NCI-H920 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: adenocarcinoma; non-small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008126)
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Genes

405 genes mutated in the NCI-H920 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABLIM1 actin binding LIM protein 1
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16
ADCY8 adenylate cyclase 8 (brain)
ADGRB1 adhesion G protein-coupled receptor B1
ADGRL1 adhesion G protein-coupled receptor L1
AGFG2 ArfGAP with FG repeats 2
AGRN agrin
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AIM1L absent in melanoma 1-like
AKR1C3 aldo-keto reductase family 1, member C3
AKR1C4 aldo-keto reductase family 1, member C4
ALMS1 Alstrom syndrome protein 1
ALOX5 arachidonate 5-lipoxygenase
ANAPC1 anaphase promoting complex subunit 1
ANGEL1 angel homolog 1 (Drosophila)
ANKRD17 ankyrin repeat domain 17
ANKRD26 ankyrin repeat domain 26
ANKRD35 ankyrin repeat domain 35
ANKRD42 ankyrin repeat domain 42
ANKRD9 ankyrin repeat domain 9
AP3M2 adaptor-related protein complex 3, mu 2 subunit
ARPC5L actin related protein 2/3 complex, subunit 5-like
ASXL1 additional sex combs like transcriptional regulator 1
ASXL2 additional sex combs like transcriptional regulator 2
ATG4A autophagy related 4A, cysteine peptidase
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATXN1 ataxin 1
ATXN3 ataxin 3
BBS1 Bardet-Biedl syndrome 1
BCL9L B-cell CLL/lymphoma 9-like
BCOR BCL6 corepressor
BLK BLK proto-oncogene, Src family tyrosine kinase
BLM Bloom syndrome, RecQ helicase-like
BRD9 bromodomain containing 9
BTBD11 BTB (POZ) domain containing 11
BTBD3 BTB (POZ) domain containing 3
BTD biotinidase
C10ORF12 chromosome 10 open reading frame 12
C5ORF42 chromosome 5 open reading frame 42
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CALB2 calbindin 2
CARD6 caspase recruitment domain family, member 6
CASP8AP2 caspase 8 associated protein 2
CCDC150 coiled-coil domain containing 150
CCDC88A coiled-coil domain containing 88A
CCDC88C coiled-coil domain containing 88C
CCNT2 cyclin T2
CCSER2 coiled-coil serine-rich protein 2
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD109 CD109 molecule
CD93 CD93 molecule
CDAN1 codanin 1
CDC7 cell division cycle 7
CDCA2 cell division cycle associated 2
CDCA3 cell division cycle associated 3
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CENPF centromere protein F, 350/400kDa
CEP70 centrosomal protein 70kDa
CERCAM cerebral endothelial cell adhesion molecule
CFAP44 cilia and flagella associated protein 44
CGNL1 cingulin-like 1
CHD3 chromodomain helicase DNA binding protein 3
CHD6 chromodomain helicase DNA binding protein 6
CHIC1 cysteine-rich hydrophobic domain 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLK1 CDC-like kinase 1
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CLSTN1 calsyntenin 1
CNRIP1 cannabinoid receptor interacting protein 1
CNST consortin, connexin sorting protein
CNTFR ciliary neurotrophic factor receptor
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A2 collagen, type IV, alpha 2
COQ4 coenzyme Q4
CPPED1 calcineurin-like phosphoesterase domain containing 1
CREBBP CREB binding protein
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTBP1 C-terminal binding protein 1
CTBS chitobiase, di-N-acetyl-
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTSZ cathepsin Z
CXORF23 chromosome X open reading frame 23
CYB5R4 cytochrome b5 reductase 4
CYR61 cysteine-rich, angiogenic inducer, 61
D2HGDH D-2-hydroxyglutarate dehydrogenase
DAB2IP DAB2 interacting protein
DAGLA diacylglycerol lipase, alpha
DCAF4L2 DDB1 and CUL4 associated factor 4-like 2
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DENND1A DENN/MADD domain containing 1A
DERL3 derlin 3
DGKI diacylglycerol kinase, iota
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila)
DMXL2 Dmx-like 2
DNAH2 dynein, axonemal, heavy chain 2
DOCK7 dedicator of cytokinesis 7
DPY19L4 dpy-19-like 4 (C. elegans)
DPYD dihydropyrimidine dehydrogenase
DSE dermatan sulfate epimerase
DST dystonin
DUSP23 dual specificity phosphatase 23
DUSP6 dual specificity phosphatase 6
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E4F1 E4F transcription factor 1
EFCAB13 EF-hand calcium binding domain 13
EFR3A EFR3 homolog A (S. cerevisiae)
EHBP1 EH domain binding protein 1
EML3 echinoderm microtubule associated protein like 3
EMP2 epithelial membrane protein 2
ENGASE endo-beta-N-acetylglucosaminidase
ENOSF1 enolase superfamily member 1
EP400 E1A binding protein p400
EPRS glutamyl-prolyl-tRNA synthetase
EPS8L1 EPS8-like 1
ERCC2 excision repair cross-complementation group 2
EXOSC2 exosome component 2
EXOSC6 exosome component 6
EXPH5 exophilin 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129B family with sequence similarity 129, member B
FAM135A family with sequence similarity 135, member A
FAM167A family with sequence similarity 167, member A
FAM171B family with sequence similarity 171, member B
