NCI-H69 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Human Caucasian lung small cell carcinoma cell line. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003022)
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419 genes mutated in the NCI-H69 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACACA acetyl-CoA carboxylase alpha
ACLY ATP citrate lyase
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGB androglobin
ADGRA3 adhesion G protein-coupled receptor A3
ADRBK2 adrenergic, beta, receptor kinase 2
AHNAK2 AHNAK nucleoprotein 2
ALPK1 alpha-kinase 1
ALS2CR11 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11
AMPD3 adenosine monophosphate deaminase 3
ANKDD1A ankyrin repeat and death domain containing 1A
ANKRD20A4 ankyrin repeat domain 20 family, member A4
ANKRD24 ankyrin repeat domain 24
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ANKRD28 ankyrin repeat domain 28
ANO5 anoctamin 5
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APC adenomatous polyposis coli
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ATF5 activating transcription factor 5
ATG16L2 autophagy related 16-like 2 (S. cerevisiae)
ATM ATM serine/threonine kinase
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BATF2 basic leucine zipper transcription factor, ATF-like 2
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BMP6 bone morphogenetic protein 6
BOD1L1 biorientation of chromosomes in cell division 1-like 1
BST2 bone marrow stromal cell antigen 2
BTBD7 BTB (POZ) domain containing 7
BTD biotinidase
C1QTNF6 C1q and tumor necrosis factor related protein 6
C6 complement component 6
CABIN1 calcineurin binding protein 1
CADM1 cell adhesion molecule 1
CAPN12 calpain 12
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBWD3 COBW domain containing 3
CCDC77 coiled-coil domain containing 77
CCDC89 coiled-coil domain containing 89
CCNB2 cyclin B2
CD47 CD47 molecule
CD83 CD83 molecule
CDK11B cyclin-dependent kinase 11B
CDKL5 cyclin-dependent kinase-like 5
CEP112 centrosomal protein 112kDa
CHD9 chromodomain helicase DNA binding protein 9
CHL1 cell adhesion molecule L1-like
CHRD chordin
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CMTM5 CKLF-like MARVEL transmembrane domain containing 5
CMYA5 cardiomyopathy associated 5
CNBD1 cyclic nucleotide binding domain containing 1
CNGB3 cyclic nucleotide gated channel beta 3
CNTNAP3B contactin associated protein-like 3B
COL22A1 collagen, type XXII, alpha 1
COL9A1 collagen, type IX, alpha 1
COLEC12 collectin sub-family member 12
CPEB4 cytoplasmic polyadenylation element binding protein 4
CPNE7 copine VII
CREB3L4 cAMP responsive element binding protein 3-like 4
CRLS1 cardiolipin synthase 1
CTGF connective tissue growth factor
CUBN cubilin (intrinsic factor-cobalamin receptor)
CYB561 cytochrome b561
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22
DCAKD dephospho-CoA kinase domain containing
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila)
DKKL1 dickkopf-like 1
DLC1 DLC1 Rho GTPase activating protein
DNAH1 dynein, axonemal, heavy chain 1
DNAH14 dynein, axonemal, heavy chain 14
DPP9 dipeptidyl-peptidase 9
DPYSL2 dihydropyrimidinase-like 2
DSCAML1 Down syndrome cell adhesion molecule like 1
DSP desmoplakin
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EBF1 early B-cell factor 1
EHD1 EH-domain containing 1
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1
ERGIC2 ERGIC and golgi 2
ERI2 ERI1 exoribonuclease family member 2
ERP44 endoplasmic reticulum protein 44
F2 coagulation factor II (thrombin)
FAM187A family with sequence similarity 187, member A
FCGBP Fc fragment of IgG binding protein
FCRL5 Fc receptor-like 5
FER1L6 fer-1-like family member 6
FLG filaggrin
FLG2 filaggrin family member 2
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLNC filamin C, gamma
FREM3 FRAS1 related extracellular matrix 3
