NCI-H841 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: carcinoma; variant small cell lung cancer (lung primary) (Cell Line Ontology, CLO_0008122)
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Genes

405 genes mutated in the NCI-H841 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
ACHE acetylcholinesterase (Yt blood group)
ACIN1 apoptotic chromatin condensation inducer 1
ACTG1 actin gamma 1
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8
ADAMTSL2 ADAMTS-like 2
ADGB androglobin
ADGRA1 adhesion G protein-coupled receptor A1
ADGRF2 adhesion G protein-coupled receptor F2
ADGRV1 adhesion G protein-coupled receptor V1
ADPRHL1 ADP-ribosylhydrolase like 1
AFF1 AF4/FMR2 family, member 1
AHSG alpha-2-HS-glycoprotein
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH16A1 aldehyde dehydrogenase 16 family, member A1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANKRD36 ankyrin repeat domain 36
ANO5 anoctamin 5
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
AQP7 aquaporin 7
ARHGAP22 Rho GTPase activating protein 22
ARHGAP32 Rho GTPase activating protein 32
ARHGAP6 Rho GTPase activating protein 6
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25
ARID1A AT rich interactive domain 1A (SWI-like)
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASPN asporin
ATAD2 ATPase family, AAA domain containing 2
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATRX alpha thalassemia/mental retardation syndrome X-linked
AVPR2 arginine vasopressin receptor 2
AXDND1 axonemal dynein light chain domain containing 1
BCCIP BRCA2 and CDKN1A interacting protein
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL3 B-cell CLL/lymphoma 3
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BUD13 BUD13 homolog (S. cerevisiae)
C1QC complement component 1, q subcomponent, C chain
C2CD5 C2 calcium-dependent domain containing 5
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CANT1 calcium activated nucleotidase 1
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle)
CASZ1 castor zinc finger 1
CCDC12 coiled-coil domain containing 12
CCDC134 coiled-coil domain containing 134
CCDC57 coiled-coil domain containing 57
CCDC61 coiled-coil domain containing 61
CCS copper chaperone for superoxide dismutase
CD300LF CD300 molecule-like family member f
CD93 CD93 molecule
CDH18 cadherin 18, type 2
CDHR5 cadherin-related family member 5
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CDR2L cerebellar degeneration-related protein 2-like
CEL carboxyl ester lipase
CEP120 centrosomal protein 120kDa
CHD9 chromodomain helicase DNA binding protein 9
CHRM2 cholinergic receptor, muscarinic 2
CLASP1 cytoplasmic linker associated protein 1
CLEC4F C-type lectin domain family 4, member F
COG7 component of oligomeric golgi complex 7
COG8 component of oligomeric golgi complex 8
COL19A1 collagen, type XIX, alpha 1
COL22A1 collagen, type XXII, alpha 1
COL4A5 collagen, type IV, alpha 5
COPB1 coatomer protein complex, subunit beta 1
CSMD3 CUB and Sushi multiple domains 3
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTSL cathepsin L
CTTN cortactin
CUX1 cut-like homeobox 1
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
DBX1 developing brain homeobox 1
DCTN4 dynactin 4 (p62)
DCXR dicarbonyl/L-xylulose reductase
DDR2 discoidin domain receptor tyrosine kinase 2
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
DLG2 discs, large homolog 2 (Drosophila)
DOCK2 dedicator of cytokinesis 2
DOK2 docking protein 2, 56kDa
DOPEY2 dopey family member 2
DPCR1 diffuse panbronchiolitis critical region 1
DSC2 desmocollin 2
DSCAM Down syndrome cell adhesion molecule
DST dystonin
DUSP16 dual specificity phosphatase 16
EIF3M eukaryotic translation initiation factor 3, subunit M
EML5 echinoderm microtubule associated protein like 5
ENO1 enolase 1, (alpha)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC6L2 excision repair cross-complementation group 6-like 2
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2
EYS eyes shut homolog (Drosophila)
FAM71F2 family with sequence similarity 71, member F2
FAM76B family with sequence similarity 76, member B
FAM98C family with sequence similarity 98, member C
FAM9A family with sequence similarity 9, member A
FAT3 FAT atypical cadherin 3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP2 FK506 binding protein 2, 13kDa
FKBP6 FK506 binding protein 6, 36kDa
FLNC filamin C, gamma
FMO2 flavin containing monooxygenase 2 (non-functional)
FMO4 flavin containing monooxygenase 4
FNDC7 fibronectin type III domain containing 7
FRAS1 Fraser extracellular matrix complex subunit 1
FRG1 FSHD region gene 1
FRG1B FSHD region gene 1 family, member B
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5
GATAD2B GATA zinc finger domain containing 2B
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GBP7 guanylate binding protein 7
GIMAP6 GTPase, IMAP family member 6
GLI3 GLI family zinc finger 3
GOLGA8R golgin A8 family, member R
GOLIM4 golgi integral membrane protein 4
GPN1 GPN-loop GTPase 1
GPR35 G protein-coupled receptor 35
GPR78 G protein-coupled receptor 78
