NCI-N417 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Small cell lung cancer cell line. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003028)
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Genes

184 genes mutated in the NCI-N417 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
AKAP1 A kinase (PRKA) anchor protein 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDOC aldolase C, fructose-bisphosphate
ALG10 ALG10, alpha-1,2-glucosyltransferase
ANKRD17 ankyrin repeat domain 17
ANKRD6 ankyrin repeat domain 6
APC2 adenomatosis polyposis coli 2
ARHGAP5 Rho GTPase activating protein 5
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATAD3B ATPase family, AAA domain containing 3B
ATRX alpha thalassemia/mental retardation syndrome X-linked
AURKB aurora kinase B
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BIRC6 baculoviral IAP repeat containing 6
BOC BOC cell adhesion associated, oncogene regulated
BOP1 block of proliferation 1
CAND1 cullin-associated and neddylation-dissociated 1
CASP8AP2 caspase 8 associated protein 2
CCDC62 coiled-coil domain containing 62
CCM2 cerebral cavernous malformation 2
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNE1 cyclin E1
CEP85 centrosomal protein 85kDa
CFAP61 cilia and flagella associated protein 61
CPSF3L cleavage and polyadenylation specific factor 3-like
CTNND2 catenin (cadherin-associated protein), delta 2
CYB561 cytochrome b561
CYB5R4 cytochrome b5 reductase 4
DBT dihydrolipoamide branched chain transacylase E2
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DIDO1 death inducer-obliterator 1
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK6 docking protein 6
DPYSL3 dihydropyrimidinase-like 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENO1 enolase 1, (alpha)
EPC2 enhancer of polycomb homolog 2 (Drosophila)
FAM13B family with sequence similarity 13, member B
FASTKD3 FAST kinase domains 3
FBRSL1 fibrosin-like 1
FLNB filamin B, beta
FSD1L fibronectin type III and SPRY domain containing 1-like
GPR1 G protein-coupled receptor 1
HDAC9 histone deacetylase 9
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
HKR1 HKR1, GLI-Kruppel zinc finger family member
HNRNPF heterogeneous nuclear ribonucleoprotein F
HOXA3 homeobox A3
ICAM5 intercellular adhesion molecule 5, telencephalin
IGSF8 immunoglobulin superfamily, member 8
IRAK4 interleukin-1 receptor-associated kinase 4
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAK2 Janus kinase 2
JARID2 jumonji, AT rich interactive domain 2
KANK2 KN motif and ankyrin repeat domains 2
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KIAA0196 KIAA0196
KIAA1328 KIAA1328
KIF1A kinesin family member 1A
KIRREL kin of IRRE like (Drosophila)
KLHL17 kelch-like family member 17
KMT2C lysine (K)-specific methyltransferase 2C
KMT2D lysine (K)-specific methyltransferase 2D
LAMB1 laminin, beta 1
LHX1 LIM homeobox 1
LRFN5 leucine rich repeat and fibronectin type III domain containing 5
LRP3 low density lipoprotein receptor-related protein 3
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LRRC8D leucine rich repeat containing 8 family, member D
LSM11 LSM11, U7 small nuclear RNA associated
LUM lumican
MAP2 microtubule-associated protein 2
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPT microtubule-associated protein tau
MFSD3 major facilitator superfamily domain containing 3
MIA3 melanoma inhibitory activity family, member 3
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MIS12 MIS12 kinetochore complex component
MKI67 marker of proliferation Ki-67
MROH8 maestro heat-like repeat family member 8
MRPL44 mitochondrial ribosomal protein L44
MSH2 mutS homolog 2
MTUS1 microtubule associated tumor suppressor 1
MXRA8 matrix-remodelling associated 8
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYLK3 myosin light chain kinase 3
MYO19 myosin XIX
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit
NAV3 neuron navigator 3
NBEAL2 neurobeachin-like 2
NCAM2 neural cell adhesion molecule 2
NES nestin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUP35 nucleoporin 35kDa
NUP37 nucleoporin 37kDa
OXCT1 3-oxoacid CoA transferase 1
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDE4C phosphodiesterase 4C, cAMP-specific
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEX19 peroxisomal biogenesis factor 19
PHF3 PHD finger protein 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKNOX1 PBX/knotted 1 homeobox 1
PLEKHA7 pleckstrin homology domain containing, family A member 7
PNPLA6 patatin-like phospholipase domain containing 6
PRDM15 PR domain containing 15
PRDX4 peroxiredoxin 4
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF3 pre-mRNA processing factor 3
PRPF4B pre-mRNA processing factor 4B
PRSS41 protease, serine, 41
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PTPRS protein tyrosine phosphatase, receptor type, S
PTX3 pentraxin 3, long
RAD51D RAD51 paralog D
RHOC ras homolog family member C
RHOG ras homolog family member G
RHPN1 rhophilin, Rho GTPase binding protein 1
RIMBP2 RIMS binding protein 2
RNF213 ring finger protein 213
RPIA ribose 5-phosphate isomerase A
RSL24D1 ribosomal L24 domain containing 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAPCD1 suppressor APC domain containing 1
SARNP SAP domain containing ribonucleoprotein
SASH1 SAM and SH3 domain containing 1
SBNO1 strawberry notch homolog 1 (Drosophila)
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SEZ6 seizure related 6 homolog (mouse)
SFT2D3 SFT2 domain containing 3
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2
SLIT2 slit homolog 2 (Drosophila)
SNX17 sorting nexin 17
SP1 Sp1 transcription factor
SRCAP Snf2-related CREBBP activator protein
SRFBP1 serum response factor binding protein 1
ST18 suppression of tumorigenicity 18, zinc finger
ST7 suppression of tumorigenicity 7
SYTL1 synaptotagmin-like 1
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D32 TBC1 domain family, member 32
TBCD tubulin folding cofactor D
TBX20 T-box 20
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2
TENM1 teneurin transmembrane protein 1
TEX15 testis expressed 15
TEX30 testis expressed 30
TFB1M transcription factor B1, mitochondrial
TGFB3 transforming growth factor, beta 3
TLE2 transducin-like enhancer of split 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TNRC6C trinucleotide repeat containing 6C
TP53 tumor protein p53
TRAK2 trafficking protein, kinesin binding 2
TRIB1 tribbles pseudokinase 1
TRIM56 tripartite motif containing 56
TRIO trio Rho guanine nucleotide exchange factor
TTC3 tetratricopeptide repeat domain 3
TXNDC17 thioredoxin domain containing 17
UBE3B ubiquitin protein ligase E3B
VANGL1 VANGL planar cell polarity protein 1
WASF3 WAS protein family, member 3
WDR12 WD repeat domain 12
WDR70 WD repeat domain 70
ZDBF2 zinc finger, DBF-type containing 2
ZDHHC11 zinc finger, DHHC-type containing 11
ZEB2 zinc finger E-box binding homeobox 2
ZFHX4 zinc finger homeobox 4
ZFP64 ZFP64 zinc finger protein
ZMYM3 zinc finger, MYM-type 3
ZNF235 zinc finger protein 235
ZNF518B zinc finger protein 518B
ZNF585A zinc finger protein 585A
ZNF614 zinc finger protein 614
ZNF629 zinc finger protein 629
ZNF746 zinc finger protein 746