NCI-H660 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Homo sapiens (human) lung; small cell lung cancer cell line, extrapulmonary origin; established from a 63 years adult caucasian male. Morphology: epithelial; cell type: neuroendocrine; Tumor stage E; derived from metastatic site: lymph node. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001970)
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Genes

392 genes mutated in the NCI-H660 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACSL4 acyl-CoA synthetase long-chain family member 4
ADAM7 ADAM metallopeptidase domain 7
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2
ADARB1 adenosine deaminase, RNA-specific, B1
ADCY1 adenylate cyclase 1 (brain)
ADGRD1 adhesion G protein-coupled receptor D1
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL2 adhesion G protein-coupled receptor L2
AFAP1 actin filament associated protein 1
AGGF1 angiogenic factor with G patch and FHA domains 1
AHNAK2 AHNAK nucleoprotein 2
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2
AK8 adenylate kinase 8
ALOX15B arachidonate 15-lipoxygenase, type B
ALS2CR11 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11
AMER3 APC membrane recruitment protein 3
AMOTL2 angiomotin like 2
ANKLE1 ankyrin repeat and LEM domain containing 1
ANKRD12 ankyrin repeat domain 12
ANKRD35 ankyrin repeat domain 35
ANXA9 annexin A9
AOAH acyloxyacyl hydrolase (neutrophil)
AQP5 aquaporin 5
AQR aquarius intron-binding spliceosomal factor
ARHGAP26 Rho GTPase activating protein 26
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARID4A AT rich interactive domain 4A (RBP1-like)
ART4 ADP-ribosyltransferase 4 (Dombrock blood group)
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPH aspartate beta-hydroxylase
ATF7IP2 activating transcription factor 7 interacting protein 2
ATG14 autophagy related 14
ATP10B ATPase, class V, type 10B
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide
ATP6AP1L ATPase, H+ transporting, lysosomal accessory protein 1-like
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3
B4GALNT4 beta-1,4-N-acetyl-galactosaminyl transferase 4
BMP4 bone morphogenetic protein 4
BTBD7 BTB (POZ) domain containing 7
CABLES2 Cdk5 and Abl enzyme substrate 2
CAMKMT calmodulin-lysine N-methyltransferase
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CAPG capping protein (actin filament), gelsolin-like
CAPN1 calpain 1, (mu/I) large subunit
CAPN8 calpain 8
CAPS2 calcyphosine 2
CARD6 caspase recruitment domain family, member 6
CATSPER2 cation channel, sperm associated 2
CCDC159 coiled-coil domain containing 159
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CDK18 cyclin-dependent kinase 18
CEL carboxyl ester lipase
CEP192 centrosomal protein 192kDa
CFAP46 cilia and flagella associated protein 46
CHD9 chromodomain helicase DNA binding protein 9
CHN2 chimerin 2
CLCA4 chloride channel accessory 4
CLEC7A C-type lectin domain family 7, member A
CNGA1 cyclic nucleotide gated channel alpha 1
COL1A2 collagen, type I, alpha 2
COL9A1 collagen, type IX, alpha 1
COL9A3 collagen, type IX, alpha 3
COPG1 coatomer protein complex, subunit gamma 1
CPNE6 copine VI (neuronal)
CPXM2 carboxypeptidase X (M14 family), member 2
CR2 complement component (3d/Epstein Barr virus) receptor 2
CSAD cysteine sulfinic acid decarboxylase
CSMD3 CUB and Sushi multiple domains 3
CT47B1 cancer/testis antigen family 47, member B1
CTTNBP2 cortactin binding protein 2
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1
DAZAP1 DAZ associated protein 1
DCHS1 dachsous cadherin-related 1
DDX12P DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
DHRS4L2 dehydrogenase/reductase (SDR family) member 4 like 2
DIAPH1 diaphanous-related formin 1
DLGAP2 discs, large (Drosophila) homolog-associated protein 2