GRID2IP glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein
GRIK3 glutamate receptor, ionotropic, kainate 3
GRIK4 glutamate receptor, ionotropic, kainate 4
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRK6 G protein-coupled receptor kinase 6
GYPA glycophorin A (MNS blood group)
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HAND2 heart and neural crest derivatives expressed 2
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HEPACAM2 HEPACAM family member 2
HEXIM2 hexamethylene bis-acetamide inducible 2
HGD homogentisate 1,2-dioxygenase
HIST1H1T histone cluster 1, H1t
HIST1H2AK histone cluster 1, H2ak
HIST1H3E histone cluster 1, H3e
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HORMAD1 HORMA domain containing 1
HOXB4 homeobox B4
HRNR hornerin
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone
HYDIN HYDIN, axonemal central pair apparatus protein
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IGF2R insulin-like growth factor 2 receptor
IGSF9B immunoglobulin superfamily, member 9B
IL17RD interleukin 17 receptor D
IMMT inner membrane protein, mitochondrial
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INSIG1 insulin induced gene 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KAT6B K(lysine) acetyltransferase 6B
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNK16 potassium channel, two pore domain subfamily K, member 16
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5
KCNT2 potassium channel, sodium activated subfamily T, member 2
KDM2A lysine (K)-specific demethylase 2A
KDM2B lysine (K)-specific demethylase 2B
KIAA1217 KIAA1217
KIAA2013 KIAA2013
KIF17 kinesin family member 17
KIF21A kinesin family member 21A
KIF3C kinesin family member 3C
KLHDC8B kelch domain containing 8B
KLK12 kallikrein-related peptidase 12
KLK4 kallikrein-related peptidase 4
KMT2C lysine (K)-specific methyltransferase 2C
KRT20 keratin 20, type I
KRT33B keratin 33B, type I
KRTAP10-6 keratin associated protein 10-6
KRTAP13-2 keratin associated protein 13-2
KRTAP4-7 keratin associated protein 4-7
KRTAP4-9 keratin associated protein 4-9
LCE2D late cornified envelope 2D
LOC541473 FK506 binding protein 6, 36kDa pseudogene
LPL lipoprotein lipase
LRP2 low density lipoprotein receptor-related protein 2
LRRC49 leucine rich repeat containing 49
LRRC8A leucine rich repeat containing 8 family, member A
LRRN3 leucine rich repeat neuronal 3
LSP1 lymphocyte-specific protein 1
LSR lipolysis stimulated lipoprotein receptor
LZTS2 leucine zipper, putative tumor suppressor 2
MACF1 microtubule-actin crosslinking factor 1
MAEL maelstrom spermatogenic transposon silencer
MAL mal, T-cell differentiation protein
MAOB monoamine oxidase B
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP7D1 MAP7 domain containing 1
MAPT microtubule-associated protein tau
MAST4 microtubule associated serine/threonine kinase family member 4
MATN1 matrilin 1, cartilage matrix protein
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MDFI MyoD family inhibitor
MDN1 MDN1, midasin homolog (yeast)
MESDC1 mesoderm development candidate 1
METTL13 methyltransferase like 13
MGAM maltase-glucoamylase
MKI67 marker of proliferation Ki-67
MRPL45 mitochondrial ribosomal protein L45
MS4A14 membrane-spanning 4-domains, subfamily A, member 14
MSH6 mutS homolog 6
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC16 mucin 16, cell surface associated
MUC19 mucin 19, oligomeric
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal
MYO16 myosin XVI
MYO1B myosin IB
NAF1 nuclear assembly factor 1 ribonucleoprotein
NAV1 neuron navigator 1
NBEAL1 neurobeachin-like 1
NBPF10 neuroblastoma breakpoint family, member 10
NBR1 neighbor of BRCA1 gene 1
NCR1 natural cytotoxicity triggering receptor 1
NEFM neurofilament, medium polypeptide
NHP2 NHP2 ribonucleoprotein
NHSL1 NHS-like 1
NLGN1 neuroligin 1
NOG noggin
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPM3 nucleophosmin/nucleoplasmin 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP2 nuclear receptor interacting protein 2
NRP1 neuropilin 1
NRXN1 neurexin 1
NRXN3 neurexin 3
NSD1 nuclear receptor binding SET domain protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUCB2 nucleobindin 2
NUMA1 nuclear mitotic apparatus protein 1
NUP205 nucleoporin 205kDa
NUP214 nucleoporin 214kDa
NYNRIN NYN domain and retroviral integrase containing
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OR1C1 olfactory receptor, family 1, subfamily C, member 1
OR4K13 olfactory receptor, family 4, subfamily K, member 13
OR4X1 olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)
OR52M1 olfactory receptor, family 52, subfamily M, member 1
OR5AC2 olfactory receptor, family 5, subfamily AC, member 2
OR5AU1 olfactory receptor, family 5, subfamily AU, member 1
OR8H1 olfactory receptor, family 8, subfamily H, member 1
OXCT1 3-oxoacid CoA transferase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAPPA2 pappalysin 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PBRM1 polybromo 1
PCDHB11 protocadherin beta 11
PCDHB15 protocadherin beta 15
PCDHGA12 protocadherin gamma subfamily A, 12
