NCI-H596 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Human lung adenosquamous carcinoma cell line; derived in 1983 from a tumor mass in the chest wall of a patient with adenosquamous carcinoma of the lung. (BRENDA Tissue and Enzyme Source Ontology, BTO_0002209)
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160 genes mutated in the NCI-H596 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ACSL3 acyl-CoA synthetase long-chain family member 3
AKAP9 A kinase (PRKA) anchor protein 9
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ARFGEF3 ARFGEF family member 3
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ATF2 activating transcription factor 2
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BAHCC1 BAH domain and coiled-coil containing 1
BCL7B B-cell CLL/lymphoma 7B
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BTD biotinidase
C10ORF67 chromosome 10 open reading frame 67
C1ORF112 chromosome 1 open reading frame 112
C5ORF42 chromosome 5 open reading frame 42
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CAMK1 calcium/calmodulin-dependent protein kinase I
CBY3 chibby homolog 3 (Drosophila)
CCAR1 cell division cycle and apoptosis regulator 1
CCDC142 coiled-coil domain containing 142
CCDC82 coiled-coil domain containing 82
CEP290 centrosomal protein 290kDa
CEP78 centrosomal protein 78kDa
CHD1L chromodomain helicase DNA binding protein 1-like
CHPF chondroitin polymerizing factor
CLEC7A C-type lectin domain family 7, member A
COPS3 COP9 signalosome subunit 3
CPT2 carnitine palmitoyltransferase 2
CRAMP1L Crm, cramped-like (Drosophila)
CRNKL1 crooked neck pre-mRNA splicing factor 1
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2
DAB2IP DAB2 interacting protein
DNM3 dynamin 3
DSG3 desmoglein 3
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EAF2 ELL associated factor 2
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF2D eukaryotic translation initiation factor 2D
EIF5B eukaryotic translation initiation factor 5B
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB2IP erbb2 interacting protein
ERMP1 endoplasmic reticulum metallopeptidase 1
EXOC1 exocyst complex component 1
FAM171A2 family with sequence similarity 171, member A2
FAM184A family with sequence similarity 184, member A
FAM208A family with sequence similarity 208, member A
FAM212B family with sequence similarity 212, member B
FBN2 fibrillin 2
FBXL2 F-box and leucine-rich repeat protein 2
FBXO11 F-box protein 11
FERMT2 fermitin family member 2
FGFR1OP FGFR1 oncogene partner
GEMIN5 gem (nuclear organelle) associated protein 5
GMDS GDP-mannose 4,6-dehydratase
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HOXB5 homeobox B5
HOXD10 homeobox D10
IER5L immediate early response 5-like
IGSF3 immunoglobulin superfamily, member 3
INO80 INO80 complex subunit
INSR insulin receptor
JMJD1C jumonji domain containing 1C
KANK1 KN motif and ankyrin repeat domains 1
KDM8 lysine (K)-specific demethylase 8
KIAA1468 KIAA1468
KLF13 Kruppel-like factor 13
KMT2D lysine (K)-specific methyltransferase 2D
KNTC1 kinetochore associated 1
LCMT2 leucine carboxyl methyltransferase 2
LIG4 ligase IV, DNA, ATP-dependent
LIMCH1 LIM and calponin homology domains 1
LRP1 low density lipoprotein receptor-related protein 1
LRRC49 leucine rich repeat containing 49
LYST lysosomal trafficking regulator
MAPK8 mitogen-activated protein kinase 8
MEF2A myocyte enhancer factor 2A
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MKI67 marker of proliferation Ki-67
MSH2 mutS homolog 2
MUC16 mucin 16, cell surface associated
MYO5A myosin VA (heavy chain 12, myoxin)
NALCN sodium leak channel, non selective
NAV1 neuron navigator 1
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NEO1 neogenin 1
NFIL3 nuclear factor, interleukin 3 regulated
NIPAL2 NIPA-like domain containing 2
NMT2 N-myristoyltransferase 2
NPW neuropeptide W
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OSBPL9 oxysterol binding protein-like 9
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAPLN papilin, proteoglycan-like sulfated glycoprotein
PARP6 poly (ADP-ribose) polymerase family, member 6
PCDHGA6 protocadherin gamma subfamily A, 6
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRRC2A proline-rich coiled-coil 2A
PRRT3 proline-rich transmembrane protein 3
PTPMT1 protein tyrosine phosphatase, mitochondrial 1
PTPN23 protein tyrosine phosphatase, non-receptor type 23
PUF60 poly-U binding splicing factor 60KDa
PYHIN1 pyrin and HIN domain family, member 1
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RABGAP1 RAB GTPase activating protein 1
RANBP2 RAN binding protein 2
RBL1 retinoblastoma-like 1
RGS12 regulator of G-protein signaling 12
RMI1 RecQ mediated genome instability 1
RUSC2 RUN and SH3 domain containing 2
SBNO1 strawberry notch homolog 1 (Drosophila)
SCAPER S-phase cyclin A-associated protein in the ER
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2
SH3GL1 SH3-domain GRB2-like 1
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLIT3 slit homolog 3 (Drosophila)
SNCAIP synuclein, alpha interacting protein
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPG11 spastic paraplegia 11 (autosomal recessive)
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRPK3 SRSF protein kinase 3
SRSF4 serine/arginine-rich splicing factor 4
ST5 suppression of tumorigenicity 5
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
STARD9 StAR-related lipid transfer (START) domain containing 9
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TACC3 transforming, acidic coiled-coil containing protein 3
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCHH trichohyalin
TGM1 transglutaminase 1
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TMEM123 transmembrane protein 123
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRIM25 tripartite motif containing 25
TRPS1 trichorhinophalangeal syndrome I
TTC17 tetratricopeptide repeat domain 17
TUBGCP2 tubulin, gamma complex associated protein 2
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
UGDH UDP-glucose 6-dehydrogenase
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
UNKL unkempt family zinc finger-like
USP6NL USP6 N-terminal like
VCL vinculin
WDFY1 WD repeat and FYVE domain containing 1
ZBTB10 zinc finger and BTB domain containing 10
ZCCHC6 zinc finger, CCHC domain containing 6
ZNF229 zinc finger protein 229
ZNF530 zinc finger protein 530
ZNF587 zinc finger protein 587
ZNF710 zinc finger protein 710