DNAH10 dynein, axonemal, heavy chain 10
DNAH12 dynein, axonemal, heavy chain 12
DNAH6 dynein, axonemal, heavy chain 6
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11
DOCK10 dedicator of cytokinesis 10
DOCK11 dedicator of cytokinesis 11
DPH5 diphthamide biosynthesis 5
DROSHA drosha, ribonuclease type III
DTX2 deltex 2, E3 ubiquitin ligase
DVL1 dishevelled segment polarity protein 1
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DZIP3 DAZ interacting zinc finger protein 3
EBF1 early B-cell factor 1
EBF3 early B-cell factor 3
EFCAB5 EF-hand calcium binding domain 5
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
EML1 echinoderm microtubule associated protein like 1
EML6 echinoderm microtubule associated protein like 6
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EPHA2 EPH receptor A2
ERI1 exoribonuclease 1
ESYT1 extended synaptotagmin-like protein 1
F2RL3 coagulation factor II (thrombin) receptor-like 3
F5 coagulation factor V (proaccelerin, labile factor)
F9 coagulation factor IX
FAM135B family with sequence similarity 135, member B
FAM170A family with sequence similarity 170, member A
FAM196A family with sequence similarity 196, member A
FAM196B family with sequence similarity 196, member B
FAM21C family with sequence similarity 21, member C
FAM65B family with sequence similarity 65, member B
FBXO10 F-box protein 10
FBXO21 F-box protein 21
FBXW2 F-box and WD repeat domain containing 2
FCRL1 Fc receptor-like 1
FEZF2 FEZ family zinc finger 2
FNIP1 folliculin interacting protein 1
FOXL1 forkhead box L1
FPR3 formyl peptide receptor 3
FREM3 FRAS1 related extracellular matrix 3
FRG1 FSHD region gene 1
FRG2B FSHD region gene 2 family, member B
FRG2C FSHD region gene 2 family, member C
FRMD4A FERM domain containing 4A
FRMPD4 FERM and PDZ domain containing 4
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9
GATA1 GATA binding protein 1 (globin transcription factor 1)
GBP2 guanylate binding protein 2, interferon-inducible
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GDF2 growth differentiation factor 2
GLB1 galactosidase, beta 1
GLI1 GLI family zinc finger 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GRIK4 glutamate receptor, ionotropic, kainate 4
GRIP1 glutamate receptor interacting protein 1
GTPBP3 GTP binding protein 3 (mitochondrial)
GYPA glycophorin A (MNS blood group)
GYS1 glycogen synthase 1 (muscle)
HAL histidine ammonia-lyase
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HGFAC HGF activator
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLA-A major histocompatibility complex, class I, A
HLA-C major histocompatibility complex, class I, C
HNF1A HNF1 homeobox A
HNMT histamine N-methyltransferase
HOXB3 homeobox B3
HOXC9 homeobox C9
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HYDIN HYDIN, axonemal central pair apparatus protein
IL22RA2 interleukin 22 receptor, alpha 2
INMT indolethylamine N-methyltransferase
ITGAD integrin, alpha D
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JARID2 jumonji, AT rich interactive domain 2
KAT6B K(lysine) acetyltransferase 6B
KCNK9 potassium channel, two pore domain subfamily K, member 9
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5
KCTD3 potassium channel tetramerization domain containing 3
KIAA1671 KIAA1671
KIF13A kinesin family member 13A
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KLHL31 kelch-like family member 31
KLKB1 kallikrein B, plasma (Fletcher factor) 1
KRT4 keratin 4, type II
KRTAP20-2 keratin associated protein 20-2
KSR1 kinase suppressor of ras 1
LAMA3 laminin, alpha 3
LAMB1 laminin, beta 1
LCE1F late cornified envelope 1F
LCN8 lipocalin 8
LIG4 ligase IV, DNA, ATP-dependent
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LPA lipoprotein, Lp(a)