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
PENK proenkephalin
PHC3 polyhomeotic homolog 3 (Drosophila)
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PIWIL2 piwi-like RNA-mediated gene silencing 2
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene)
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
PLLP plasmolipin
PLXNB2 plexin B2
POLQ polymerase (DNA directed), theta
PON3 paraoxonase 3
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1
PRCP prolylcarboxypeptidase (angiotensinase C)
PRG4 proteoglycan 4
PRODH proline dehydrogenase (oxidase) 1
PTCH2 patched 2
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRR protein tyrosine phosphatase, receptor type, R
PYCR2 pyrroline-5-carboxylate reductase family, member 2
QRFPR pyroglutamylated RFamide peptide receptor
RAD54L RAD54-like (S. cerevisiae)
RASGEF1B RasGEF domain family, member 1B
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM43 RNA binding motif protein 43
RCOR1 REST corepressor 1
RDH16 retinol dehydrogenase 16 (all-trans)
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RICTOR RPTOR independent companion of MTOR, complex 2
RIPPLY3 ripply transcriptional repressor 3
RNF152 ring finger protein 152
RNF213 ring finger protein 213
RNGTT RNA guanylyltransferase and 5'-phosphatase
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RP1 retinitis pigmentosa 1 (autosomal dominant)
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1
RYR1 ryanodine receptor 1 (skeletal)
SART1 squamous cell carcinoma antigen recognized by T cells
SCAF11 SR-related CTD-associated factor 11
SCARF1 scavenger receptor class F, member 1
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN9A sodium channel, voltage gated, type IX alpha subunit
SEC24C SEC24 family member C
SEPT3 septin 3
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SETBP1 SET binding protein 1
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SHROOM2 shroom family member 2
SIPA1L2 signal-induced proliferation-associated 1 like 2
SKAP1 src kinase associated phosphoprotein 1
SLC17A1 solute carrier family 17 (organic anion transporter), member 1
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6
SLC22A9 solute carrier family 22 (organic anion transporter), member 9
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC39A11 solute carrier family 39, member 11
SLC51B solute carrier family 51, beta subunit
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SLIT3 slit homolog 3 (Drosophila)
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SORCS1 sortilin-related VPS10 domain containing receptor 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAG11A sperm associated antigen 11A
SPATA5L1 spermatogenesis associated 5-like 1
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SPON1 spondin 1, extracellular matrix protein
SPTB spectrin, beta, erythrocytic
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1
STAB2 stabilin 2
STK17A serine/threonine kinase 17a
STK40 serine/threonine kinase 40
STOML3 stomatin (EPB72)-like 3
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SV2A synaptic vesicle glycoprotein 2A
SYT2 synaptotagmin II
TACC2 transforming, acidic coiled-coil containing protein 2
TAL1 T-cell acute lymphocytic leukemia 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TBPL2 TATA box binding protein like 2
TEX15 testis expressed 15
TGFBR3 transforming growth factor, beta receptor III
TGM1 transglutaminase 1
THRB thyroid hormone receptor, beta
THSD7B thrombospondin, type I, domain containing 7B
TMCO3 transmembrane and coiled-coil domains 3
TMEM132D transmembrane protein 132D
TMEM168 transmembrane protein 168
TMPRSS15 transmembrane protease, serine 15
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TOX thymocyte selection-associated high mobility group box
TP53 tumor protein p53
TPTE transmembrane phosphatase with tensin homology
TRIM15 tripartite motif containing 15
TUBGCP3 tubulin, gamma complex associated protein 3
TULP2 tubby like protein 2
TWISTNB TWIST neighbor
UBA2 ubiquitin-like modifier activating enzyme 2
UBA6 ubiquitin-like modifier activating enzyme 6
UHRF1BP1 UHRF1 binding protein 1
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
USP31 ubiquitin specific peptidase 31
USP45 ubiquitin specific peptidase 45
USP6NL USP6 N-terminal like
UTRN utrophin
VWA2 von Willebrand factor A domain containing 2
VWDE von Willebrand factor D and EGF domains
WASL Wiskott-Aldrich syndrome-like
WBSCR17 Williams-Beuren syndrome chromosome region 17
WDR35 WD repeat domain 35
WDR36 WD repeat domain 36
YEATS2 YEATS domain containing 2
YIPF1 Yip1 domain family, member 1
YME1L1 YME1-like 1 ATPase
ZBTB49 zinc finger and BTB domain containing 49
ZFHX4 zinc finger homeobox 4
ZFPM2 zinc finger protein, FOG family member 2
ZMYM2 zinc finger, MYM-type 2
ZNF107 zinc finger protein 107
ZNF215 zinc finger protein 215
ZNF345 zinc finger protein 345
ZNF385C zinc finger protein 385C
ZNF507 zinc finger protein 507
ZNF534 zinc finger protein 534
ZNF607 zinc finger protein 607
ZNF646 zinc finger protein 646
ZNF69 zinc finger protein 69
ZRANB3 zinc finger, RAN-binding domain containing 3