FAM179B family with sequence similarity 179, member B
FAM189B family with sequence similarity 189, member B
FAM207A family with sequence similarity 207, member A
FAM81A family with sequence similarity 81, member A
FAR1 fatty acyl CoA reductase 1
FAT4 FAT atypical cadherin 4
FBN1 fibrillin 1
FBXL4 F-box and leucine-rich repeat protein 4
FBXO18 F-box protein, helicase, 18
FBXO4 F-box protein 4
FBXW8 F-box and WD repeat domain containing 8
FDX1 ferredoxin 1
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1
FKRP fukutin related protein
FLNA filamin A, alpha
FMR1 fragile X mental retardation 1
FOCAD focadhesin
FOXK2 forkhead box K2
GALK2 galactokinase 2
GAP43 growth associated protein 43
GBA2 glucosidase, beta (bile acid) 2
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GGT5 gamma-glutamyltransferase 5
GLB1 galactosidase, beta 1
GLDC glycine dehydrogenase (decarboxylating)
GLRB glycine receptor, beta
GPATCH2 G patch domain containing 2
GPR63 G protein-coupled receptor 63
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HCFC2 host cell factor C2
HDLBP high density lipoprotein binding protein
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HES7 hes family bHLH transcription factor 7
HHIPL2 HHIP-like 2
HK1 hexokinase 1
HSPA1A heat shock 70kDa protein 1A
HSPG2 heparan sulfate proteoglycan 2
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IFFO1 intermediate filament family orphan 1
IFT27 intraflagellar transport 27
IFT57 intraflagellar transport 57
IFT88 intraflagellar transport 88
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1
IL17RA interleukin 17 receptor A
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INTU inturned planar cell polarity protein
IRAK1 interleukin-1 receptor-associated kinase 1
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGB8 integrin, beta 8
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JARID2 jumonji, AT rich interactive domain 2
KANK1 KN motif and ankyrin repeat domains 1
KAT6B K(lysine) acetyltransferase 6B
KAT7 K(lysine) acetyltransferase 7
KAT8 K(lysine) acetyltransferase 8
KBTBD3 kelch repeat and BTB (POZ) domain containing 3
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KCNJ18 potassium channel, inwardly rectifying subfamily J, member 18
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1
KCTD3 potassium channel tetramerization domain containing 3
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KIF21A kinesin family member 21A
KLHL11 kelch-like family member 11
KNTC1 kinetochore associated 1
LAMB3 laminin, beta 3
LMAN1 lectin, mannose-binding, 1
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3
LRP1 low density lipoprotein receptor-related protein 1
LRRC8B leucine rich repeat containing 8 family, member B
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LSG1 large 60S subunit nuclear export GTPase 1
LUM lumican
LYAR Ly1 antibody reactive
LZTR1 leucine-zipper-like transcription regulator 1
MACF1 microtubule-actin crosslinking factor 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP9 microtubule-associated protein 9
MARC2 mitochondrial amidoxime reducing component 2
MARS methionyl-tRNA synthetase
MCM9 minichromosome maintenance complex component 9
MDM4 MDM4, p53 regulator
MIDN midnolin
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MON1B MON1 secretory trafficking family member B
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MSX1 msh homeobox 1
MTDH metadherin
MTMR3 myotubularin related protein 3
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MUC16 mucin 16, cell surface associated
MUTYH mutY homolog
MYBPH myosin binding protein H
MYO16 myosin XVI
MYO7A myosin VIIA
NALCN sodium leak channel, non selective
NAV1 neuron navigator 1
NBEA neurobeachin
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NCKAP1 NCK-associated protein 1
NCOR2 nuclear receptor corepressor 2
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NFE2L1 nuclear factor, erythroid 2-like 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NINL ninein-like
NISCH nischarin
NLRP1 NLR family, pyrin domain containing 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5DC1 5'-nucleotidase domain containing 1
NUP107 nucleoporin 107kDa
NUP188 nucleoporin 188kDa
OLFML2B olfactomedin-like 2B
ONECUT2 one cut homeobox 2
ORC1 origin recognition complex, subunit 1
OTUD1 OTU deubiquitinase 1
PAM peptidylglycine alpha-amidating monooxygenase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP14 poly (ADP-ribose) polymerase family, member 14
PARP4 poly (ADP-ribose) polymerase family, member 4
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCSK9 proprotein convertase subtilisin/kexin type 9
PCYOX1 prenylcysteine oxidase 1
PDCD7 programmed cell death 7
PEG10 paternally expressed 10
PELI3 pellino E3 ubiquitin protein ligase family member 3
PEX1 peroxisomal biogenesis factor 1
PHEX phosphate regulating endopeptidase homolog, X-linked
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