FRG1B FSHD region gene 1 family, member B
FRMD4A FERM domain containing 4A
FSCB fibrous sheath CABYR binding protein
FXYD5 FXYD domain containing ion transport regulator 5
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18
GALR2 galanin receptor 2
GATAD1 GATA zinc finger domain containing 1
GCDH glutaryl-CoA dehydrogenase
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GGN gametogenetin
GH1 growth hormone 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GPR137 G protein-coupled receptor 137
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPR4 G protein-coupled receptor 4
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRK6 G protein-coupled receptor kinase 6
GRM1 glutamate receptor, metabotropic 1
GRXCR1 glutaredoxin, cysteine rich 1
GTF2H5 general transcription factor IIH, polypeptide 5
GUK1 guanylate kinase 1
HAVCR2 hepatitis A virus cellular receptor 2
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1
HEG1 heart development protein with EGF-like domains 1
HIST1H2BA histone cluster 1, H2ba
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMCN1 hemicentin 1
HMOX1 heme oxygenase 1
HPD 4-hydroxyphenylpyruvate dioxygenase
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic
HYDIN HYDIN, axonemal central pair apparatus protein
ICE1 interactor of little elongation complex ELL subunit 1
IFNA1 interferon, alpha 1
IFNL2 interferon, lambda 2
IFT122 intraflagellar transport 122
INF2 inverted formin, FH2 and WH2 domain containing
IRGQ immunity-related GTPase family, Q
ITFG3 integrin alpha FG-GAP repeat containing 3
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1
ITPKB inositol-trisphosphate 3-kinase B
KALRN kalirin, RhoGEF kinase
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNK6 potassium channel, two pore domain subfamily K, member 6
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2
KIAA1161 KIAA1161
KIAA1671 KIAA1671
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KLK5 kallikrein-related peptidase 5
KMT2A lysine (K)-specific methyltransferase 2A
KMT2C lysine (K)-specific methyltransferase 2C
KMT2E lysine (K)-specific methyltransferase 2E
KRT8P11 keratin 8 pseudogene 11
KRTAP10-12 keratin associated protein 10-12
KRTAP10-3 keratin associated protein 10-3
KRTAP10-4 keratin associated protein 10-4
KRTAP26-1 keratin associated protein 26-1
LAMA1 laminin, alpha 1
LCA5 Leber congenital amaurosis 5
LEMD2 LEM domain containing 2
LGALS13 lectin, galactoside-binding, soluble, 13
LOC81691 exonuclease NEF-sp
LOXHD1 lipoxygenase homology domains 1
LRRC25 leucine rich repeat containing 25
LRRN2 leucine rich repeat neuronal 2
MAP1B microtubule-associated protein 1B
MAP2K4 mitogen-activated protein kinase kinase 4
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAS1L MAS1 proto-oncogene like, G protein-coupled receptor
MAST1 microtubule associated serine/threonine kinase 1
MECP2 methyl CpG binding protein 2
MED29 mediator complex subunit 29
MED7 mediator complex subunit 7
MKL2 MKL/myocardin-like 2
MPHOSPH8 M-phase phosphoprotein 8
MROH2B maestro heat-like repeat family member 2B
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MTMR4 myotubularin related protein 4
MUC12 mucin 12, cell surface associated
MUC16 mucin 16, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC4 mucin 4, cell surface associated
MVB12A multivesicular body subunit 12A
MYBPC3 myosin binding protein C, cardiac
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
MYO16 myosin XVI
MYO18B myosin XVIIIB
MYO5A myosin VA (heavy chain 12, myoxin)
MYT1L myelin transcription factor 1-like
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma
NBPF10 neuroblastoma breakpoint family, member 10
NCAM2 neural cell adhesion molecule 2
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
NCKAP5L NCK-associated protein 5-like
NCOA5 nuclear receptor coactivator 5
