NCI-H810 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description disease: large cell; neuroendocrine; carcinoma; non-small cell lung cancer (Cell Line Ontology, CLO_0008117)
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221 genes mutated in the NCI-H810 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ACAD11 acyl-CoA dehydrogenase family, member 11
ACIN1 apoptotic chromatin condensation inducer 1
ADCK1 aarF domain containing kinase 1
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AGRN agrin
ALDOC aldolase C, fructose-bisphosphate
ALG10 ALG10, alpha-1,2-glucosyltransferase
AMBP alpha-1-microglobulin/bikunin precursor
ANKRD50 ankyrin repeat domain 50
ANO5 anoctamin 5
ARHGAP23 Rho GTPase activating protein 23
ARHGAP4 Rho GTPase activating protein 4
ARID1A AT rich interactive domain 1A (SWI-like)
ASB7 ankyrin repeat and SOCS box containing 7
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATM ATM serine/threonine kinase
ATN1 atrophin 1
ATP9A ATPase, class II, type 9A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BMPR1B bone morphogenetic protein receptor, type IB
BOP1 block of proliferation 1
BRSK2 BR serine/threonine kinase 2
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C17ORF80 chromosome 17 open reading frame 80
C3ORF52 chromosome 3 open reading frame 52
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha
CASZ1 castor zinc finger 1
CCDC67 coiled-coil domain containing 67
CD2AP CD2-associated protein
CD59 CD59 molecule, complement regulatory protein
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CENPE centromere protein E, 312kDa
CENPJ centromere protein J
CEP164 centrosomal protein 164kDa
CEP290 centrosomal protein 290kDa
CHD4 chromodomain helicase DNA binding protein 4
CHID1 chitinase domain containing 1
CMIP c-Maf inducing protein
COASY CoA synthase
CPPED1 calcineurin-like phosphoesterase domain containing 1
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CRAMP1L Crm, cramped-like (Drosophila)
CSMD3 CUB and Sushi multiple domains 3
CTNNA2 catenin (cadherin-associated protein), alpha 2
CWF19L2 CWF19-like 2, cell cycle control (S. pombe)
DCHS2 dachsous cadherin-related 2
DDIAS DNA damage-induced apoptosis suppressor
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DEPDC1B DEP domain containing 1B
DLX5 distal-less homeobox 5
DNPEP aspartyl aminopeptidase
DOLK dolichol kinase
DPY19L3 dpy-19-like 3 (C. elegans)
DSP desmoplakin
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
ECE1 endothelin converting enzyme 1
EMILIN2 elastin microfibril interfacer 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERI1 exoribonuclease 1
ERLIN2 ER lipid raft associated 2
ESPN espin
FAM110B family with sequence similarity 110, member B
FAM171A2 family with sequence similarity 171, member A2
FAM179B family with sequence similarity 179, member B
FANCB Fanconi anemia, complementation group B
FGD6 FYVE, RhoGEF and PH domain containing 6
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GLRB glycine receptor, beta
GOLIM4 golgi integral membrane protein 4
GSS glutathione synthetase
GTDC1 glycosyltransferase-like domain containing 1
GTF2A2 general transcription factor IIA, 2, 12kDa
GTPBP2 GTP binding protein 2
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IGF1R insulin-like growth factor 1 receptor
IGSF3 immunoglobulin superfamily, member 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INSM1 insulinoma-associated 1
INTU inturned planar cell polarity protein
IQSEC1 IQ motif and Sec7 domain 1
KALRN kalirin, RhoGEF kinase
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8
KCNK13 potassium channel, two pore domain subfamily K, member 13
KHSRP KH-type splicing regulatory protein
KIAA0586 KIAA0586
KIF3C kinesin family member 3C
LAMA5 laminin, alpha 5
LMNB1 lamin B1
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LUZP1 leucine zipper protein 1
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MAP1B microtubule-associated protein 1B
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MCF2L MCF.2 cell line derived transforming sequence-like
MCU mitochondrial calcium uniporter
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFF mitochondrial fission factor
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MRPL21 mitochondrial ribosomal protein L21