LRP1 low density lipoprotein receptor-related protein 1
LRRC61 leucine rich repeat containing 61
LSG1 large 60S subunit nuclear export GTPase 1
LYPLA1 lysophospholipase I
MACF1 microtubule-actin crosslinking factor 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MATN4 matrilin 4
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MFSD11 major facilitator superfamily domain containing 11
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLH1 mutL homolog 1
MMP13 matrix metallopeptidase 13
MOAP1 modulator of apoptosis 1
MRPS5 mitochondrial ribosomal protein S5
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
MTMR7 myotubularin related protein 7
MUC16 mucin 16, cell surface associated
MUC4 mucin 4, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MUC6 mucin 6, oligomeric mucus/gel-forming
MYBBP1A MYB binding protein (P160) 1a
MYCT1 myc target 1
MYO10 myosin X
MYO3B myosin IIIB
MYO5B myosin VB
MYO7B myosin VIIB
MYO9B myosin IXB
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
MYOM1 myomesin 1
NAT10 N-acetyltransferase 10 (GCN5-related)
NAV3 neuron navigator 3
NBPF14 neuroblastoma breakpoint family, member 14
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NID2 nidogen 2 (osteonidogen)
NINL ninein-like
NKD2 naked cuticle homolog 2 (Drosophila)
NLRC4 NLR family, CARD domain containing 4
NLRP1 NLR family, pyrin domain containing 1
NLRP13 NLR family, pyrin domain containing 13
NOL11 nucleolar protein 11
NOSTRIN nitric oxide synthase trafficking
NOTCH3 notch 3
NPAS3 neuronal PAS domain protein 3
NQO2 NAD(P)H dehydrogenase, quinone 2
NRROS negative regulator of reactive oxygen species
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NT5DC3 5'-nucleotidase domain containing 3
NTN4 netrin 4
NUP107 nucleoporin 107kDa
NWD1 NACHT and WD repeat domain containing 1
NXNL1 nucleoredoxin-like 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OBSL1 obscurin-like 1
OGFR opioid growth factor receptor
OR10H5 olfactory receptor, family 10, subfamily H, member 5
OR2T33 olfactory receptor, family 2, subfamily T, member 33
OR3A2 olfactory receptor, family 3, subfamily A, member 2
OR51I1 olfactory receptor, family 51, subfamily I, member 1
OR52B6 olfactory receptor, family 52, subfamily B, member 6
OR7A17 olfactory receptor, family 7, subfamily A, member 17
OR8B3 olfactory receptor, family 8, subfamily B, member 3
OTOA otoancorin
OTUD7B OTU deubiquitinase 7B
PAX1 paired box 1
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCLO piccolo presynaptic cytomatrix protein
PCNXL3 pecanex-like 3 (Drosophila)
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDE4A phosphodiesterase 4A, cAMP-specific
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PDYN prodynorphin
PDZD3 PDZ domain containing 3
PELI1 pellino E3 ubiquitin protein ligase 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PKD1L3 polycystic kidney disease 1-like 3
PM20D2 peptidase M20 domain containing 2
PNMA1 paraneoplastic Ma antigen 1
POM121 POM121 transmembrane nucleoporin
POM121L4P POM121 transmembrane nucleoporin-like 4 pseudogene
POU3F4 POU class 3 homeobox 4
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PPP1R16A protein phosphatase 1, regulatory subunit 16A
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRAM1 PML-RARA regulated adaptor molecule 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRODH2 proline dehydrogenase (oxidase) 2
PRRC1 proline-rich coiled-coil 1
PRSS45 protease, serine, 45
PTPRR protein tyrosine phosphatase, receptor type, R
PUF60 poly-U binding splicing factor 60KDa
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
RAB18 RAB18, member RAS oncogene family
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RAVER1 ribonucleoprotein, PTB-binding 1
