NCI-H889 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Human small cell lung cancer cell line, established from a 69 years old caucasian female, derived from the lymph node, stage E carcinoma. (BRENDA Tissue and Enzyme Source Ontology, BTO_0005667)
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Genes

121 genes mutated in the NCI-H889 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
AATK apoptosis-associated tyrosine kinase
AHNAK AHNAK nucleoprotein
ALDOC aldolase C, fructose-bisphosphate
BCL9 B-cell CLL/lymphoma 9
C3ORF58 chromosome 3 open reading frame 58
C3ORF62 chromosome 3 open reading frame 62
CADM2 cell adhesion molecule 2
CADPS Ca++-dependent secretion activator
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CNTD2 cyclin N-terminal domain containing 2
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1
CSMD1 CUB and Sushi multiple domains 1
CTNNA2 catenin (cadherin-associated protein), alpha 2
CYLD cylindromatosis (turban tumor syndrome)
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAAF3 dynein, axonemal, assembly factor 3
ENOSF1 enolase superfamily member 1
EP400 E1A binding protein p400
EPN1 epsin 1
ESRP1 epithelial splicing regulatory protein 1
FAM122A family with sequence similarity 122A
FANCF Fanconi anemia, complementation group F
FBXL12 F-box and leucine-rich repeat protein 12
FBXO7 F-box protein 7
FCGBP Fc fragment of IgG binding protein
FOXA3 forkhead box A3
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1
GCC2 GRIP and coiled-coil domain containing 2
GREB1 growth regulation by estrogen in breast cancer 1
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSPA1L heat shock 70kDa protein 1-like
IGSF10 immunoglobulin superfamily, member 10
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INADL InaD-like (Drosophila)
INCENP inner centromere protein antigens 135/155kDa
INHBB inhibin, beta B
IPO11 importin 11
IRF2BPL interferon regulatory factor 2 binding protein-like
IRGQ immunity-related GTPase family, Q
KIF1C kinesin family member 1C
KIF26A kinesin family member 26A
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL23 kelch-like family member 23
LAMC2 laminin, gamma 2
LARP6 La ribonucleoprotein domain family, member 6
LDLRAD3 low density lipoprotein receptor class A domain containing 3
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MBD2 methyl-CpG binding domain protein 2
MFN2 mitofusin 2
MIDN midnolin
NARF nuclear prelamin A recognition factor
NCALD neurocalcin delta
NKX3-1 NK3 homeobox 1
NRIP3 nuclear receptor interacting protein 3
NRXN1 neurexin 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NSUN6 NOP2/Sun domain family, member 6
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
ORAI1 ORAI calcium release-activated calcium modulator 1
OSBP oxysterol binding protein
P3H3 prolyl 3-hydroxylase 3
PAGE2 P antigen family, member 2 (prostate associated)
PAXBP1 PAX3 and PAX7 binding protein 1
PCNXL2 pecanex-like 2 (Drosophila)
PES1 pescadillo ribosomal biogenesis factor 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHF2 PHD finger protein 2
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough
POR P450 (cytochrome) oxidoreductase
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRMT9 protein arginine methyltransferase 9
PRR15L proline rich 15-like
PTDSS2 phosphatidylserine synthase 2
PTPRJ protein tyrosine phosphatase, receptor type, J
PVRIG poliovirus receptor related immunoglobulin domain containing
RARS2 arginyl-tRNA synthetase 2, mitochondrial
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RGL4 ral guanine nucleotide dissociation stimulator-like 4
RIC1 RAB6A GEF complex partner 1
RPAP1 RNA polymerase II associated protein 1
S100A10 S100 calcium binding protein A10
SCAPER S-phase cyclin A-associated protein in the ER
SDC1 syndecan 1
SEC11C SEC11 homolog C (S. cerevisiae)
SETX senataxin
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SHC4 SHC (Src homology 2 domain containing) family, member 4
SIK3 SIK family kinase 3
SIN3B SIN3 transcription regulator family member B
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A40 solute carrier family 25, member 40
SLC35E2B solute carrier family 35, member E2B
SLIT2 slit homolog 2 (Drosophila)
SPATA13 spermatogenesis associated 13
SPATA17 spermatogenesis associated 17
TECPR1 tectonin beta-propeller repeat containing 1
TMEM185B transmembrane protein 185B
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOP3A topoisomerase (DNA) III alpha
TOX thymocyte selection-associated high mobility group box
TP53 tumor protein p53
TSPYL5 TSPY-like 5
UIMC1 ubiquitin interaction motif containing 1
UNC13B unc-13 homolog B (C. elegans)
WARS tryptophanyl-tRNA synthetase
WRAP73 WD repeat containing, antisense to TP73
ZBTB21 zinc finger and BTB domain containing 21
ZNF211 zinc finger protein 211
ZNF292 zinc finger protein 292
ZNF521 zinc finger protein 521
ZNF589 zinc finger protein 589
ZNF689 zinc finger protein 689
ZNF699 zinc finger protein 699
ZNF717 zinc finger protein 717
ZNF74 zinc finger protein 74