRP2 low density lipoprotein receptor-related protein 2
LRRC41 leucine rich repeat containing 41
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LYNX1 Ly6/neurotoxin 1
MAGEC1 melanoma antigen family C1
MAGED1 melanoma antigen family D1
MAMLD1 mastermind-like domain containing 1
MAP2 microtubule-associated protein 2
MAPK7 mitogen-activated protein kinase 7
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
METTL1 methyltransferase like 1
MGAM maltase-glucoamylase
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MPEG1 macrophage expressed 1
MROH2B maestro heat-like repeat family member 2B
MUC19 mucin 19, oligomeric
MUC4 mucin 4, cell surface associated
MUC6 mucin 6, oligomeric mucus/gel-forming
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYO18A myosin XVIIIA
MYO1E myosin IE
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1
NANOG Nanog homeobox
NAV2 neuron navigator 2
NCAPG2 non-SMC condensin II complex, subunit G2
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
NES nestin
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1
NEXN nexilin (F actin binding protein)
NFIL3 nuclear factor, interleukin 3 regulated
NGEF neuronal guanine nucleotide exchange factor
NGFR nerve growth factor receptor
NLRP12 NLR family, pyrin domain containing 12
NOVA2 neuro-oncological ventral antigen 2
NRF1 nuclear respiratory factor 1
NRIP2 nuclear receptor interacting protein 2
NXPE2 neurexophilin and PC-esterase domain family, member 2
NXPE4 neurexophilin and PC-esterase domain family, member 4
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OR1M1 olfactory receptor, family 1, subfamily M, member 1
OR2L8 olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)
OR2T3 olfactory receptor, family 2, subfamily T, member 3
OR52A1 olfactory receptor, family 52, subfamily A, member 1
OR5D14 olfactory receptor, family 5, subfamily D, member 14
OR5L1 olfactory receptor, family 5, subfamily L, member 1 (gene/pseudogene)
OR6C65 olfactory receptor, family 6, subfamily C, member 65
ORC5 origin recognition complex, subunit 5
ORM1 orosomucoid 1
OTUD7B OTU deubiquitinase 7B
PABPC1 poly(A) binding protein, cytoplasmic 1
PAIP1 poly(A) binding protein interacting protein 1
PAX3 paired box 3
PCDHA1 protocadherin alpha 1
PCDHA7 protocadherin alpha 7
PCDHB1 protocadherin beta 1
PCLO piccolo presynaptic cytomatrix protein
PCM1 pericentriolar material 1
PGBD4 piggyBac transposable element derived 4
PHF20L1 PHD finger protein 20-like 1
PHF3 PHD finger protein 3
PHIP pleckstrin homology domain interacting protein
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PIDD1 p53-induced death domain protein 1
PIGX phosphatidylinositol glycan anchor biosynthesis, class X
PKDREJ polycystin (PKD) family receptor for egg jelly
PKNOX1 PBX/knotted 1 homeobox 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLTP phospholipid transfer protein
PLXNA1 plexin A1
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
PPHLN1 periphilin 1
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP6R2 protein phosphatase 6, regulatory subunit 2
PRB4 proline-rich protein BstNI subfamily 4
PRDM1 PR domain containing 1, with ZNF domain
PRDX5 peroxiredoxin 5
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
PROP1 PROP paired-like homeobox 1
PSG6 pregnancy specific beta-1-glycoprotein 6
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PURG purine-rich element binding protein G
PYGL phosphorylase, glycogen, liver
RAB29 RAB29, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RANBP2 RAN binding protein 2
RAP1B RAP1B, member of RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RASSF3 Ras association (RalGDS/AF-6) domain family member 3
RBM12B RNA binding motif protein 12B
RBMXL3 RNA binding motif protein, X-linked-like 3
RELN reelin
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFTN1 raftlin, lipid raft linker 1
RHOJ ras homolog family member J
RIF1 replication timing regulatory factor 1
RIMKLA ribosomal modification protein rimK-like family member A
RIN2 Ras and Rab interactor 2
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae)
RNF213 ring finger protein 213
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RPS6KL1 ribosomal protein S6 kinase-like 1
RTL1 retrotransposon-like 1
SASS6 spindle assembly 6 homolog (C. elegans)
SATB1 SATB homeobox 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SEC24D SEC24 family member D
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SESTD1 SEC14 and spectrin domains 1
SETD4 SET domain containing 4
SGK2 serum/glucocorticoid regulated kinase 2
SH3RF1 SH3 domain containing ring finger 1
SIRT3 sirtuin 3
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC25A46 solute carrier family 25, member 46
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMC3 structural maintenance of chromosomes 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNRK SNF related kinase
SOAT2 sterol O-acyltransferase 2
SOWAHB sosondowah ankyrin repeat domain family member B
SOX6 SRY (sex determining region Y)-box 6
SP2 Sp2 transcription factor
SPAG17 sperm associated antigen 17
SPICE1 spindle and centriole associated protein 1
SPRR1B small proline-rich protein 1B
SPTBN4 spectrin, beta, non-erythrocytic 4
SRCAP Snf2-related CREBBP activator protein
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)
STRADA STE20-related kinase adaptor alpha
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
TACC2 transforming, acidic coiled-coil containing protein 2
TAPT1 transmembrane anterior posterior transformation 1
TBC1D22B TBC1 domain family, member 22B
TCP10L2 t-complex 10-like 2
TECPR2 tectonin beta-propeller repeat containing 2
TEX15 testis expressed 15
THBD thrombomodulin
THSD7B thrombospondin, type I, domain containing 7B
TIMP2 TIMP metallopeptidase inhibitor 2
TLN2 talin 2
TLR4 toll-like receptor 4
TMEM2 transmembrane protein 2
TNK2 tyrosine kinase, non-receptor, 2
TP53 tumor protein p53
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRERF1 transcriptional regulating factor 1
TRIM58 tripartite motif containing 58
TRIM64B tripartite motif containing 64B
TRIM69 tripartite motif containing 69
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TSPAN33 tetraspanin 33
TTC28 tetratricopeptide repeat domain 28
TTLL4 tubulin tyrosine ligase-like family member 4
TTN titin
TUBE1 tubulin, epsilon 1
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UIMC1 ubiquitin interaction motif containing 1
USH2A Usher syndrome 2A (autosomal recessive, mild)
USP43 ubiquitin specific peptidase 43
UTRN utrophin
UXT ubiquitously-expressed, prefoldin-like chaperone
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
VTN vitronectin
WDR17 WD repeat domain 17
WDR43 WD repeat domain 43
WDR86 WD repeat domain 86
WWC3 WWC family member 3
ZACN zinc activated ligand-gated ion channel
ZBTB41 zinc finger and BTB domain containing 41
ZMYND8 zinc finger, MYND-type containing 8
ZNF100 zinc finger protein 100
ZNF135 zinc finger protein 135
ZNF142 zinc finger protein 142
ZNF212 zinc finger protein 212
ZNF256 zinc finger protein 256
ZNF292 zinc finger protein 292
ZNF343 zinc finger protein 343
ZNF358 zinc finger protein 358
ZNF441 zinc finger protein 441
ZNF483 zinc finger protein 483
ZNF546 zinc finger protein 546
ZNF600 zinc finger protein 600
ZNF721 zinc finger protein 721