RBM4B RNA binding motif protein 4B
RBM6 RNA binding motif protein 6
RGS18 regulator of G-protein signaling 18
RGS6 regulator of G-protein signaling 6
RHBG Rh family, B glycoprotein (gene/pseudogene)
RHOA ras homolog family member A
RHPN2 rhophilin, Rho GTPase binding protein 2
RIMS2 regulating synaptic membrane exocytosis 2
RNF213 ring finger protein 213
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RXFP3 relaxin/insulin-like family peptide receptor 3
RYR2 ryanodine receptor 2 (cardiac)
RYR3 ryanodine receptor 3
S1PR4 sphingosine-1-phosphate receptor 4
SCARF1 scavenger receptor class F, member 1
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SETD2 SET domain containing 2
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SFTPD surfactant protein D
SGSH N-sulfoglucosamine sulfohydrolase
SI sucrase-isomaltase (alpha-glucosidase)
SIK3 SIK family kinase 3
SIL1 SIL1 nucleotide exchange factor
SIN3B SIN3 transcription regulator family member B
SIPA1L3 signal-induced proliferation-associated 1 like 3
SIRT5 sirtuin 5
SLAMF1 signaling lymphocytic activation molecule family member 1
SLAMF7 SLAM family member 7
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A47 solute carrier family 25, member 47
SLC39A13 solute carrier family 39 (zinc transporter), member 13
SLC45A2 solute carrier family 45, member 2
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLITRK5 SLIT and NTRK-like family, member 5
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SOX10 SRY (sex determining region Y)-box 10
SPATA2 spermatogenesis associated 2
SPEG SPEG complex locus
SPEN spen family transcriptional repressor
SPIDR scaffolding protein involved in DNA repair
SSC5D scavenger receptor cysteine rich family, 5 domains
SVIL supervillin
SYNE1 spectrin repeat containing, nuclear envelope 1
SYNRG synergin, gamma
SZT2 seizure threshold 2 homolog (mouse)
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
TDRD5 tudor domain containing 5
TENM2 teneurin transmembrane protein 2
TEX15 testis expressed 15
TG thyroglobulin
TGM1 transglutaminase 1
THSD4 thrombospondin, type I, domain containing 4
TMEM67 transmembrane protein 67
TMUB2 transmembrane and ubiquitin-like domain containing 2
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TNXB tenascin XB
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TRPM5 transient receptor potential cation channel, subfamily M, member 5
TRRAP transformation/transcription domain-associated protein
TSC1 tuberous sclerosis 1
TSPAN11 tetraspanin 11
TTN titin
TUBB8 tubulin, beta 8 class VIII
TYRO3 TYRO3 protein tyrosine kinase
UBE2Z ubiquitin-conjugating enzyme E2Z
UNC13A unc-13 homolog A (C. elegans)
USP34 ubiquitin specific peptidase 34
USP6 ubiquitin specific peptidase 6
VARS2 valyl-tRNA synthetase 2, mitochondrial
VAV2 vav 2 guanine nucleotide exchange factor
VAX1 ventral anterior homeobox 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WBSCR17 Williams-Beuren syndrome chromosome region 17
WDR1 WD repeat domain 1
WDR49 WD repeat domain 49
WDR7 WD repeat domain 7
XIRP2 xin actin binding repeat containing 2
ZBTB17 zinc finger and BTB domain containing 17
ZC2HC1A zinc finger, C2HC-type containing 1A
ZCCHC2 zinc finger, CCHC domain containing 2
ZDHHC3 zinc finger, DHHC-type containing 3
ZFHX4 zinc finger homeobox 4
ZFP64 ZFP64 zinc finger protein
ZIK1 zinc finger protein interacting with K protein 1
ZMYM3 zinc finger, MYM-type 3
ZNF157 zinc finger protein 157
ZNF354C zinc finger protein 354C
ZNF44 zinc finger protein 44
ZNF496 zinc finger protein 496
ZNF516 zinc finger protein 516
ZNF639 zinc finger protein 639
ZNF710 zinc finger protein 710
ZNF808 zinc finger protein 808
ZNF852 zinc finger protein 852
ZNF99 zinc finger protein 99
ZSCAN20 zinc finger and SCAN domain containing 20