NCR2 natural cytotoxicity triggering receptor 2
NIPBL Nipped-B homolog (Drosophila)
NLRC3 NLR family, CARD domain containing 3
NLRC4 NLR family, CARD domain containing 4
NLRP13 NLR family, pyrin domain containing 13
NMUR2 neuromedin U receptor 2
NOTCH4 notch 4
NRXN3 neurexin 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUAK1 NUAK family, SNF1-like kinase, 1
NWD1 NACHT and WD repeat domain containing 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OR10G9 olfactory receptor, family 10, subfamily G, member 9
OR2AK2 olfactory receptor, family 2, subfamily AK, member 2
OR2M2 olfactory receptor, family 2, subfamily M, member 2
OR2T12 olfactory receptor, family 2, subfamily T, member 12
OR4C46 olfactory receptor, family 4, subfamily C, member 46
OR4K15 olfactory receptor, family 4, subfamily K, member 15
OR4N4 olfactory receptor, family 4, subfamily N, member 4
OR51B5 olfactory receptor, family 51, subfamily B, member 5
OR51I2 olfactory receptor, family 51, subfamily I, member 2
OR52R1 olfactory receptor, family 52, subfamily R, member 1 (gene/pseudogene)
OR5AP2 olfactory receptor, family 5, subfamily AP, member 2
OR5T2 olfactory receptor, family 5, subfamily T, member 2
OR6M1 olfactory receptor, family 6, subfamily M, member 1
OSMR oncostatin M receptor
PAN3 PAN3 poly(A) specific ribonuclease subunit
PANK3 pantothenate kinase 3
PCDH11Y protocadherin 11 Y-linked
PCDHA1 protocadherin alpha 1
PCDHB11 protocadherin beta 11
PCDHB12 protocadherin beta 12
PCDHB16 protocadherin beta 16
PCDHB8 protocadherin beta 8
PCDHGA7 protocadherin gamma subfamily A, 7
PCDHGB2 protocadherin gamma subfamily B, 2
PDCD11 programmed cell death 11
PDCD7 programmed cell death 7
PEX6 peroxisomal biogenesis factor 6
PHC3 polyhomeotic homolog 3 (Drosophila)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB4 phospholipase C, beta 4
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLXNA4 plexin A4
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PNLIP pancreatic lipase
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
PON1 paraoxonase 1
POT1 protection of telomeres 1
POTEG POTE ankyrin domain family, member G
PPAN peter pan homolog (Drosophila)
PPAN-P2RY11 PPAN-P2RY11 readthrough
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R42 protein phosphatase 1, regulatory subunit 42
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRCP prolylcarboxypeptidase (angiotensinase C)
PRKCB protein kinase C, beta
PRR14 proline rich 14
PRSS54 protease, serine, 54
PRSS57 protease, serine, 57
PRTFDC1 phosphoribosyl transferase domain containing 1
PSG6 pregnancy specific beta-1-glycoprotein 6
PSG8 pregnancy specific beta-1-glycoprotein 8
PTGES2 prostaglandin E synthase 2
PTGR2 prostaglandin reductase 2
PTPN3 protein tyrosine phosphatase, non-receptor type 3
PWWP2B PWWP domain containing 2B
PYCR1 pyrroline-5-carboxylate reductase 1
PYHIN1 pyrin and HIN domain family, member 1
QRICH2 glutamine rich 2
RADIL Ras association and DIL domains
RB1 retinoblastoma 1
RBBP6 retinoblastoma binding protein 6
RBM15 RNA binding motif protein 15
RBSN rabenosyn, RAB effector
RCL1 RNA terminal phosphate cyclase-like 1
RECQL4 RecQ protein-like 4
RERE arginine-glutamic acid dipeptide (RE) repeats
RFC1 replication factor C (activator 1) 1, 145kDa
RFTN2 raftlin family member 2
RGAG4 retrotransposon gag domain containing 4
RHCG Rh family, C glycoprotein
RIC8B RIC8 guanine nucleotide exchange factor B
RIF1 replication timing regulatory factor 1
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
ROR2 receptor tyrosine kinase-like orphan receptor 2
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RP1L1 retinitis pigmentosa 1-like 1
RPL3 ribosomal protein L3
RSF1 remodeling and spacing factor 1
RTBDN retbindin
RTTN rotatin
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