PLEKHN1 pleckstrin homology domain containing, family N member 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POGLUT1 protein O-glucosyltransferase 1
POLM polymerase (DNA directed), mu
PPA2 pyrophosphatase (inorganic) 2
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
PRRC2A proline-rich coiled-coil 2A
PRSS41 protease, serine, 41
PTPRB protein tyrosine phosphatase, receptor type, B
PYGO2 pygopus family PHD finger 2
QPRT quinolinate phosphoribosyltransferase
QSOX2 quiescin Q6 sulfhydryl oxidase 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB4B RAB4B, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAI1 retinoic acid induced 1
RANBP2 RAN binding protein 2
RBM23 RNA binding motif protein 23
RBM33 RNA binding motif protein 33
RBM34 RNA binding motif protein 34
RECQL4 RecQ protein-like 4
RET ret proto-oncogene
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RIPK2 receptor-interacting serine-threonine kinase 2
RITA1 RBPJ interacting and tubulin associated 1
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
RNF185 ring finger protein 185
RNPEP arginyl aminopeptidase (aminopeptidase B)
RPAP1 RNA polymerase II associated protein 1
S100PBP S100P binding protein
S1PR1 sphingosine-1-phosphate receptor 1
SACS sacsin molecular chaperone
SCAF1 SR-related CTD-associated factor 1
SCEL sciellin
SDR42E1 short chain dehydrogenase/reductase family 42E, member 1
SEC16A SEC16 homolog A (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
SH3BP5L SH3-binding domain protein 5-like
SIK3 SIK family kinase 3
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A46 solute carrier family 25, member 46
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SLIT2 slit homolog 2 (Drosophila)
SLITRK6 SLIT and NTRK-like family, member 6
SNAP91 synaptosomal-associated protein, 91kDa
SOAT1 sterol O-acyltransferase 1
SOGA3 SOGA family member 3
SP100 SP100 nuclear antigen
SPTB spectrin, beta, erythrocytic
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STARD7 StAR-related lipid transfer (START) domain containing 7
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STOML1 stomatin (EPB72)-like 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYMPK symplekin
SZT2 seizure threshold 2 homolog (mouse)
TASP1 taspase, threonine aspartase, 1
TBC1D2B TBC1 domain family, member 2B
THEMIS2 thymocyte selection associated family member 2
THSD7A thrombospondin, type I, domain containing 7A
TIMELESS timeless circadian clock
TLN1 talin 1
TMEM180 transmembrane protein 180
TMEM231 transmembrane protein 231
TMEM259 transmembrane protein 259
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNRC6C trinucleotide repeat containing 6C
TPST1 tyrosylprotein sulfotransferase 1
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TREML4 triggering receptor expressed on myeloid cells-like 4
TRHDE thyrotropin-releasing hormone degrading enzyme
TRIM37 tripartite motif containing 37
TRIM56 tripartite motif containing 56
TRIM7 tripartite motif containing 7
TRIP13 thyroid hormone receptor interactor 13
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TROVE2 TROVE domain family, member 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRRAP transformation/transcription domain-associated protein
TSSC1 tumor suppressing subtransferable candidate 1
TTC19 tetratricopeptide repeat domain 19
TTLL6 tubulin tyrosine ligase-like family member 6
UBA2 ubiquitin-like modifier activating enzyme 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UBE4B ubiquitination factor E4B
UBR4 ubiquitin protein ligase E3 component n-recognin 4
USF1 upstream transcription factor 1
USP2 ubiquitin specific peptidase 2
USP25 ubiquitin specific peptidase 25
USP31 ubiquitin specific peptidase 31
USP38 ubiquitin specific peptidase 38
USP53 ubiquitin specific peptidase 53
UTRN utrophin
VAT1 vesicle amine transport 1
VEGFC vascular endothelial growth factor C
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A
WDHD1 WD repeat and HMG-box DNA binding protein 1
WDR25 WD repeat domain 25
WDR3 WD repeat domain 3
WDR5 WD repeat domain 5
WDR7 WD repeat domain 7
WHSC1 Wolf-Hirschhorn syndrome candidate 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XIRP2 xin actin binding repeat containing 2
YAF2 YY1 associated factor 2
ZBED6 zinc finger, BED-type containing 6
ZBTB7A zinc finger and BTB domain containing 7A
ZDHHC9 zinc finger, DHHC-type containing 9
ZEB2 zinc finger E-box binding homeobox 2
ZFYVE9 zinc finger, FYVE domain containing 9
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF236 zinc finger protein 236
ZNF25 zinc finger protein 25
ZNF33B zinc finger protein 33B
ZNF37A zinc finger protein 37A
ZNF432 zinc finger protein 432
ZNF461 zinc finger protein 461
ZNF462 zinc finger protein 462
ZNF518A zinc finger protein 518A
ZNF568 zinc finger protein 568
ZNF573 zinc finger protein 573
ZNF598 zinc finger protein 598
ZNF608 zinc finger protein 608
ZNF746 zinc finger protein 746
ZNF850 zinc finger protein 850
ZSCAN5A zinc finger and SCAN domain containing 5A