MRPL44 mitochondrial ribosomal protein L44
MTFR2 mitochondrial fission regulator 2
MUC4 mucin 4, cell surface associated
MVK mevalonate kinase
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
NARF nuclear prelamin A recognition factor
NBAS neuroblastoma amplified sequence
NBEA neurobeachin
NCOA2 nuclear receptor coactivator 2
NFASC neurofascin
NOP2 NOP2 nucleolar protein
NPM2 nucleophosmin/nucleoplasmin 2
NRD1 nardilysin (N-arginine dibasic convertase)
NRXN1 neurexin 1
NUP188 nucleoporin 188kDa
NWD2 NACHT and WD repeat domain containing 2
OCLN occludin
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PCDHA6 protocadherin alpha 6
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK9 proprotein convertase subtilisin/kexin type 9
PDLIM5 PDZ and LIM domain 5
PGM1 phosphoglucomutase 1
PHIP pleckstrin homology domain interacting protein
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
PLXNA1 plexin A1
PMFBP1 polyamine modulated factor 1 binding protein 1
PNMA2 paraneoplastic Ma antigen 2
PNPLA8 patatin-like phospholipase domain containing 8
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPIG peptidylprolyl isomerase G (cyclophilin G)
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PRADC1 protease-associated domain containing 1
PRR14 proline rich 14
PRRC2B proline-rich coiled-coil 2B
PRTFDC1 phosphoribosyl transferase domain containing 1
PRUNE2 prune homolog 2 (Drosophila)
PTGES2 prostaglandin E synthase 2
PTPN3 protein tyrosine phosphatase, non-receptor type 3
PUS7 pseudouridylate synthase 7 (putative)
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB19 RAB19, member RAS oncogene family
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RELN reelin
RIMBP2 RIMS binding protein 2
RIMS2 regulating synaptic membrane exocytosis 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SACS sacsin molecular chaperone
SBK1 SH3 domain binding kinase 1
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SDHAF4 succinate dehydrogenase complex assembly factor 4
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SEPT8 septin 8
SETBP1 SET binding protein 1
SETD1A SET domain containing 1A
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SOGA1 suppressor of glucose, autophagy associated 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRP19 signal recognition particle 19kDa
STAMBP STAM binding protein
STARD5 StAR-related lipid transfer (START) domain containing 5
STARD9 StAR-related lipid transfer (START) domain containing 9
STK11 serine/threonine kinase 11
SYCE1L synaptonemal complex central element protein 1-like
SYNGAP1 synaptic Ras GTPase activating protein 1
TACC2 transforming, acidic coiled-coil containing protein 2
TAGLN transgelin
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBL2 transducin (beta)-like 2
TEN1 TEN1 CST complex subunit
TEX14 testis expressed 14
THSD4 thrombospondin, type I, domain containing 4
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMSB15A thymosin beta 15a
TNK2 tyrosine kinase, non-receptor, 2
TNRC6A trinucleotide repeat containing 6A
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated
TRADD TNFRSF1A-associated via death domain
TRIM68 tripartite motif containing 68
TSSK3 testis-specific serine kinase 3
TTC3 tetratricopeptide repeat domain 3
TTC7B tetratricopeptide repeat domain 7B
TTI1 TELO2 interacting protein 1
TTN titin
TXNDC11 thioredoxin domain containing 11
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UNC5A unc-5 homolog A (C. elegans)
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VEZT vezatin, adherens junctions transmembrane protein
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDFY3 WD repeat and FYVE domain containing 3
WDR89 WD repeat domain 89
WEE1 WEE1 G2 checkpoint kinase
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WNK2 WNK lysine deficient protein kinase 2
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XPO6 exportin 6
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZCCHC11 zinc finger, CCHC domain containing 11
ZDBF2 zinc finger, DBF-type containing 2
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF101 zinc finger protein 101
ZNF18 zinc finger protein 18
ZNF710 zinc finger protein 710
ZNF841 zinc finger protein 841
ZSCAN12 zinc finger and SCAN domain containing 12