RYR3 ryanodine receptor 3
SCFD2 sec1 family domain containing 2
SCIN scinderin
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN4A sodium channel, voltage gated, type IV alpha subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SCRIB scribbled planar cell polarity protein
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SFT2D2 SFT2 domain containing 2
SFTPB surfactant protein B
SH3RF1 SH3 domain containing ring finger 1
SHARPIN SHANK-associated RH domain interactor
SIGLEC12 sialic acid binding Ig-like lectin 12 (gene/pseudogene)
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC29A4 solute carrier family 29 (equilibrative nucleoside transporter), member 4
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLFN13 schlafen family member 13
SLIT3 slit homolog 3 (Drosophila)
SMAP1 small ArfGAP 1
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SP3 Sp3 transcription factor
SPATA5 spermatogenesis associated 5
SPN sialophorin
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SRGN serglycin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STON1 stonin 1
STON1-GTF2A1L STON1-GTF2A1L readthrough
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SYNE1 spectrin repeat containing, nuclear envelope 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAS2R30 taste receptor, type 2, member 30
TEAD4 TEA domain family member 4
TEKT4 tektin 4
TENM2 teneurin transmembrane protein 2
TGM6 transglutaminase 6
THSD1 thrombospondin, type I, domain containing 1
THYN1 thymocyte nuclear protein 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TLR7 toll-like receptor 7
TMEM147 transmembrane protein 147
TMEM200B transmembrane protein 200B
TMEM92 transmembrane protein 92
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TOP3B topoisomerase (DNA) III beta
TP53 tumor protein p53
TPM2 tropomyosin 2 (beta)
TPR translocated promoter region, nuclear basket protein
TPTE transmembrane phosphatase with tensin homology
TREH trehalase (brush-border membrane glycoprotein)
TRIM50 tripartite motif containing 50
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TRRAP transformation/transcription domain-associated protein
TTLL4 tubulin tyrosine ligase-like family member 4
TTLL8 tubulin tyrosine ligase-like family member 8
TTN titin
TULP4 tubby like protein 4
USP29 ubiquitin specific peptidase 29
USP32 ubiquitin specific peptidase 32
USP51 ubiquitin specific peptidase 51
VIM vimentin
VIP vasoactive intestinal peptide
VRK1 vaccinia related kinase 1
VRTN vertebrae development associated
WDFY3 WD repeat and FYVE domain containing 3
WDR62 WD repeat domain 62
WISP2 WNT1 inducible signaling pathway protein 2
WNT3A wingless-type MMTV integration site family, member 3A
WRN Werner syndrome, RecQ helicase-like
WWC2 WW and C2 domain containing 2
XKR4 XK, Kell blood group complex subunit-related family, member 4
XYLT2 xylosyltransferase II
YIPF3 Yip1 domain family, member 3
ZBTB40 zinc finger and BTB domain containing 40
ZC3H13 zinc finger CCCH-type containing 13
ZCCHC16 zinc finger, CCHC domain containing 16
ZEB1 zinc finger E-box binding homeobox 1
ZEB2 zinc finger E-box binding homeobox 2
ZFHX4 zinc finger homeobox 4
ZNF236 zinc finger protein 236
ZNF268 zinc finger protein 268
ZNF318 zinc finger protein 318
ZNF358 zinc finger protein 358
ZNF397 zinc finger protein 397
ZNF417 zinc finger protein 417
ZNF479 zinc finger protein 479
ZNF510 zinc finger protein 510
ZNF541 zinc finger protein 541
ZNF551 zinc finger protein 551
ZNF574 zinc finger protein 574
ZNF646 zinc finger protein 646
ZNF655 zinc finger protein 655
ZNF658 zinc finger protein 658
ZNF677 zinc finger protein 677
ZNF681 zinc finger protein 681
ZNF716 zinc finger protein 716
ZNF776 zinc finger protein 776
ZNF844 zinc finger protein 844
ZNF91 zinc finger protein 91
ZNF99 zinc finger protein 99
ZSWIM1 zinc finger, SWIM-type containing 1